Photo by Lane

Mesilla Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Aug 22 - Aug 24
In two weeks
Aug 29 - Aug 31
In one month
Sep 12 - Sep 14
In two months
Oct 10 - Oct 12

Browse Select Mesilla Vacation Homes

Quaint Southwest Mesilla Home - Pet Friendly
Outdoor dining

Quaint Southwest Mesilla Home - Pet Friendly

9.6 out of 10, Exceptional, (35)
"Nice dog friendly home"
The price is CA $99
CA $264 total
includes taxes & fees
Aug 17 - Aug 18
Quaint Southwest Mesilla Home - Pet Friendly
Cozy pet friendly house with a great outdoor space, and fully stocked kitchen.
Fridge, microwave, oven, stovetop

Cozy pet friendly house with a great outdoor space, and fully stocked kitchen.

10.0 out of 10, Exceptional, (26)
"Jacuzzi was great"
Cozy pet friendly house with a great outdoor space, and fully stocked kitchen.
Unique 1-bedroom casita in Mesilla Park with hot tub
Smart TV, fireplace

Unique 1-bedroom casita in Mesilla Park with hot tub

10.0 out of 10, Exceptional, (17)
"We had a wonderful time in the area and the house was great and close to everything "
The price is CA $105
CA $204 total
includes taxes & fees
Aug 13 - Aug 14
Unique 1-bedroom casita in Mesilla Park with hot tub
Casa de Flores 3 bdrm, 2 bath with covered hot tub
Outdoor spa tub

Casa de Flores 3 bdrm, 2 bath with covered hot tub

10.0 out of 10, Exceptional, (90)
"Lovely home - spacious, well-equipped kitchen, very clean. Host clearly communicated check-in information. Easy access to NMSU and the pool. The brownies and chips & salsa were wonderful!"
Casa de Flores 3 bdrm, 2 bath with covered hot tub
Casita Azul, Mesilla Plaza Only Steps Away
Outdoor dining

Casita Azul, Mesilla Plaza Only Steps Away

10.0 out of 10, Exceptional, (169)
"Perfect place to stay during your visit to Mesilla/Las Cruces. "
Casita Azul, Mesilla Plaza Only Steps Away
Cheerful desert oasis home with a privacy hot tub! 1 minute to new hospital!
Fridge, microwave, oven, stovetop

Cheerful desert oasis home with a privacy hot tub! 1 minute to new hospital!

10.0 out of 10, Exceptional, (34)
"Very nice clean we were not there long just evening left next morning but we had dinner out on back patio. Very nice and peaceful "
The price is CA $136
CA $274 total
includes taxes & fees
Aug 27 - Aug 28
Cheerful desert oasis home with a privacy hot tub! 1 minute to new hospital!
Serene Spa hot tub Sanctuary with patio for the whole family
Terrace/patio

Serene Spa hot tub Sanctuary with patio for the whole family

9.6 out of 10, Exceptional, (29)
"Great location and very roomy."
The price is CA $136
CA $267 total
includes taxes & fees
Aug 13 - Aug 14
Serene Spa hot tub Sanctuary with patio for the whole family
Elvis’s Cozy Casa- Charming 3 bedroom,2 bathroom home w/ Mountain views
Property grounds

Elvis’s Cozy Casa- Charming 3 bedroom,2 bathroom home w/ Mountain views

10.0 out of 10, Exceptional, (11)
"The home is in a good area. Had excellent communication with the host. The home is gorgeous and we loved all the amenities and details. So happy we stayed here."
The price is CA $179
CA $285 total
includes taxes & fees
Aug 13 - Aug 14
Elvis’s Cozy Casa- Charming 3 bedroom,2 bathroom home w/ Mountain views
Desert Pool Oasis located in the heart of Las Cruces
Interior

Desert Pool Oasis located in the heart of Las Cruces

9.8 out of 10, Exceptional, (119)
"It’s a great location to everything. Quiet neighborhood, everything you need is there . Pool was nice. House was clean , well organized."
Desert Pool Oasis located in the heart of Las Cruces
Casa Elena Adobe casita in historic Mesilla
Interior

Casa Elena Adobe casita in historic Mesilla

9.0 out of 10, Wonderful, (18)
"Property was very nice, well equipped, great communication, and location was ideal for dining and shopping. "
Casa Elena Adobe casita in historic Mesilla
The Francisco and Maria Amador house is in the heart of downtown Las Cruces.
Interior

The Francisco and Maria Amador house is in the heart of downtown Las Cruces.

9.6 out of 10, Exceptional, (11)
"Very nice people and clean! "
The Francisco and Maria Amador house is in the heart of downtown Las Cruces.
NEW!!!!! Beautifully Remodeled 5 Bedroom Mesilla Street Home- All New Furniture
Fridge, microwave, oven, stovetop

NEW!!!!! Beautifully Remodeled 5 Bedroom Mesilla Street Home- All New Furniture

10.0 out of 10, Exceptional, (9)
"We enjoy this house! Clean, well decorated, plenty of room for all of us."
NEW!!!!! Beautifully Remodeled 5 Bedroom Mesilla Street Home- All New Furniture
"Casa de Maíz" centrally located - close to NMSU
Interior

"Casa de Maíz" centrally located - close to NMSU

10.0 out of 10, Exceptional, (39)
"Very nice homey place to stay, owners go above and beyond to make you feel welcome. I will be staying here again."
"Casa de Maíz" centrally located - close to NMSU
⭐️ Western Style Casita with 3BR and a Fitness Room and BBQ grill
Smart TV, books

⭐️ Western Style Casita with 3BR and a Fitness Room and BBQ grill

10.0 out of 10, Exceptional, (22)
"Very clean and hospitable. Very comfortable furniture for a relaxing time. "
⭐️ Western Style Casita with 3BR and a Fitness Room and BBQ grill
Modern High Desert 3BR Retreat
Fridge, microwave, oven, stovetop

Modern High Desert 3BR Retreat

The price is CA $123
CA $418 total
includes taxes & fees
Aug 13 - Aug 14
Modern High Desert 3BR Retreat
Modern Farmhouse Near Bike Path with Spectacular Views!
Property grounds

Modern Farmhouse Near Bike Path with Spectacular Views!

10.0 out of 10, Exceptional, (20)
"Great place to stay! Comfortable and well stocked. "
Modern Farmhouse Near Bike Path with Spectacular Views!
5 Acre Horse Ranch next to University.
Exterior

5 Acre Horse Ranch next to University.

9.6 out of 10, Exceptional, (15)
"Very beautiful property with privacy and safety. Lots of space for a family. Walkable with gorgeous views. Great for dog too. "
5 Acre Horse Ranch next to University.
Lovely 3-bedroom 3baths house in Las Cruces with AC, WiFi. Enjoy!
Fridge, microwave, oven, stovetop

Lovely 3-bedroom 3baths house in Las Cruces with AC, WiFi. Enjoy!

10.0 out of 10, Exceptional, (6)
"This house is fantastic and the owners are super helpful. Would 100% stay here again"
Lovely 3-bedroom 3baths house in Las Cruces with AC, WiFi. Enjoy!
Desert Whisper 3-bedroom home with WiFi, AC, EV charger
Fridge, microwave, oven, stovetop

Desert Whisper 3-bedroom home with WiFi, AC, EV charger

9.8 out of 10, Exceptional, (7)
"Ver nice, clean property"
Desert Whisper 3-bedroom home with WiFi, AC, EV charger
Hacienda de Horacio a 3 bedroom w/2 king beds, private patio and parking.
Property grounds

Hacienda de Horacio a 3 bedroom w/2 king beds, private patio and parking.

10.0 out of 10, Exceptional, (2)
"Fabulous house in the heart of everything. Super clean and adorable. Highly recommend. "
Hacienda de Horacio a 3 bedroom w/2 king beds, private patio and parking.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mesilla Hotel Reviews

Casita Azul, Mesilla Plaza Only Steps Away

Casita Azul, Mesilla Plaza Only Steps Away

10/10 Excellent
"So peaceful and quiet. Only the comforting church bells and birds were heard! Clean, comfortable accomodations. "
Zoe D. 2-night trip
Posted 21 hours ago
Casita Azul, Mesilla Plaza Only Steps Away