Defiance Vacation Rentals

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Vacation Rentals in Defiance

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (66)
"Beautiful house and location."
The price is CA $267
CA $550 total
includes taxes & fees
Jul 17 - Jul 18
Stunning 1890's Home - Sleeps 8!

Cowboy Cabin, come sit under the trees

10.0 out of 10, Exceptional, (196)
"Enjoyed the cabin and the ambiance! Very clean and comfortable. The fireplace is awesome Rain kept us from enjoying the deck and the property but we hope to come back soon. "
Cowboy Cabin, come sit under the trees

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (129)
"We very much enjoyed the property and location. "
The St. Charles Guest House, lovely historic home, fun for families and groups

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

10.0 out of 10, Exceptional, (202)
"Beautiful cottage in the perfect location. "
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

2.0 star property
7.8 out of 10, Good, (19)
"The property was quiet and as expected. They were incredibly responsive and helpful with everything. "
The price is CA $92
CA $188 total
includes taxes & fees
Jul 17 - Jul 18
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

Private Cabin on 90 Acres!

10.0 out of 10, Exceptional, (4)
"We enjoyed our stay in this peaceful cabin, the atmosphere was great for a date nite and the hot tube was very relaxing. "
Private Cabin on 90 Acres!

☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome

8.8 out of 10, Excellent, (53)
"Great stay with family! "
The price is CA $300
CA $588 total
includes taxes & fees
Jul 17 - Jul 18
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome

Honky Tonk Hideaway

9.2 out of 10, Wonderful, (5)
"Great place to stay"
The price is CA $123
CA $351 total
includes taxes & fees
Jul 16 - Jul 17
Honky Tonk Hideaway

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (43)
"Great house. Lots of room. Walkable to main st"
The price is CA $184
CA $459 total
includes taxes & fees
Jul 17 - Jul 18
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Innsbrook Falls Hideaway - Roomy lakefront Chalet w/ spacious deck & firepit

10.0 out of 10, Exceptional, (25)
"We thoroughly enjoyed our stay at Innsbrook Falls Hideaway. The chalet was very clean and spacious for the six of us. The setting was serene and having the kayaks to explore and fish were a nice addition. The ping pong table provided extra entertainment along with the many game options that were available. The snack basket that included treats for our dog was a nice touch."
Innsbrook Falls Hideaway - Roomy lakefront Chalet w/ spacious deck & firepit

Cozy Lakefront Chalet - On A Large Lake - Private Dock w/Boats

10.0 out of 10, Exceptional, (74)
"Wonderful family getaway!"
Cozy Lakefront Chalet - On A Large Lake - Private Dock w/Boats

Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

9.6 out of 10, Exceptional, (49)
"Lovely home within a neighborhood subdivision. Clean, beautifully decorated, plenty of bedrooms and bathroom for our group. Close to restaurants and shopping. "
The price is CA $245
CA $551 total
includes taxes & fees
Jul 16 - Jul 17
Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

Prime Loft of Main Street

9.8 out of 10, Exceptional, (92)
"Fantastic place and location!"
The price is CA $159
CA $334 total
includes taxes & fees
Jul 15 - Jul 16
Prime Loft of Main Street

Residence on the Roundabout

9.6 out of 10, Exceptional, (130)
"We had a nice stay in this cute home. St. Charles is a wonderful place to visit! "
Residence on the Roundabout

Cozy Cottage, we're told it's heavenly!

10.0 out of 10, Exceptional, (194)
"My fiancé and I had the best time during our stay! This was our second time visiting and loved it. We enjoyed relaxing on the deck and walking around the property with our pups. "
Cozy Cottage, we're told it's heavenly!

Authentic Log cabin with something for everyone!

9.6 out of 10, Exceptional, (360)
"It was a perfect place for our family to spend the weekend of my son’s wedding. The location was perfect, and the views of the lake in the mornings was stunning."
Authentic Log cabin with something for everyone!

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (108)
"Great time and nice and quiet :) "
The price is CA $171
CA $342 total
includes taxes & fees
Jul 16 - Jul 17
St. Charles 1860's Gem - Sleeps 6!

FLAT, Lakefront chalet; Hottub, Playground, Firepit, Wifi, and more!

10.0 out of 10, Exceptional, (33)
"Great place! Plan to book again."
FLAT, Lakefront chalet; Hottub, Playground, Firepit, Wifi, and more!

Beautiful Villa Close to All St. Louis Attractions!

9.0 out of 10, Wonderful, (52)
"Warm and cozy setting."
The price is CA $240
CA $412 total
includes taxes & fees
Jul 15 - Jul 16
Beautiful Villa Close to All St. Louis Attractions!

Peaceful chalet - *new* private beach, WIFI, kayaks

10.0 out of 10, Exceptional, (64)
"Excellent stay!! We couldn’t be more happy with our weekend, would recommend to anyone!"
Peaceful chalet - *new* private beach, WIFI, kayaks
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

Stunning 1890's Home - Sleeps 8! : This vacation home rental outside of Defiance has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.