Default HTG hotel image

Mill Creek Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 13 - Nov 15
In two months
Dec 25 - Dec 27
In three months
Jan 22 - Jan 24
In four months
Feb 19 - Feb 21

Our top choices for Mill Creek vacation rentals

A log cabin with a metal roof, two windows, a door, and a porch with two rocking chairs and a small table.

1. Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (431 reviews)
"Beautiful quaint cabin! Had everything you could need. Would definitely recommend to anyone looking for a nice place to stay."
United States
Brandon
The price is CA $164
CA $291 total
includes taxes & fees
Oct 29 - Oct 30
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
A living room with a TV, a fireplace, a sofa, and wall art.

2. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $114
CA $152 total
includes taxes & fees
Oct 29 - Oct 30
Little Blue Cottage on Spanish
A room with a clear glass display unit holding wine bottles and glasses.

3. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (29 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is CA $150
CA $250 total
includes taxes & fees
Oct 29 - Oct 30
Cozy and Updated Farmhouse with King Suite
A small, single-story building with a wooden exterior and large windows.

4. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is CA $158
CA $197 total
includes taxes & fees
Oct 29 - Oct 30
The Rested Duck Mallard Room
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

5. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
The price is CA $158
CA $197 total
includes taxes & fees
Nov 7 - Nov 8
Cozy cabins on beautiful Horseshoe Lake
A modern kitchen with wooden cabinets, a central island with bar stools, a built-in oven, and a television mounted on the wall.

6. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (15 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
United States
Dylan
The price is CA $193
CA $403 total
includes taxes & fees
Nov 10 - Nov 11
Stunning 2 bedroom in town, close to Shawnee National Forest
A serene outdoor area with a pond, surrounded by trees and a grassy lawn. There are two wooden benches facing the water.

7. Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (107 reviews)
"The cottage was clean, spacious, had 2 bathrooms (which is uncommon for small cabins). It was very well stocked with kitchen items, and the bath towels were awesome, the bed was very nice. It was peaceful and beautiful. The hostess, Suzie was easy to contact and helpful when we had a question upon checking ìn. I would recommend this place and would stay again if we are in the area!"
United States
Teresa
The price is CA $221
CA $396 total
includes taxes & fees
Nov 6 - Nov 7
Charming cottage overlooking Lake Acre
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

8. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (39 reviews)
"Great place in a beautiful location. "
United States
George B.
The price is CA $177
CA $278 total
includes taxes & fees
Oct 29 - Oct 30
Peaceful secluded cabin located near Horseshoe Lake
A cozy cabin interior with a wooden interior, a dining area with a table and chairs, a kitchen with a refrigerator and microwave, and a window with a view of greenery.

9. Shawnee Wine Trail Farm Stay

Shawnee Wine Trail Farm Stay
Makanda
10.0 out of 10, Exceptional, (24 reviews)
"We enjoyed our stay! It was peaceful and tranquil and everything we needed was provided. The farm animals are a fun bonus and the guard dogs were so friendly"
United States
Abigail J.
The price is CA $66
CA $173 total
includes taxes & fees
Oct 29 - Oct 30
Shawnee Wine Trail Farm Stay
An aerial view of a river surrounded by dense forest, with a small house near the water's edge.

10. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (4 reviews)
"nice property would stay there again"
United States
Brian F.
The price is CA $252
CA $374 total
includes taxes & fees
Oct 29 - Oct 30
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
A spacious living area with a kitchen, a dining table, and comfortable seating.

11. Peach Tree Inn, downtown Cobden

Peach Tree Inn, downtown Cobden
Cobden
10.0 out of 10, Exceptional, (3 reviews)
"Amazing place to stay. Excellent location, beautiful rooms and accommodation and the host was so responsive. We will definitely be back!"
United States
Rebecca L.
The price is CA $266
CA $324 total
includes taxes & fees
Oct 29 - Oct 30
Peach Tree Inn, downtown Cobden
A spacious living room with a brown leather sofa, a dining area with a wooden table and chairs, a kitchen with white cabinets and a central island, and large windows with blinds.

12. Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
Anna
10.0 out of 10, Exceptional, (14 reviews)
"We enjoyed our stay here. The beds were very comfortable and it was close to all of the wineries along the wine trail."
United States
Kristi H.
The price is CA $177
CA $385 total
includes taxes & fees
Oct 29 - Oct 30
Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

13. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is CA $218
CA $316 total
includes taxes & fees
Oct 30 - Oct 31
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
A cabin with a porch, surrounded by trees.

14. Maple Ridge Cabin at Panther's Rest

Maple Ridge Cabin at Panther's Rest
Makanda
9.6 out of 10, Exceptional, (34 reviews)
"Great place to be away from the rush of things. "
United States
Lisa D.
The price is CA $122
CA $234 total
includes taxes & fees
Oct 29 - Oct 30
Maple Ridge Cabin at Panther's Rest
Exterior

15. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
The price is CA $193
CA $284 total
includes taxes & fees
Nov 1 - Nov 2
Purple Tiny House with Fire pit & Nature
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

16. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is CA $218
CA $310 total
includes taxes & fees
Oct 29 - Oct 30
The Little Château | Woodland Escape
A row of colorful houses with a clear sky and trees in the background.

17. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
The price is CA $234
CA $334 total
includes taxes & fees
Nov 2 - Nov 3
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
A two-story house with a front porch, a small garden, and a white picket fence.

18. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $251
CA $445 total
includes taxes & fees
Nov 2 - Nov 3
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
A wooden cabin with a porch, a door with a wreath, and potted plants.

19. Contemporary Glamping with Native American Appeal

Contemporary Glamping with Native American Appeal
Anna
9.8 out of 10, Exceptional, (160 reviews)
"Everything was just as advertised. Perfect stay. "
United States
Jonathan P.
The price is CA $236
CA $450 total
includes taxes & fees
Oct 29 - Oct 30
Contemporary Glamping with Native American Appeal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mill Creek Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"I would like to see hand lotion in the room or bathroom. It always used to be in the rooms of most every hotel, and now for some reason we can't have it. The breakfast was great, the hotel was very nice and the room was great. There was a hot tub and pool."
Marilyn 1-night trip
Posted less than an hour ago
Drury Plaza Hotel Cape Girardeau Conference Center

Find out more about Mill Creek

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Mill Creek. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find a vacation rental in Mill Creek?

Yes, there are vacation rentals near the most popular local attractions in Mill Creek, or you can select a more remote option if you want a relaxing place to stay.

What's the top vacation rental that Mill Creek has to offer?

* On the Wine Trail * Hot Tub * Wi-Fi *: This vacation home rental near Mill Creek is located on a lake and has a patio, a hot tub, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave.

What can I see and do in Mill Creek?

While exploring the area, visit family-friendly sights like Henry N Barkhausen Cache River Wetlands Center, or get outside and enjoy nature at Lower Cache River Access Area. In the larger area, you’ll find Trail of Tears State Park and Century Casino & Hotel Cape Girardeau.

What are vacation rentals like in Mill Creek?

Vacation rentals are private accommodations you can stay in for a few days or a quick weekend in Mill Creek. Vacation rentals offer amenities such as kitchens and laundry facilities so you'll have everything you need. If you're concerned about cleanliness, a vacation rental can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for small groups.