Defiance Vacation Rentals

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Vacation Rentals in Defiance

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (94)
"Our second year in a row and we love this place! It is perfect for a girls trip."
The price is CA $159
CA $333 total
includes taxes & fees
May 5 - May 6
St. Charles 1860's Gem - Sleeps 6!

Value Suites Extended Stay - St Louis

3.0 star property
7.0 out of 10, Good, (1110)
"We’ve stayed here twice before and have always been pleased with everything. Very good hotel close to what we need."
The price is CA $128
CA $262 total
includes taxes & fees
May 4 - May 5
Value Suites Extended Stay - St Louis

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

10.0 out of 10, Exceptional, (200)
"This property is within easy walking distance to ALL of historic downtown St Charles. It's obvious the owners take great care in keeping The Guest House in perfect condition, with every possible amenity provided. Very comfortable stay. We'll absolutely be back!"
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome

9.0 out of 10, Wonderful, (46)
"Everything was perfect. Thank you so much for everything. "
The price is CA $303
CA $594 total
includes taxes & fees
May 1 - May 2
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome

Authentic Log cabin with something for everyone!

9.6 out of 10, Exceptional, (354)
"Great stay in a beautiful log cabin. Two wonderful porches to relax, eat and enjoy the view. Very spacious and clean. Our furry friends felt right at home too. The country setting is perfect for privacy and relaxation. Would stay again "
Authentic Log cabin with something for everyone!

The Lofts of North Main Street

9.6 out of 10, Exceptional, (130)
"Great location for a visit to old at charles"
The price is CA $178
CA $363 total
includes taxes & fees
May 5 - May 6
The Lofts of North Main Street

Beautiful Villa Close to All St. Louis Attractions!

9.2 out of 10, Wonderful, (49)
"Warm and cozy setting."
The price is CA $242
CA $412 total
includes taxes & fees
May 13 - May 14
Beautiful Villa Close to All St. Louis Attractions!

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (54)
"Delightful stay! Home is beautifully appointed, cozy, in a charming neighborhood very close to Main Street shopping/dining and more. We thoroughly enjoyed our stay."
The price is CA $220
CA $494 total
includes taxes & fees
May 1 - May 2
Stunning 1890's Home - Sleeps 8!

Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

10.0 out of 10, Exceptional, (24)
"Donna was very nice and the home was perfect for my group’s stay!"
The price is CA $899
CA $1,465 total
includes taxes & fees
May 4 - May 5
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!

10.0 out of 10, Exceptional, (90)
"Had a great stay at the cabin. We enjoyed the nearby trails and the hot tub was a hit. Kitchen was well equipped for our cooking needs. "
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!

3BR Historic St. Charles, MO-Walking distance to Main Street

9.0 out of 10, Wonderful, (2)
"Beautiful property that seems as if it was very recently completed. Would definitely stay again. Every host provides different "nice to have" items; my only comment would be that a few items such as shampoo, dish cloths, basic spices such as salt & pepper would have been great. Overall great place."
The price is CA $277
CA $743 total
includes taxes & fees
May 8 - May 9
3BR Historic St. Charles, MO-Walking distance to Main Street

AK's STL Pearl Grey House - Game Room

10.0 out of 10, Exceptional, (2)
"Quiet neighborhood, comfortable house, well-stocked kitchen. We would stay here again."
The price is CA $292
CA $650 total
includes taxes & fees
May 5 - May 6
AK's STL Pearl Grey House - Game Room

Residence on the Roundabout

9.6 out of 10, Exceptional, (126)
"Enjoyed the comfort of this little house while we explored all there is to do in St Charles "
Residence on the Roundabout

Escape the city to quiet and picturesque Golden Eagle, IL..

10.0 out of 10, Exceptional, (342)
"Another great stay! Thank you!"
Escape the city to quiet and picturesque Golden Eagle, IL..

Cozy Cottage, we're told it's heavenly!

10.0 out of 10, Exceptional, (187)
"Very much enjoyed our stay, will recommend to others!"
Cozy Cottage, we're told it's heavenly!

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (126)
"Annual book weekend with family. The bed downstairs was so amazing for lounging and reading all weekend. We had an amazing time! "
The St. Charles Guest House, lovely historic home, fun for families and groups

🌷RARE NEW TREASURE🌷2 Homes+Outdoor Gathering Area. Two Blocks From Main St.!!!

9.2 out of 10, Wonderful, (10)
"Had a great time together! Really enjoyed spending time around the fire pit!"
🌷RARE NEW TREASURE🌷2 Homes+Outdoor Gathering Area. Two Blocks From Main St.!!!

Cozy and Comfortable Home in West County

10.0 out of 10, Exceptional, (55)
"Enjoyed our own place while in-town to visit family. The place was perfect for how small family who spent our nights here but weren't hosting."
Cozy and Comfortable Home in West County

Villa in Eureka 1- mile to Hidden Valley & Six Flags

9.0 out of 10, Wonderful, (65)
"I like that it was in a not too busy area, easy to navigate and get where we wanted to be."
The price is CA $207
CA $368 total
includes taxes & fees
May 1 - May 2
Villa in Eureka 1- mile to Hidden Valley & Six Flags

Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

10.0 out of 10, Exceptional, (58)
"The chalet was impeccably maintained and had everything we needed for a relaxing stay. Highly recommend this property as the location is convenient and the view is perfect! "
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other types of properties in Defiance you may be interested in

Hollywood Casino & Hotel St. Louis

3.5 star property
8.4 out of 10, Very good, (1884)
"Great stay"
The price is CA $137
CA $180 total
includes taxes & fees
May 5 - May 6
Hollywood Casino & Hotel St. Louis

Ameristar Casino Resort and Spa

4.5 star property
8.4 out of 10, Very good, (1001)
"Everything was very clean, restaurants were good, and staff was awesome."
The price is CA $234
CA $296 total
includes taxes & fees
May 4 - May 5
Ameristar Casino Resort and Spa

The Wildwood Hotel

3.5 star property
9.0 out of 10, Wonderful, (1484)
"Great room, great service, great location! "
The price is CA $122
CA $148 total
includes taxes & fees
May 5 - May 6
The Wildwood Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

St. Charles 1860's Gem - Sleeps 6!: This vacation home rental outside of Defiance is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.