A calm sea with a small boat and a row of palm trees on the shore.

Eastern Panama Vacation Rentals

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Our top choices for Eastern Panama vacation rentals

1. san blas luxury tour

san blas luxury tour
2.0 star property
Nusatupo
The price is CA $172
CA $194 total
includes taxes & fees
Sep 22 - Sep 23
san blas luxury tour

2. Beachfront Cabin on the San Blas Islands: Aroma

Beachfront Cabin on the San Blas Islands: Aroma
Guna Yala
The price is CA $94
CA $227 total
includes taxes & fees
Sep 21 - Sep 22
Beachfront Cabin on the San Blas Islands: Aroma

3. Pelicano Island

Pelicano Island
2.0 star property
Moraquedub
The price is CA $453
CA $499 total
includes taxes & fees
Oct 18 - Oct 19
Pelicano Island

4. San Blas Private Oceanfront Cabin

San Blas Private Oceanfront Cabin
2.5 star property
Narganá
The price is CA $362
CA $538 total
includes taxes & fees
Oct 18 - Oct 19
San Blas Private Oceanfront Cabin

5. Sanblastourgy

Sanblastourgy
2.0 star property
Nargana
The price is CA $284
CA $312 total
includes taxes & fees
Oct 18 - Oct 19
Sanblastourgy

6. San Blas Private Beach Cabin

San Blas Private Beach Cabin
2.5 star property
Narganá
The price is CA $375
CA $413 total
includes taxes & fees
Sep 20 - Sep 21
San Blas Private Beach Cabin

7. Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island
2.5 star property
Narganá
The price is CA $292
CA $462 total
includes taxes & fees
Oct 18 - Oct 19
Private Over-Water Cabins on San Blas Island

8. San Blas Tour Aridub

San Blas Tour Aridub
2.0 star property
Narganá
The price is CA $120
CA $348 total
includes taxes & fees
Oct 18 - Oct 19
San Blas Tour Aridub

9. Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand
Palenque
9.0 out of 10, Wonderful, (4 reviews)
"the view is beautiful! We were taken care of well."
United States
Mirelys
The price is CA $339
CA $441 total
includes taxes & fees
Sep 21 - Sep 22
Caribbean getaway: beach cottage just on the sand

10. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
Puerto Lindo
The price is CA $315
CA $357 total
includes taxes & fees
Sep 19 - Sep 20
Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

11. All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama
Guna Yala Comarca
The price is CA $1,046
CA $1,243 total
includes taxes & fees
Oct 2 - Oct 3
All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

12. Private Over-the-Water Cabin in San Blas including Meals

Private Over-the-Water Cabin in San Blas including Meals
2.5 star property
Mirladub
The price is CA $617
CA $749 total
includes taxes & fees
Sep 21 - Sep 22
Private Over-the-Water Cabin in San Blas including Meals

13. Deluxe Beachfront 4-bedroom house in Colón Province

Deluxe Beachfront 4-bedroom house in Colón Province
Colón Province
The price is CA $474
CA $540 total
includes taxes & fees
Sep 19 - Sep 20
Deluxe Beachfront 4-bedroom house in Colón Province

14. San Blas Private Over-the-Water Cabin

San Blas Private Over-the-Water Cabin
2.5 star property
Narganá
8.0 out of 10, Very good, (2 reviews)
"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...
United States
Andrew
The price is CA $351
CA $526 total
includes taxes & fees
Sep 19 - Sep 20
San Blas Private Over-the-Water Cabin

15. Tiny Cabin

Tiny Cabin
3.0 star property
Panamá
10.0 out of 10, Exceptional, (1 review)
The price is CA $187
CA $206 total
includes taxes & fees
Sep 21 - Sep 22
Tiny Cabin

16. Cozy Cabin in the Misty Mountain

Cozy Cabin in the Misty Mountain
Panamá
The price is CA $112
CA $161 total
includes taxes & fees
Sep 19 - Sep 20
Cozy Cabin in the Misty Mountain

17. Elegance and comfort in old town panama

Elegance and comfort in old town panama
Panamá
2.0 out of 10, (1 review)
"The address that’s depicted is not accurate to the map that’s shown and I tried multiple times to communicate with the host and no response"
United States
PAMELA
The price is CA $70
CA $105 total
includes taxes & fees
Sep 19 - Sep 20
Elegance and comfort in old town panama

18. La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama
Panamá
The price is CA $252
CA $399 total
includes taxes & fees
Sep 19 - Sep 20
La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

19. Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway
Panamá
The price is CA $168
CA $196 total
includes taxes & fees
Sep 19 - Sep 20
Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

20. Cozy and Safe Environment Close to the Airport.

Cozy and Safe Environment Close to the Airport.
Panamá
The price is CA $87
CA $115 total
includes taxes & fees
Sep 21 - Sep 22
Cozy and Safe Environment Close to the Airport.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Eastern Panama Hotel Reviews

Find out more about Eastern Panama

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Eastern Panama. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.