De Soto Vacation Packages

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

Top De Soto Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo St Louis - Central West End by IHG
The Wildwood Hotel
Hotel Saint Louis, Autograph Collection
DoubleTree by Hilton Hotel St. Louis - Chesterfield
The Cheshire

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

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De Soto Hotel Deals

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
The price is CA $193 per night from Feb 15 to Feb 16
CA $193
CA $366 total
Feb 15 - Feb 16
includes taxes & fees
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (63 reviews)
This place was fantastic! Just pack your clothes and food—everything else is provided. We truly enjoyed our stay at the cabin and can’t wait to return. Thank you for the great hospitality.

Reviewed on Jan 2, 2026

Secluded cabin on private property
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is CA $74 per night from Feb 24 to Feb 25
CA $74
CA $84 total
Feb 24 - Feb 25
includes taxes & fees
7.8/10 Good! (1,003 reviews)
Very clean room and personnel from the desk to cleaning personnel were so nice! Smoke free. Good experience.

Reviewed on Feb 5, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.