San Sisto Vacation Rentals from CA $106: Short-Term Rentals for 2026

Q: What's the top vacation rental that San Sisto has to offer?

Country House Le Case Coloniche : This vacation home rental near San Sisto is located in a rural location and has a terrace, a garden, and a barbecue grill to put you at ease in your new surroundings. This vacation rental also comes with free parking to give you added peace of mind.

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In two weeks

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Our top choices for San Sisto vacation rentals

A courtyard with a pool, stone benches, and a view of a hill.

1. TH Perugia - Castello di Monterone

Perugia

Sandro

CA $332 total

includes taxes & fees

Nov 5 - Nov 6

A living room with a wooden cabinet, a television, and a potted plant.

2. The little house in Perugia

Perugia

CA $159 total

includes taxes & fees

Nov 1 - Nov 2

A modern bathroom with a freestanding bathtub, a wooden robe rack, and a large mirror.

3. Welchome suites

Old Town Perugia

Andrew

CA $171 total

includes taxes & fees

Nov 1 - Nov 2

A window with a view of a cityscape, curtains partially drawn, and a balcony railing.

4. Maison Panorama

Old Town Perugia

CA $155 total

includes taxes & fees

Nov 3 - Nov 4

A balcony with a table set for two, featuring a coffee pot and two cups, surrounded by chairs.

5. House 418 Incantevole Appartamento

Perugia

Cheryl

CA $148 total

includes taxes & fees

Nov 15 - Nov 16

A yellow outdoor table with a chair, a potted plant, and a cup of coffee on a balcony with a view of a cityscape.

6. Tentazioni Raffinate - Luxury Suite

Perugia

CA $270 total

includes taxes & fees

Nov 26 - Nov 27

A hotel room with a bed, a bedside table with a candle, and a wall-mounted picture.

7. Il Casale Ritrovato

Perugia

CA $139 total

includes taxes & fees

Nov 2 - Nov 3

A modern hotel room with a bed, a bedside table with a lamp, a TV, and a view of the kitchen.

8. Cozy attic room near the Perugia train station

Perugia

Stefania

CA $150 total

includes taxes & fees

Nov 8 - Nov 9

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Top San Sisto Hotel Reviews

Il Palazzo

10/10 Excellent

"After a grueling walk up from the central bus stop we arrived at the hotel (take a taxi from the train station, you’ll thank me!) Getting around the hotel was a bit like Theseus going through the labyrinth but luckily no Minotaur at the end, instead a quiet and comfortable room. The breakfast was quite good with plentiful choices. Location was excellent, an easy walk to visit both St. Francis and St. Claire. We’ll be back!"

Chocohotel

8/10 Good

"It's a large hotel, with nice but standard rooms, full bath. It's fully committed to its chocolate theme, which makes it a little kitschy, but has an amazingly large breakfast with both sweet and savory items. It's located outside the center, so a bit of walk uphill to the center, or you could take public transport (bus or Mini-metro). The hotel has free, easy and ample parking, so it could be a great base for exploring nearby towns."

TH Assisi - Hotel Cenacolo

10/10 Excellent

"This location is just between The Basilica of Santa Maria degli Angeli and Basilica of San Francesco d'Assisi along a brick walkway between the two. “De Angeli” is a 15 minute walk flat and San Francesco is a 45 monitor walk all up hill. The hotel offers breakfast which you can book along with your reservation that is bountiful and includes eggs to order. Dinner is available with a reservation which can made the same day. We left the hotel early to drive to Roma and they had a box breakfast waiting for to take along on our drive. We stayed in a standard double bed room which was small but included a refrigerator, a bottle of water, a teapot, assorted teas, and shower gel, shampoo, and hand soap. The bed was European king with allergy pillows, but a hard mattress compared to American standards. The staff is very attentive, on duty 24/7, and accommodating. The parking lot is plentiful and free. There is a bus stop right outside the hotel that will take you very near Basilica of San Francesco d'Assisi, and the Rocca Maggiore. If you end up at San Damiano, there is a bus that will take you back to San Francesco d’Assisi and The Eremo delle Carceri."

Find out more about San Sisto

Everything you need to know about San Sisto vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the San Sisto vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect San Sisto vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

San Sisto vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in San Sisto. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A San Sisto vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of San Sisto vacation rentals we have selected for you start as low as CA $106 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on San Sisto rentals

At Expedia, we put the best San Sisto vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top San Sisto rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream San Sisto vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around San Sisto. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in San Sisto?

Yes, we give you a choice of vacation rentals in San Sisto close to Perugina Chocolate Factory, or you can select a secluded option if you're looking for extra privacy while you relax.

What's the top vacation rental that San Sisto has to offer?

Country House Le Case Coloniche: This vacation home rental near San Sisto is located in a rural location and has a terrace, a garden, and a barbecue grill to put you at ease in your new surroundings. This vacation rental also comes with free parking to give you added peace of mind.

How many vacation rentals will I find in San Sisto?

With 3 Expedia vacation rentals, you're sure to find just the right place for your San Sisto stay.

What’s there to see and do in San Sisto?

Explore the area and family-friendly sights such as Perugina Chocolate Factory, or get out into nature at a spot like Lake Trasimeno. Renato Curi Stadium and Citta della Domenica are a couple of places you'll find in the larger area.

What’s a vacation rental in San Sisto like?

Vacation rentals are private properties where you can stay for short or long periods in San Sisto. Vacation rentals provide amenities such as patios, hot tubs, and fire pits so you'll have everything you want. If you're concerned about cleanliness, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great option for a family getaway.

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Check prices for these dates

Our top choices for San Sisto vacation rentals

1. TH Perugia - Castello di Monterone

2. The little house in Perugia

3. Welchome suites

4. Maison Panorama

5. House 418 Incantevole Appartamento

6. Tentazioni Raffinate - Luxury Suite

7. Il Casale Ritrovato

8. Cozy attic room near the Perugia train station

9. Station 27

10. Country House Le Case Coloniche

11. Appartamento Perugia 705/B

12. Cozy City Apartment "A Casa di Adriana" — Your Home Away from Home!

13. L'Antica Sosta

14. Casa Miramonti in Perugia

15. Traditional Two-Room Apartment 15 Minutes from the Center of Perugia

16. Luxury Suite - Tentazioni Nascoste

17. Italian Experience-Casa Miramonti

18. Stunning villa for 6 guests with A/C, WIFI, TV, balcony and panoramic view

19. Colle di Perugia - cozy apartment in villa

20. I Casali della Ghisleria

Find vacation rentals that suit your style

Top San Sisto Hotel Reviews

Il Palazzo

Chocohotel

Giotto Hotel & Spa

Hotel Sorella Luna

Hotel Priori Secret Garden

Hotel Sant'Ercolano

BV Grand Hotel Assisi

TH Assisi - Hotel Cenacolo

Hotel Giò Wine e Jazz Area

Find out more about San Sisto

Frequently asked questions

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