Title: Hotels by Independent in Upstate South Carolina from CA $74 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![Falls Park in the middle of downtown! Beautiful place to relax, set up a hammock, play in the water and listen to the falls. ](https://images.trvl-media.com/place/1388/9768cca7-241b-46cc-9044-0389ae1e8a0a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Rachel Evan # Find Hotels by Independent in Upstate South Carolina from CA $74 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina Independent ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/91e6d418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/589bd84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1001) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gene CA $150 CA $186 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/f1cbacdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/34438b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/01f08951.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn @ Clemson [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) Clemson 8.0/10 Very good (1004) "Very good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/91df3d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, body treatments, body wraps, body scrubs](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/4bf90c6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/d2844575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/32050804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Hartness [](https://www.expedia.ca/Greenville-Hotels-Hotel-Hartness.h89689223.Hotel-Information) Greenville 9.8/10 Exceptional (625) "Beautiful location, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew CA $208 CA $276 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Greenville-Hotels-Hotel-Hartness.h89689223.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/96000000/95670000/95668200/95668169/a8a1fed9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95670000/95668200/95668169/834e3d3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/96000000/95670000/95668200/95668169/402009cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exercise/lap pool](https://images.trvl-media.com/lodging/96000000/95670000/95668200/95668169/86c1e212.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Greenville Inn and Suites [](https://www.expedia.ca/Greenville-Hotels-1314-S-Pleasantburg-Dr.h95668169.Hotel-Information) Greenville 6.0/10 (164) "Front desk ladies are nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert [](https://www.expedia.ca/Greenville-Hotels-1314-S-Pleasantburg-Dr.h95668169.Hotel-Information) ![Golf](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/ad943919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10:00 AM to 9:00 PM, free cabanas](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/8fa71ed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/0aec11f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/63d829f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson University's James F. Martin Inn [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) Clemson 9.6/10 Exceptional (960) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mindi CA $205 CA $228 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/020b11bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/4ea5cb8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/71449a4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/1611bef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Horizon Inn & Suites [](https://www.expedia.ca/Anderson-Hotels-Horizon-Inn-Suites.h6496.Hotel-Information) Anderson 4.6/10 (235) "Motel for crackheads" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryan CA $63 CA $74 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Anderson-Hotels-Horizon-Inn-Suites.h6496.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Custom King Full](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/179daec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/a5d6b89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) Clemson 9.6/10 Exceptional (557) "location is amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) colleen [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/cb83efe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/959a330b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/893b2bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) Clemson 9.8/10 Exceptional (781) "Clean room. Nice front desk concierge. Very cute hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anisha CA $205 CA $228 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/120000/116600/116562/48c989d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/120000/116600/116562/8deac1ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/120000/116600/116562/a0150f81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cleanliness standards](https://images.trvl-media.com/lodging/1000000/120000/116600/116562/62faa057.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Greenville Pelham Inn by IHG [](https://www.expedia.ca/Greenville-Hotels-Econo-Lodge-Suites-Greenville.h116562.Hotel-Information) Greenville 7.2/10 Good (882) "Great location and room size. Internet was great for work related needs. Great hotel staff also" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roy CA $83 CA $91 total includes taxes & fees Jan 12 - Jan 13, 2026 [](https://www.expedia.ca/Greenville-Hotels-Econo-Lodge-Suites-Greenville.h116562.Hotel-Information) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/61217476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/cc01b08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/2d11b158.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/464c71ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### stayAPT Suites Greenville-Haywood Mall [](https://www.expedia.ca/Greenville-Hotels-StayAPT-Suites-Greenville-Haywood-Mall.h69716747.Hotel-Information) Greenville 9.0/10 Wonderful (196) "Great place!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daecia CA $145 CA $159 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Greenville-Hotels-StayAPT-Suites-Greenville-Haywood-Mall.h69716747.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-27&endDate=2025-12-28®ionId=6057939&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Independent.0-0-d6057939--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Independent.0-0-d6057939--bIndependent.Travel-Guide-Filter-Hotels) ## Top Upstate South Carolina Hotel Reviews ![La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1fc30205_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. 10/10 Excellent "Great staff, professional and helpful. Very clean rooms." [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "The room was immaculate. TV wouldn't change from the menu screen, that would be my only complaint. " [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Homewood Suites by Hilton Greenville Downtown](https://images.trvl-media.com/lodging/30000000/29060000/29050100/29050020/88b33cc2_y.jpg) ### Homewood Suites by Hilton Greenville Downtown 10/10 Excellent "Beautiful! Easy check-in, on site garage for self parking $18\. Would definitely recommend for. A visit to the city. " [](https://expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville-Downtown.h29050020.Hotel-Information) ![ECHO Suites Extended Stay by Wyndham Spartanburg](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d_y.jpg) ### ECHO Suites Extended Stay by Wyndham Spartanburg 10/10 Excellent "I was impressed upon entrance to the lobby! Everything was clean in neat and the receptionist was AWESOME!" [](https://expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg) ### Grand Bohemian Lodge Greenville, Autograph Collection 10/10 Excellent "Gorgeous, clean, unique, so special!!" [](https://expedia.ca/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![Drury Inn & Suites Greenville](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Very nice amenities and rooms. Staff was super friendly and very helpful when needed. We will definitely stay at another Drury Inn when traveling or needing a hotel" [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 10/10 Excellent "Staff was great, awesome customer service! " [](https://expedia.ca/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "Clean room, friendly staff and nice breakfast!! " [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 10/10 Excellent "Amazing staff and clean room" [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Best Western Hotels in Aiken ](https://www.expedia.ca/Aiken-Hotels-Best-Western.0-0-d6058112--bBestWestern.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Brookhaven ](https://www.expedia.ca/Brookhaven-Hotels-Motel-6.0-0-d553248635975852330--bMotel6.Travel-Guide-Filter-Hotels) - [Starwood Capital Hotels in Central ](https://www.expedia.ca/Central-Hotels-Starwood-Capital.0-0-d10503--bStarwoodCapital.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Clover ](https://www.expedia.ca/Clover-Hotels-Motel-6.0-0-d3000455892--bMotel6.Travel-Guide-Filter-Hotels) - 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