Title: Antofagasta Region Vacations & Trips 2026  | Expedia.ca

[Antofagasta Region Travel Guide](https://expedia.ca/Antofagasta-Region.dx6236581)[Antofagasta Region Hotels](https://expedia.ca/Destinations-In-Antofagasta-Region.d6236581.Hotel-Destinations)[Vacation Rentals in Antofagasta Region](https://expedia.ca/Destinations-In-Antofagasta-Region.d6236581.Vacation-Rental-Destinations)[Antofagasta Region Car Rentals](https://expedia.ca/Destinations-In-Antofagasta-Region.d6236581.Car-Rental-Destinations)

![](https://images.trvl-media.com/place/6236581/9414dc4e-7e44-41c7-94b4-9f4e29cb4210.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Antofagasta Region Vacation Packages

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to CA $1,096 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Top vacation destinations in Antofagasta Region

![](https://images.trvl-media.com/place/500224/5f28f0e3-efc0-4c0d-af16-a54cebbf23e5.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### San Pedro de Atacama

[](https://expedia.ca/San-Pedro-De-Atacama.d500224.Destination-Travel-Guides)

![Adobe](https://images.trvl-media.com/place/382/92e596c7-b25d-4347-8312-784825dcea16.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Antofagasta

[](https://expedia.ca/Antofagasta.d382.Destination-Travel-Guides)

![Valle de Muerte - Atacama desert near San Pedro (chile)](https://images.trvl-media.com/place/847/5ecbeda6-2452-48ed-aad2-878cd27e8b7b.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Calama

[](https://expedia.ca/Calama.d847.Destination-Travel-Guides)

## Antofagasta Region Hotel Deals

![Diego de Almagro San Pedro de Atacama](https://images.trvl-media.com/lodging/2000000/1110000/1100500/1100408/ae70d540_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Diego de Almagro San Pedro de Atacama

Toconao 460 San Pedro de Atacama Antofagasta

Fully refundableReserve now, pay when you stay

CA $174

CA $174 total

May 4 - May 5

8.2/10 Very Good! (364 reviews)

Large beds

Reviewed on Mar 24, 2026

[](https://expedia.ca/Hotel-Search?startDate=04%2F05%2F2026&endDate=05%2F05%2F2026&selected=1100408&PinnedHotelID=1100408&HadPinnedHotel=true&regionId=6236581)

![Our Habitas Atacama](https://images.trvl-media.com/lodging/6000000/5520000/5516800/5516748/8c2cc01d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Our Habitas Atacama

Domingo Atienza 282 San Pedro de Atacama Antofagasta

Fully refundableReserve now, pay when you stay

CA $338

CA $338 total

Apr 26 - Apr 27

8.6/10 Excellent! (338 reviews)

Es un buen hotel.

Reviewed on Apr 1, 2026

[](https://expedia.ca/Hotel-Search?startDate=26%2F04%2F2026&endDate=27%2F04%2F2026&selected=5516748&PinnedHotelID=5516748&HadPinnedHotel=true&regionId=6236581)

![Hotel La Casa de Don Tomas](https://images.trvl-media.com/lodging/16000000/15170000/15162500/15162410/0ba0d357_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel La Casa de Don Tomas

Calle Tocopilla Sitio 18 San Pedro de Atacama 

Fully refundableReserve now, pay when you stay

CA $291

CA $291 total

May 3 - May 4

9.2/10 Wonderful! (399 reviews)

Nice room with porch to enjoy afternoon pleasant surroundings. Facilities including dining area, pool and outside sitting areas were very comfortable and the service staff was very attentive and helpful.

Reviewed on Mar 2, 2026

[](https://expedia.ca/Hotel-Search?startDate=03%2F05%2F2026&endDate=04%2F05%2F2026&selected=15162410&PinnedHotelID=15162410&HadPinnedHotel=true&regionId=6236581)

[See all 308 properties in Antofagasta Region](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=04%2F04%2F2026&endDate=05%2F04%2F2026&regionId=6236581)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Family Vacations

[](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

## Frequently asked questions

### How much does an Antofagasta Region vacation package cost?

### How do I get a cheap travel package to Antofagasta Region?

### What are the top hotels in Antofagasta Region?

### How far in advance should I book my Antofagasta Region vacation?

### What does an Expedia Antofagasta Region travel package include?

### What should I know before booking an Antofagasta Region travel package?

### Can I choose my airline with an Antofagasta Region Expedia vacation package?

### If I'm not able to travel, can I cancel my Antofagasta Region vacation package?

### Discover the most popular places to visit in Antofagasta Region

![Valley of the Moon](https://images.trvl-media.com/place/6098516/dcc47ea9-6e77-4a74-b4ab-c885b853b18c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Valley of the Moon

Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.

[](https://expedia.ca/Valley-Of-The-Moon-San-Pedro-de-Atacama.d6098516.Vacation-Attraction)

#### Plaza de San Pedro de Atacama

You can find out about the history of San Pedro de Atacama when you stop by Plaza de San Pedro de Atacama. You can seek out the local tours in this quaint area. 

[](https://expedia.ca/Plaza-De-San-Pedro-De-Atacama-San-Pedro-de-Atacama.d6098510.Vacation-Attraction)

#### Piedra del Coyote Overlook

Explore the great outdoors at Piedra del Coyote Overlook, a lovely green space in San Pedro de Atacama. You can seek out the local tours in this quaint area. 

[](https://expedia.ca/Piedra-Del-Coyote-Overlook-San-Pedro-de-Atacama.d6314541.Vacation-Attraction)

### What to do in Antofagasta Region

![San Pedro de Atacama: Stargazing Experience with Transfer](https://mediaim.expedia.com/localexpert/48194324/ffbc2e78-0a1d-4cdd-9146-23bcdd47e560.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### San Pedro de Atacama: Stargazing Experience

CA $48

per adult

[](https://expedia.ca/things-to-do/san-pedro-de-atacama-stargazing-experience.a48194324.activity-details)

![Astronomical Experience with Astrophotography in Atacama](https://mediaim.expedia.com/localexpert/47663431/e0cac369-ceff-472d-bea7-51668b3ac5f4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Astronomical Experience with Astrophotography in Atacama

CA $58

per adult

[](https://expedia.ca/things-to-do/astronomical-experience-with-astrophotography-in-atacama.a47663431.activity-details)

![Tour to the Valley of the Moon San Pedro de Atacama](https://mediaim.expedia.com/localexpert/5267485/b0932526-d7c9-48de-b4fa-e76de43c1569.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Tour to the Valley of the Moon San Pedro de Atacama

CA $48

per adult

**94%** of travellers recommend

[](https://expedia.ca/things-to-do/tour-to-the-valley-of-the-moon-san-pedro-de-atacama.a5267485.activity-details)

[See all activities in Antofagasta Region](https://expedia.ca/things-to-do/search?rid=6236581)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app