Upstate South Carolina Vacation Packages

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Your Upstate South Carolina Vacation

With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.

Top Upstate South Carolina Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Comfort Suites University - Research Park

Comfort Suites University - Research Park

2.5 out of 5
University City
Price was CA $1,021, price is now CA $818 per person
CA $818
per person
Oct 10 - Oct 14
found 7 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Charlotte (CLT)
7.6/10 Good! (1,003 reviews)
Had to relocate to this hotel and it was a blessing.

Reviewed on Aug. 25, 2025

Charlotte Marriott City Center

Charlotte Marriott City Center

4 out of 5
Uptown Charlotte
Price was CA $1,312, price is now CA $962 per person
CA $962
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Charlotte (CLT)
8.8/10 Excellent! (1,002 reviews)
The hotel is in a great location. The staff was super friendly. We were greeted coming and going. The guy who checked us in was SUPER! The room does need some maintenance, but most of the time, we were in and out. We will definitely stay again.

Reviewed on Sep. 1, 2025

The Westin Charlotte

The Westin Charlotte

4 out of 5
Uptown Charlotte
Price was CA $1,273, price is now CA $940 per person
CA $940
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Charlotte (CLT)
9/10 Wonderful! (1,000 reviews)
Nice hotel but the rooms were dated and lacked some modern amenities.

Reviewed on Aug. 21, 2025

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
Greenville Downtown
Price was CA $3,366, price is now CA $2,560 per person
CA $2,560
per person
Oct 15 - Oct 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Greenville (GSP)
9.6/10 Exceptional! (378 reviews)
The staff at this facility are the best I’ve ever dealt with at a hotel. The room was very spacious and clean. Very impressed with the whole experience at the Grand Bohemian.

Reviewed on Aug. 24, 2025

Hyatt House Charlotte/Rea Farms

Hyatt House Charlotte/Rea Farms

3 out of 5
Price was CA $1,082, price is now CA $884 per person
CA $884
per person
Oct 10 - Oct 14
found 7 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Charlotte (CLT)
9.4/10 Exceptional! (700 reviews)
This is a lovely hotel in a very nice area with about everything you could want close by. The 4-star rating was given bc we enrolled in World of Hyatt at suggestion of hotel reception & when I enquirer about a sign on bonus of $15K points being offered was told she thought it was a scam & we didn’t receive them. Then, our plans got changed and we had to add 3 more nights, but had to check out & check back in to go to a different room bc there were no more queen doubles available. That would’ve been ok, but we were given a King suite at a higher rate and STILL no Hyatt points bonus given. Would expect a little bit more customer appreciation. The breakfast eggs weren’t real eggs otherwise an ‘ok’ breakfast as hotel offerings go. Rooms, beds were very good and beds comfortable. Would choose it again when in Charlotte.

Reviewed on Sep. 2, 2025

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville which includes autumn leaves, a garden and a bridge

Greenville Downtown

3 out of top 10 points of interest in this area
5/5(3 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

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Upstate South Carolina Hotel Deals

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is CA $131 per night from Sep 6 to Sep 7
CA $131
CA $148 total
Sep 6 - Sep 7
includes taxes & fees
Hilton Greenville
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is CA $197 per night from Sep 14 to Sep 15
CA $197
CA $223 total
Sep 14 - Sep 15
includes taxes & fees
Hyatt Regency Greenville
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson
Get rates
Wooded Cottage - 3 Mi to Clemson University
See all 2,835 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Upstate South Carolina

Fred W. Symmes Chapel

Fred W. Symmes Chapel

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

Fred W. Symmes Chapel

Greenville Convention Center

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

Greenville Convention Center

Wofford College

Take a campus tour or just explore the area of Wofford College, during your trip to Spartanburg. Experience the area's theater scene or attend a sporting event.

Wofford College

What to do in Upstate South Carolina

Just Desserts Tour In Greenville

Just Desserts Tour In Greenville

CA $131
per adult
Just Desserts Tour In Greenville
Paranormal Walking Tour by Greenville Ghost Tours

Paranormal Walking Tour by Greenville Ghost Tours

CA $48
per adult
Paranormal Walking Tour by Greenville Ghost Tours
Delicious breakfast on a sunny Saturday morning on the terrace

Small-Group Walking Tour in Greenville with Breakfast

CA $131
per adult
100% of travellers recommend
Small-Group Walking Tour in Greenville with Breakfast
See all activities in Upstate South Carolina
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.