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Defiance Vacation Rentals

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Vacation Rentals in Defiance

The Lofts of North Main Street
9.6 out of 10, Exceptional, 90 reviews
"Photos don't do it justice. This was the perfect place to stay for me and my family during my college graduation weekend. The accommodations are a perfect balance between chic, cozy, and modern. There was plenty of space for all 5 of us to spread out and relax. We never felt like we were crowded or had too little privacy. The upstairs loft is a neat spot to chill or to sleep, and in the living room/dining room/kitchen area we could visit while watching TV, eating, and cooking/cleaning in the...
The price is CA $162
CA $347 total
includes taxes & fees
Jun 19 - Jun 20
The Lofts of North Main Street
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome
9.0 out of 10, Wonderful, 41 reviews
"My friends had a good time on our weekend stay. The neighborhood and neighbors were really nice. The outdoor area was a bonus, we liked the patio and yard space for outdoor activities. The house had everything we needed and were even provided extra toiletries. My only complaint would be the sleeping arrangements, the pull out bed wasn’t comfortable but we doubled up on mattresses and it worked out fine."
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome
Craigshire Suites
3.0 star property
7.0 out of 10, Good, 1,110 reviews
"Great customer service "
The price is CA $168
CA $195 total
includes taxes & fees
Jul 6 - Jul 7
Craigshire Suites
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Cozy Cottage, we're told it's heavenly!
10.0 out of 10, Exceptional, 150 reviews
"The host goes the extra mile in making sure that everything is provided for! We enjoyed the experience."
Cozy Cottage, we're told it's heavenly!
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
10.0 out of 10, Exceptional, 185 reviews
"We could walk to the riverfront, walking paths, shops and restaurants!"
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
10.0 out of 10, Exceptional, 38 reviews
"We enjoyed our stay and loved the close proximity to Main Street. The downstairs shower could use an upgrade but other than that the house was warm and cozy."
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
Residence on the Roundabout
9.6 out of 10, Exceptional, 106 reviews
"Close to all St. Charles shopping. Close to St. Louis , the loop. We have stayed here twice . And will be back . Cute place for 4 adults or a family . Fenced yard , close to a park ."
Residence on the Roundabout
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
10.0 out of 10, Exceptional, 186 reviews
"Forty family members gathered in the St. Louis area for my mom's 93rd birthday. Many of us were minutes away from each other along Main Street in St. Charles. It was a perfect location for us since we are all walkers and foodies. The Red Barn Guesthouse was a perfect fit for the 6 of us!"
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
Historic headquarters of city founder! Gated parking!
10.0 out of 10, Exceptional, 14 reviews
"I can’t say enough good things about this property and its host! Lynn is so responsive and gives wonderful recommendations for the area! The location is perfect and close distance to walk to many local stores and eateries! The home is decorated absolutely preciously in historic fashion, and cleanliness is immaculate! I wouldn’t stay anywhere else! I adored this perfect historic get away! :)"
Historic headquarters of city founder! Gated parking!
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!
10.0 out of 10, Exceptional, 221 reviews
"We felt like we stepped back in time staying in a small cottage in the cobblestone street of Old St Charles."
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!
The St. Charles Guest House, lovely historic home, fun for families and groups
10.0 out of 10, Exceptional, 107 reviews
"This house was perfect for our family to hang out and hit Main Street in St. Charles. The house itself has an updated kitchen and bathrooms and has enough space for a big family chill and watch movies or play video games. It is within walking distance of all the attractions on Main Street and if you are up to it, the Ameristar casino."
The St. Charles Guest House, lovely historic home, fun for families and groups
Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft
9.6 out of 10, Exceptional, 7 reviews
"Nice property. Excellent host. Very accommodating"
The price is CA $184
CA $425 total
includes taxes & fees
Jun 10 - Jun 11
Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
10.0 out of 10, Exceptional, 52 reviews
"Very clean and comfortable chalet. The kids had an amazing time. Dining is very limited but the kitchen has all the essentials. "
The price is CA $613
CA $1,028 total
includes taxes & fees
Jun 24 - Jun 25
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Escape the city to quiet and picturesque Golden Eagle, IL..
10.0 out of 10, Exceptional, 312 reviews
"This was our second stay. We love the peacefulness and beauty of this area. The home was so comfortable! Such warm and generous hosts!"
Escape the city to quiet and picturesque Golden Eagle, IL..
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.
10.0 out of 10, Exceptional, 238 reviews
"We loved theguesthouse it was such a nice place and clise to everything"
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
10.0 out of 10, Exceptional, 68 reviews
"The house was in a remote quiet location on a pretty lake. Very very clean and well appointed. Wonderful firepit and firewood provided. But the second bedroom is actually a loft open to below! Very surprised as the listing called it a 2 bedroom! Overall a great house at Innsbrook!"
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
Authentic Log cabin with something for everyone!
9.6 out of 10, Exceptional, 316 reviews
"We liked the cabin and my grandkids like feeding the fish and playing in the water.There where just 2 things that bothered me.The black ants where bad and the kitchen oven was really dirty.Other than that we enjoyed our stay very much."
Authentic Log cabin with something for everyone!
Remodeled Kirkwood Guest house
10.0 out of 10, Exceptional, 56 reviews
"My wife and I were looking to get away and relax for a few days and we found the perfect place. Our host was incredibly accommodating, the town is amazing and only a short and delightful walk away. My only regret is that we didn’t stay longer. We will definitely be back."
Remodeled Kirkwood Guest house
Cowboy cabin, March availability, look for discounted weekly rates!
10.0 out of 10, Exceptional, 164 reviews
"We love it here! We’ve been coming here for 10 years and the property and grounds have just grew and became more and more beautiful!"
Cowboy cabin, March availability, look for discounted weekly rates!
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
10.0 out of 10, Exceptional, 8 reviews
"Refreshing retreat for our small church. Relaxing. Everything we needed was there. Open floor plan made time together better. The fireplace and views are amazing."
The price is CA $855
CA $1,424 total
includes taxes & fees
Jun 13 - Jun 14
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
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See all available properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Vacation Rental Travel Info

Number of vacation rentals
3
Popular accommodation
Defiance cabins
Known landmarks
Augusta Winery, Chandler Hill Vineyards and Montelle Winery
International airport
St. Louis, MO (STL-Lambert-St. Louis Intl.)

Other types of properties in Defiance you may be interested in

Hollywood Casino & Hotel St. Louis
3.5 star property
8.2 out of 10, Very good, 1,219 reviews
"Na"
The price is CA $151
CA $189 total
includes taxes & fees
Jun 9 - Jun 10
Hollywood Casino & Hotel St. Louis
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 star property
4.6 out of 10, 1,014 reviews
"Good"
The price is CA $88
CA $102 total
includes taxes & fees
Jun 16 - Jun 17
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 star property
7.6 out of 10, Good, 1,017 reviews
"I stayed at this LaQuinta 6 years ago and liked it. I was disappointed this time. The hot tub they used to have got paved over. The first room I was given smelled so strongly of ammonia that I couldn’t use it. The second room smelled like industrial cleaner and gave me a headache. The bathtub had a loud consistent drip. There were sticky stains just outside of the door. A maintenance worker pounded on the door next to mine and called maintenance so loudly I thought it was for me. That gave me...
The price is CA $107
CA $124 total
includes taxes & fees
Jun 23 - Jun 24
La Quinta Inn & Suites by Wyndham St. Louis Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Everything you need to know about Defiance vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Defiance vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Defiance vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Defiance vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Defiance. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Defiance vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Defiance vacation rentals we have selected for you start as low as CA $162 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Defiance rentals

At Expedia, we put the best Defiance vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Defiance rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Defiance vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Defiance. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals where you'll be just 9.8 mi (15.8 km) from Six Flags St. Louis, providing a secluded option if you'd like a quiet spot to stay. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This vacation home rental outside of Defiance is located on a river and offers a fireplace, air-conditioning, and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What’s there to see and do in Defiance?

Missouri River and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.

Recent reviews of Defiance properties
Expedia verified reviews