Independent Hotels in Upstate South Carolina
South Carolina
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An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Find Hotels by Independent in Upstate South Carolina from CA $101

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Hotels recommended for families in Upstate South Carolina

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

A modern kitchen with a central island, three bar stools, pendant lighting, and a decorative flower arrangement.

A pool area with lounge chairs and a sign for Best Western Plus.

A hotel room with a large bed, a desk with a chair, a blue armchair, a wooden nightstand with a lamp, and a wardrobe with a mirror.

Best Western Plus Greenville I-385 Inn & Suites

2.5 star property

Greenville

9.2 out of 10, Wonderful, (1,615)

9.2/10

Wonderful

(1,615)

The price is CA $107

CA $107

CA $118 total

includes taxes & fees

Dec 6 - Dec 7

Best Western Plus Greenville I-385 Inn & Suites

A modern kitchen with hanging light fixtures and bar seating.

A hotel courtyard with outdoor seating, stone pillars, and a modern building in the background.

A modern bar area with a central island, bar stools, and overhead lighting.

A modern lobby with a curved reception desk, a large TV screen, a sofa, and several chairs.

DoubleTree by Hilton Greenville Woodruff Road

3.0 star property

Greenville

9.2 out of 10, Wonderful, (1,001)

9.2/10

Wonderful

(1,001)

The price is CA $147

CA $147

CA $167 total

includes taxes & fees

Nov 22 - Nov 23

DoubleTree by Hilton Greenville Woodruff Road

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

An outdoor patio with a stone fire pit, wicker chairs, and a pergola structure.

A spacious lobby with modern furniture, a reception desk, and a decorative ceiling design.

An indoor swimming pool with lounge chairs and potted plants.

Embassy Suites Greenville Golf Resort & Conference Center

3.5 star property

Greenville

9.0 out of 10, Wonderful, (1,483)

9.0/10

Wonderful

(1,483)

The price is CA $151

CA $151

CA $171 total

includes taxes & fees

Nov 23 - Nov 24

Embassy Suites Greenville Golf Resort & Conference Center

A modern hotel room with a large bed, a desk, and a kitchenette.

A hotel entrance with stone facade, American flag, and a sign for Microtel Inn & Suites by Wyndham.

A modern lobby with a blue accent wall, a flat-screen TV, a reception desk, and two grey armchairs.

A compact living space with a kitchenette, a flat-screen TV, a sofa, and a bed with a patterned cover.

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

2.0 star property

Greenville

8.4 out of 10, Very good, (1,006)

8.4/10

Very good

(1,006)

The price is CA $102

CA $102

CA $112 total

includes taxes & fees

Nov 29 - Nov 30

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

A spacious hotel lobby with a reception desk, seating area, and a large plant.

An indoor swimming pool with a checkered floor, lounge chairs, and a view of the sky through the ceiling.

A bartender pouring a drink into a martini glass.

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 star property

Greenville

8.6 out of 10, Excellent, (1,005)

8.6/10

Excellent

(1,005)

The price is CA $135

CA $135

CA $153 total

includes taxes & fees

Nov 23 - Nov 24

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

A modern living room with a fireplace, a flat-screen TV, and comfortable seating.

A reception area with two reception desks, a large cityscape poster, and a plant.

A modern kitchen with a refrigerator, coffee machine, and various food items.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

3.0 star property

Greenville

8.8 out of 10, Excellent, (416)

8.8/10

Excellent

(416)

The price is CA $133

CA $133

CA $151 total

includes taxes & fees

Dec 7 - Dec 8

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

An outdoor patio area with a fire feature, wicker furniture, and potted plants.

A store named 'The Shop' with a variety of snacks, beverages, and packaged goods.

A modern kitchen with a central island, bar area, and breakfast service counter.

Hilton Garden Inn Greenville

3.0 star property

Greenville

8.8 out of 10, Excellent, (1,000)

8.8/10

Excellent

(1,000)

The price is CA $139

CA $139

CA $157 total

includes taxes & fees

Nov 22 - Nov 23

Hilton Garden Inn Greenville

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a red accent wall.

A modern hotel lobby with a wooden cabinet, a flat-screen TV, a sofa, and a table.

A modern restaurant with high ceilings, large windows, and a mix of seating options including booths and tables.

Drury Inn & Suites Greenville

3.0 star property

Greenville

9.4 out of 10, Exceptional, (1,096)

9.4/10

Exceptional

(1,096)

The price is CA $164

CA $164

CA $181 total

includes taxes & fees

Nov 23 - Nov 24

Drury Inn & Suites Greenville

Top Upstate South Carolina Hotel Reviews

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.

A bar with multiple shelves of liquor bottles and glasses hanging above.

A modern living room with a fireplace, seating area, and a bar with shelves of bottles.

A large, two-story house with a symmetrical facade, large windows, and a central entrance.

Hotel Hartness

Greenville

10/10 Excellent

What a gem!! Definitely the place to stay when in Greenville, or even to visit specifically as a vacation. It’s not in the city (about 15min drive) and that’s the beauty of this place: it’s away from touristy stuff, and in the middle of nature, but close enough to the city that you can always go and visit. The service was 6 star! All the staff were super friendly, and while a part of it is “southern hospitality “, there for sure is an added factor of the culture of the hotel. Great dining...

anshu

Reviewed July 7, 2025Reviewed July 7, 2025

Hotel Hartness

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

An outdoor patio with wicker furniture, a round table, and a fountain.

The Shepherd Hotel Downtown Clemson

Clemson

10/10 Excellent

Very good hotel.

Matthew

Reviewed January 23, 2025Reviewed January 23, 2025

The Shepherd Hotel Downtown Clemson

A hotel entrance with a stone facade, a wooden door, and potted plants.

A two-story building with a brick facade, a central entrance with a curved arch, and a balcony on the second floor.

A living room with a fireplace, a television mounted above it, and two sofas with floral cushions.

A restaurant with wooden ceiling beams, stone walls, and red patterned curtains. Tables are set with white tablecloths and candles.

The Bleckley Inn

Anderson

10/10 Excellent

This is a first class property!! Extremely clean!!! Breakfast options could be better.

Mike

Reviewed May 10, 2023Reviewed May 10, 2023

The Bleckley Inn

An outdoor patio with a modern design, featuring a seating area with sofas and a fire pit, surrounded by plants and under a pergola with hanging lights.

A modern interior with a bar area, seating, and a staircase.

A modern hotel lobby with a central seating area, a long reception desk, and a kitchen area visible to the right.

A bar area with a central island, multiple bar stools, hanging spherical light fixtures, and a stone pillar.

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

10/10 Excellent

Everything great

Robert

Reviewed November 29, 2025Reviewed November 29, 2025

SpringHill Suites by Marriott Greenville Downtown

A covered outdoor area with a grill and seating, surrounded by brick walls and windows.

A modern hotel lobby with a seating area featuring a sofa and round tables, large windows, and contemporary lighting fixtures.

An indoor swimming pool with clear water, surrounded by a brick building with multiple windows and outdoor seating areas.

A multi-story building with a prominent corner entrance, large windows, and a street intersection with traffic lights.

Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

10/10 Excellent

Very nice

Richard

Reviewed January 13, 2026Reviewed January 13, 2026

Homewood Suites by Hilton Greenville Downtown

A modern restaurant with a brick wall, wooden ceiling beams, and a central seating area with tables and chairs.

An outdoor patio with a fire pit, seating area, and a TV.

An outdoor pool area with seating and umbrellas.

A hallway with a wooden wall, a large abstract sculpture, and patterned flooring.

Hampton Inn Greer Greenville, SC

Greer

10/10 Excellent

Great

Matthew

Reviewed August 25, 2026Reviewed August 25, 2026

Hampton Inn Greer Greenville, SC

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

A bar area with a counter, multiple chairs, and a display of bottles and glasses.

The Abernathy of Clemson

Clemson

10/10 Excellent

Didn't clean on next to last day.

Thomas

Reviewed May 30, 2025Reviewed May 30, 2025

The Abernathy of Clemson

Drury Inn & Suites Greenville

Greenville

10/10 Excellent

Wonderful hotel and staff. I bit of a strange smell in the room though. Too bad because everything else was great.

Melodie

Reviewed April 6, 2026Reviewed April 6, 2026

Drury Inn & Suites Greenville

A hotel entrance with a stone facade, a bench, and a trash bin.

A Holiday Inn Express & Suites hotel with a modern design, featuring a brick facade and multiple windows.

A hotel lobby with a reception desk, seating areas, and a corridor leading to other rooms.

An outdoor patio area with tables and chairs, a building with large windows, and a clear sky.

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

10/10 Excellent

The mattress was a bit uncomfortable but the pillows were very comfortable

Cindy

Reviewed September 7, 2026Reviewed September 7, 2026

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

A multi-level hotel lobby with seating areas, a fireplace, and a staircase.

A spacious lobby with a high ceiling, modern furniture, and large windows offering views of the outdoors.

A modern coffee bar with a glass display case, seating area with round tables and chairs, and a wooden ceiling.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and wooden panel walls.

Four Points by Sheraton Spartanburg

Spartanburg

10/10 Excellent

No microwave in the room

JOSE

Reviewed July 17, 2026Reviewed July 17, 2026

Four Points by Sheraton Spartanburg

DoubleTree by Hilton Greenville Woodruff Road

Greenville

10/10 Excellent

Clean rooms and amazing staff

Shaunette

Reviewed May 8, 2026Reviewed May 8, 2026

DoubleTree by Hilton Greenville Woodruff Road

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Find Hotels by Independent in Upstate South Carolina from CA $101

Change your mind

Treat yourself

Be picky

Check prices for these dates

Hotels recommended for families in Upstate South Carolina

Best Western Plus Greenville I-385 Inn & Suites

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

10/10 Excellent

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