Santa María Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $1,096 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Santa María Vacation
When you book a Santa María vacation package, you can kick back and enjoy your escape to the fullest. Uncover the highlights of this fascinating city knowing that all the travel planning has been looked after before you go. San Jose Beach and Plaza de Armas are a couple of the must-see sights to visit during a trip to Santa María. No matter your travel plans or the size of your budget, putting together a tailored Santa María vacation is a breeze with Expedia.
Santa María Hotel Deals
Carnaval Hotel Casino
Av. Irrazabal, 750 Encarnacion
Fully refundableReserve now, pay when you stay
The price is CA $92 per night from Mar 22 to Mar 23
CA $92
CA $101 total
Mar 22 - Mar 23
includes taxes & fees
Sun Hotel
Encarnacion Itapúa
The price is CA $126 per night from Mar 1 to Mar 2
CA $126
CA $138 total
Mar 1 - Mar 2
includes taxes & fees
9.2/10 Wonderful! (111 reviews)
Excelent.
Reviewed on Jan 11, 2026
Hotel Luxsur
Jorge Memmel 661 Encarnacion
Fully refundableReserve now, pay when you stay
The price is CA $82 per night from Mar 31 to Apr 1
CA $82
CA $92 total
Mar 31 - Apr 1
includes taxes & fees
8.8/10 Excellent! (166 reviews)
Amazing
Reviewed on Feb 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
What to do in Santa María
The Best of Iguassu Falls, Itaipu Dam & City Tour
CA $275
per adult
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
