A calm sea with a small boat and a row of palm trees on the shore.

Eastern Panama Vacation Rentals

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Our top choices for Eastern Panama vacation rentals

1. san blas luxury tour

san blas luxury tour
2.0 star property
Nusatupo
The price is CA $151
CA $171 total
includes taxes & fees
Oct 30 - Oct 31
san blas luxury tour

2. glampling sanblas luxury

glampling sanblas luxury
1.0 star property
Nargana
The price is CA $479
CA $527 total
includes taxes & fees
Oct 30 - Oct 31
glampling sanblas luxury

3. Beach Cabin on the San Blas Islands: Aroma

Beach Cabin on the San Blas Islands: Aroma
Guna Yala
The price is CA $95
CA $229 total
includes taxes & fees
Oct 27 - Oct 28
Beach Cabin on the San Blas Islands: Aroma

4. San Blas Private Oceanfront Cabin

San Blas Private Oceanfront Cabin
2.5 star property
Narganá
The price is CA $363
CA $539 total
includes taxes & fees
Oct 28 - Oct 29
San Blas Private Oceanfront Cabin

5. San Blas Tour Aridub

San Blas Tour Aridub
2.0 star property
Narganá
The price is CA $108
CA $335 total
includes taxes & fees
Nov 10 - Nov 11
San Blas Tour Aridub

6. Pelicano Island

Pelicano Island
2.0 star property
Moraquedub
The price is CA $454
CA $499 total
includes taxes & fees
Oct 27 - Oct 28
Pelicano Island

7. San Blas Private Beach Cabin

San Blas Private Beach Cabin
2.5 star property
Narganá
The price is CA $326
CA $359 total
includes taxes & fees
Nov 7 - Nov 8
San Blas Private Beach Cabin

8. Sanblastourgy

Sanblastourgy
2.0 star property
Nargana
The price is CA $284
CA $313 total
includes taxes & fees
Oct 27 - Oct 28
Sanblastourgy

9. Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island
2.5 star property
Narganá
The price is CA $293
CA $462 total
includes taxes & fees
Oct 27 - Oct 28
Private Over-Water Cabins on San Blas Island

10. Private Over-the-Water Cabin in San Blas including Meals

Private Over-the-Water Cabin in San Blas including Meals
2.5 star property
Mirladub
The price is CA $618
CA $749 total
includes taxes & fees
Oct 29 - Oct 30
Private Over-the-Water Cabin in San Blas including Meals

11. Casa frente al mar - turtle cay marina

Casa frente al mar - turtle cay marina
2.5 star property
Nombre de Dios
The price is CA $749
CA $879 total
includes taxes & fees
Nov 15 - Nov 16
Casa frente al mar - turtle cay marina

12. All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama
Guna Yala Comarca
The price is CA $1,059
CA $1,239 total
includes taxes & fees
Nov 2 - Nov 3
All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

13. San Blas Private Over-the-Water Cabin

San Blas Private Over-the-Water Cabin
2.5 star property
Narganá
8.0 out of 10, Very good, (2 reviews)
"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...
United States
Andrew
The price is CA $332
CA $505 total
includes taxes & fees
Oct 28 - Oct 29
San Blas Private Over-the-Water Cabin

14. Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand
Palenque
9.0 out of 10, Wonderful, (4 reviews)
"the view is beautiful! We were taken care of well."
United States
Mirelys
The price is CA $339
CA $444 total
includes taxes & fees
Oct 27 - Oct 28
Caribbean getaway: beach cottage just on the sand

15. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
Puerto Lindo
The price is CA $315
CA $357 total
includes taxes & fees
Oct 27 - Oct 28
Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

16. Tiny Cabin

Tiny Cabin
3.0 star property
Panamá
10.0 out of 10, Exceptional, (1 review)
The price is CA $187
CA $206 total
includes taxes & fees
Nov 12 - Nov 13
Tiny Cabin

17. Elegance and Comfort in Panama City's Old Town

Elegance and Comfort in Panama City's Old Town
Panamá
2.0 out of 10, (1 review)
"The address that’s depicted is not accurate to the map that’s shown and I tried multiple times to communicate with the host and no response"
United States
PAMELA
The price is CA $70
CA $126 total
includes taxes & fees
Oct 27 - Oct 28
Elegance and Comfort in Panama City's Old Town

18. Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita
Maria Chiquita
6.6 out of 10, (4 reviews)
"Well-appointed apartment, view of the ocean, big pool, fast Internet, attentive security. We had a great time here, thanks!"
United States
Will
The price is CA $150
CA $228 total
includes taxes & fees
Oct 27 - Oct 28
Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

19. Cozy Cabin in the Misty Mountain

Cozy Cabin in the Misty Mountain
Panamá
The price is CA $112
CA $161 total
includes taxes & fees
Oct 27 - Oct 28
Cozy Cabin in the Misty Mountain

20. A cozy and safe neighborhood near the airport

A cozy and safe neighborhood near the airport
Panamá
The price is CA $87
CA $115 total
includes taxes & fees
Oct 27 - Oct 28
A cozy and safe neighborhood near the airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Eastern Panama Hotel Reviews

Find out more about Eastern Panama

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Eastern Panama. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.