Eastern Panama Vacation Rentals from CA $173: Short-Term Rentals for 2026

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Our top choices for Eastern Panama vacation rentals

A tropical beach with clear turquoise waters, palm trees, and a small island with buildings.

1. san blas luxury tour

Nusatupo

CA $173 total

includes taxes & fees

Oct 10 - Oct 11

A tent with a view of a beach and palm trees, a red umbrella, and a wooden deck.

2. glampling sanblas luxury

Nargana

CA $535 total

includes taxes & fees

Oct 10 - Oct 11

A tropical beach with palm trees and clear turquoise waters.

3. San Blas Private Oceanfront Cabin

Narganá

CA $547 total

includes taxes & fees

Oct 10 - Oct 11

A coconut on a wooden table under a wooden structure by the beach with palm trees and the ocean in the background.

4. Sanblastourgy

Nargana

CA $317 total

includes taxes & fees

Oct 10 - Oct 11

A beach with clear turquoise water, a wooden structure with a red roof, and a white sandy shore.

5. Pelicano Island

Moraquedub

CA $507 total

includes taxes & fees

Oct 10 - Oct 11

6. San Blas Private Over-the-Water Cabin

Narganá

"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...

Andrew

CA $513 total

includes taxes & fees

Oct 11 - Oct 12

A beach with clear water and a distant island.

7. San Blas Tour Aridub

Narganá

CA $340 total

includes taxes & fees

Oct 25 - Oct 26

A beach with palm trees, a thatched-roof hut, and a sandy shore.

8. Beachfront Cabin on the San Blas Islands: Aroma

Guna Yala

CA $231 total

includes taxes & fees

Oct 12 - Oct 13

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Top Eastern Panama Hotel Reviews

Caribbean Haven Of Nature 'Preci Beach'

10/10 Excellent

"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote and while getting there is a bit of a challenge, once there, the serene and peaceful setting allows you to really unwind. At no time, was safety a concern for any of us. If you are looking for a pristine, sterile location this may not be for you, but if you want to feel welcomed into someone’s beach house in a magnificent setting, this place is excellent."

Ranchos de Chalia

8/10 Good

"The hotel is a sleepy bed breakfast located close to the coast next to a tiny village. The property is older it could do a facelift. The single rooms are small, but functional. The air condition worked great. The pool was a big plus .The staff was very helpful and accommodating. My biggest concern was lack of communication when we tried via Expedia to get more information about directions and check-in. However, it worked ok in the end."

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent

"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "

Find out more about Eastern Panama

Everything you need to know about Eastern Panama vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Eastern Panama vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Eastern Panama vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Eastern Panama vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Eastern Panama. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Eastern Panama vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Eastern Panama vacation rentals we have selected for you start as low as CA $173 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Eastern Panama rentals

At Expedia, we put the best Eastern Panama vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Eastern Panama rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Eastern Panama vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Eastern Panama. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Check prices for these dates

Our top choices for Eastern Panama vacation rentals

1. san blas luxury tour

2. glampling sanblas luxury

3. San Blas Private Oceanfront Cabin

4. Sanblastourgy

5. Pelicano Island

6. San Blas Private Over-the-Water Cabin

7. San Blas Tour Aridub

8. Beachfront Cabin on the San Blas Islands: Aroma

9. Private Over-Water Cabins on San Blas Island

10. Private Over-the-Water Cabin in San Blas including Meals

11. All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

12. San Blas Private Beach Cabin

13. Caribbean getaway: beach cottage just on the sand

14. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

15. Tiny Cabin

16. Elegance and comfort in old town panama

17. Cozy Cabin in the Misty Mountain

18. Cozy and Safe Environment Close to the Airport.

19. Your country home, Menus de la Montaña, awaits you

20. Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

Find vacation rentals that suit your style

Top Eastern Panama Hotel Reviews

Caribbean Haven Of Nature 'Preci Beach'

Ranchos de Chalia

Ciel y Miel

Caribbean getaway: beach cottage just on the sand

Ordovician Beach Resort

Private Ocean-Front Cabin with private bathroom on San Blas Island

Konsenda San Blas

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

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