A bridge over a muddy river with green trees and hills in the background.

Mississippi County Vacation Rentals

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Our top choices for Mississippi County vacation rentals

A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

1. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is CA $211
CA $411 total
includes taxes & fees
Sep 29 - Sep 30
Quiet Country Stay: Modern Home Near Paducah
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

2. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (37 reviews)
"Great place in a beautiful location. "
United States
George B.
The price is CA $198
CA $307 total
includes taxes & fees
Oct 1 - Oct 2
Peaceful secluded cabin located near Horseshoe Lake
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

3. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
10.0 out of 10, Exceptional, (4 reviews)
"Host was great. "
United States
Sheila C.
The price is CA $154
CA $418 total
includes taxes & fees
Sep 29 - Sep 30
Quiet Country Stay: Modern Home Near Paducah
A hot tub in an outdoor setting with a wooden deck and lounge chairs.

4. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
The price is CA $174
CA $264 total
includes taxes & fees
Sep 29 - Sep 30
Perfect Couples Retreat - firepit
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

5. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (43 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
The price is CA $159
CA $199 total
includes taxes & fees
Oct 4 - Oct 5
Cozy cabins on beautiful Horseshoe Lake
A covered outdoor seating area with stone flooring and chairs, a stone pathway, and a wooden structure.

6. Vacation rental attached to our house out in the country.

Vacation rental attached to our house out in the country.
Union City
10.0 out of 10, Exceptional, (7 reviews)
"The home was spotless, very comfortable and a great location for what we needed."
United States
Sherrie S.
The price is CA $141
CA $229 total
includes taxes & fees
Sep 29 - Sep 30
Vacation rental attached to our house out in the country.
A small, single-story building with a wooden exterior and large windows.

7. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is CA $159
CA $199 total
includes taxes & fees
Oct 5 - Oct 6
The Rested Duck Mallard Room
A modern kitchen with a built-in microwave, stainless steel appliances, and a sink.

8. Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
10.0 out of 10, Exceptional, (25 reviews)
"Location was great. Beds were so comfortable, place was so clean and nice. Very cute place to stay. Would stay here again!"
United States
Deannena H.
The price is CA $156
CA $292 total
includes taxes & fees
Sep 29 - Sep 30
Charming Home just minutes from Interstate and Mall
A wooden interior with a herringbone floor, a sliding barn door, a wooden door with a glass panel, and a window with blinds.

9. Tiny house on the lake with tv free internet walk shower

Tiny house on the lake with tv free internet walk shower
Tiptonville
10.0 out of 10, Exceptional, (1 review)
"Dave was very accommodating and the home was clean."
United States
Katherine P.
The price is CA $191
CA $352 total
includes taxes & fees
Sep 29 - Sep 30
Tiny house on the lake with tv free internet walk shower
A kitchen with wooden cabinets, a stainless steel stove, and a wall-mounted sign.

10. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
The price is CA $202
CA $294 total
includes taxes & fees
Oct 3 - Oct 4
The Roost | Hot Tub, Ponds & Farm Views
A room with a pool table, a sofa, and a dining table with chairs.

11. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (3 reviews)
"The location is lovely and peaceful. The cabin is clean, comfortable and relaxing. We enjoyed the pool table and ping pong."
United States
Michelle U.
The price is CA $255
CA $375 total
includes taxes & fees
Sep 29 - Sep 30
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
A bedroom with a bed, a nightstand, a bedside table, a floor lamp, a ceiling fan, and a sliding door leading to a bathroom.

12. Welcoming 4-bedroom house with AC in charming La Center

Welcoming 4-bedroom house with AC in charming La Center
La Center
10.0 out of 10, Exceptional, (2 reviews)
"We stayed here while working on a project, and it was honestly one of the best stays I’ve had. The house was super clean, the beds were very comfortable, and the air conditioning worked great. The neighborhood felt safe, the neighbors were friendly, and the location was very convenient with a grocery store just a couple blocks away and a great pizza place nearby.I would definitely stay here again. Highly recommend!"
United States
Tom R.
The price is CA $174
CA $386 total
includes taxes & fees
Sep 29 - Sep 30
Welcoming 4-bedroom house with AC in charming La Center
A single-story house with a gabled roof, a front porch with two chairs, and a front door with a decorative glass panel.

13. Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid
10.0 out of 10, Exceptional, (1 review)
"The host was very quick to respond and so great to work with for on our stay. "
United States
Jessica S.
The price is CA $283
CA $521 total
includes taxes & fees
Oct 1 - Oct 2
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
A covered outdoor area with a grill, chairs, and a table.

14. Come and relax at the Refuge at beautiful Reelfoot Lake!

Come and relax at the Refuge at beautiful Reelfoot Lake!
Hornbeak
9.4 out of 10, Exceptional, (37 reviews)
"Location was great. We were down for a few days fishing."
United States
Andrew
The price is CA $185
CA $343 total
includes taxes & fees
Oct 5 - Oct 6
Come and relax at the Refuge at beautiful Reelfoot Lake!
A kitchen with a stainless steel stove, a range hood, wooden cabinets, and a herringbone wood backsplash.

15. Charming 3-bedroom house with free wifi and coffee it is close to the lake

Charming 3-bedroom house with free wifi and coffee it is close to the lake
Hornbeak
10.0 out of 10, Exceptional, (11 reviews)
"This place was great! It has everything you need and the neighborhood was quiet. The beautiful view of the lake makes it very peaceful! "
United States
Jamie M.
The price is CA $223
CA $394 total
includes taxes & fees
Oct 11 - Oct 12
Charming 3-bedroom house with free wifi and coffee it is close to the lake
A large, single-story building with two open garage-style doors, surrounded by trees with autumn foliage.

16. Guest house and spacious shop located between Discovery Park and Reelfoot Lake

Guest house and spacious shop located between Discovery Park and Reelfoot Lake
Union City
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful place to relax. Home has everything you need. The additional party barn is an added bonus!!"
United States
william P.
The price is CA $356
CA $545 total
includes taxes & fees
Sep 29 - Sep 30
Guest house and spacious shop located between Discovery Park and Reelfoot Lake
A covered patio with a white bench, a glass table, and a fan.

17. Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR

Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR
Hornbeak
9.8 out of 10, Exceptional, (63 reviews)
"Very clean and very helpful host"
United States
Whitney C.
The price is CA $204
CA $368 total
includes taxes & fees
Sep 29 - Sep 30
Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR
A kitchen with wooden cabinets, a stainless steel refrigerator, a built-in oven, and a large window.

18. 3-bedroom house in charming Tiptonville with cool AC and washer and dryer

3-bedroom house in charming Tiptonville with cool AC and washer and dryer
Tiptonville
10.0 out of 10, Exceptional, (1 review)
"Easy to get along with and great communication. "
United States
Shane W.
The price is CA $191
CA $333 total
includes taxes & fees
Sep 29 - Sep 30
3-bedroom house in charming Tiptonville with cool AC and washer and dryer
A small, single-story mobile home with a covered porch and a sign that reads "THE HUT".

19. The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed

The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed
Hornbeak
9.8 out of 10, Exceptional, (60 reviews)
"Great place to stay! Clean and convenient location what more can you ask for! "
United States
Austin E.
The price is CA $177
CA $340 total
includes taxes & fees
Sep 29 - Sep 30
The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed
A compact RV interior with a kitchenette, a seating area, and a window providing a view outside.

20. Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.

Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
La Center
The price is CA $64
CA $136 total
includes taxes & fees
Sep 29 - Sep 30
Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent
"Everything was great clean helpful Everything friendly."
Kathleen 1-night trip
Posted 6 hours ago
The Riverstone Hotel Charleston-Sikeston

Find out more about Mississippi County

Everything you need to know about Mississippi County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mississippi County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mississippi County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Mississippi County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Mississippi County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Mississippi County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Mississippi County vacation rentals we have selected for you start as low as CA $199 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Mississippi County rentals

At Expedia, we put the best Mississippi County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Mississippi County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mississippi County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mississippi County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.