What is Southhampton like?

Travelers to the Southhampton neighborhood in St. Louis will be sure to enjoy their stay.

How many hotels will I find in the Southhampton area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 23 Southhampton hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in Southhampton, will I receive a refund?

Yes! The majority of hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then filter by "fully refundable" to view the best deals in Southhampton.

What can I see and do in this St. Louis neighborhood?

A few places to visit in the area around Southhampton include Miniature Museum of Greater St. Louis, Lindenwood Park, and River des Peres Greenway Trailhead. When you're sightseeing in St. Louis, Tower Grove Tennis Center and George Washington Carver Garden are also worth a stop.

Hotels in Southhampton, St. Louis

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Dates

March 2026

April 2026

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Our top choices for Southhampton hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

16.6 km from Southhampton

Jaiden

CA $141 total

includes taxes & fees

Feb 23 - Feb 24

The Principal Hotel

17.9 km from Southhampton

David

CA $158 total

includes taxes & fees

Mar 23 - Mar 24

5 restaurants, breakfast, lunch, dinner served; American cuisine

River City Casino & Hotel

6.7 km from Southhampton

Theresa A

CA $165 total

includes taxes & fees

Mar 22 - Mar 23

Wingate by Wyndham St. Louis Airport

18.4 km from Southhampton

Sandra

CA $160 total

includes taxes & fees

Feb 22 - Feb 23

Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 9.3 km from Southhampton

Brad

CA $216 total

includes taxes & fees

Feb 24 - Feb 25

The Wildwood Hotel

30 km from Southhampton

Shawn

CA $137 total

includes taxes & fees

Mar 2 - Mar 3

Pear Tree Inn St. Louis Airport

18.4 km from Southhampton

Brandy

CA $145 total

includes taxes & fees

Feb 24 - Feb 25

Best Western Plus Fenton

15 km from Southhampton

Melissa

CA $144 total

includes taxes & fees

Feb 22 - Feb 23

Hampton Inn St. Louis - Columbia

17.2 km from Southhampton

Elizabeth

CA $166 total

includes taxes & fees

Mar 8 - Mar 9

Motel 6 Hazelwood, MO

22.6 km from Southhampton

Jaziel

CA $100 total

includes taxes & fees

Feb 22 - Feb 23

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Downtown St. Louis, 9.4 km from Southhampton

David

CA $160 total

includes taxes & fees

Mar 9 - Mar 10

Hyatt Select St. Louis Airport

17.5 km from Southhampton

Leon

CA $195 total

includes taxes & fees

Mar 1 - Mar 2

Best Western Plus Pontoon Beach

25.5 km from Southhampton

Todd

CA $122 total

includes taxes & fees

Feb 22 - Feb 23

Wingate by Wyndham St. Louis/Fenton Route 66

16.7 km from Southhampton

David

CA $125 total

includes taxes & fees

Feb 23 - Feb 24

Best Western St. Louis Inn

15.7 km from Southhampton

Marisa

CA $112 total

includes taxes & fees

Feb 27 - Feb 28

Hilton St. Louis Airport

17.8 km from Southhampton

Lisa

CA $197 total

includes taxes & fees

Feb 27 - Feb 28

Hampton Inn By Hilton St Louis Airport

17.8 km from Southhampton

Allyn

CA $194 total

includes taxes & fees

Feb 27 - Feb 28

Comfort Suites St Charles - St Louis

27.1 km from Southhampton

Jere

CA $124 total

includes taxes & fees

Feb 22 - Feb 23

Drury Inn & Suites St. Louis Fairview Heights

26 km from Southhampton

RANJITH

CA $145 total

includes taxes & fees

Feb 24 - Feb 25

Holiday Inn Express & Suites St. Louis West - Fenton by IHG

17 km from Southhampton

Scott

CA $144 total

includes taxes & fees

Feb 22 - Feb 23

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Where to stay in Southhampton

Find the best Southhampton areas and neighborhoods for the activities you enjoy most.

Gateway Arch featuring a monument, night scenes and a park

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

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Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

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Anheuser-Busch Brewery featuring heritage architecture and a garden

Soulard

You'll enjoy the bars and churches in Soulard. You might want to make time for a stop at Anheuser-Busch Brewery or Soulard Farmer's Market.

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Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

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