Name: 21C Museum Hotel St Louis
Price range: CA $231
Rating: 9

Your Uplands Park Vacation

When a city getaway is calling, answer it with a vacation package to Uplands Park. The neighborhood of Downtown St. Louis, which is great for festivals, bars and pubs and dining, makes a fantastic base for your adventures. A trip to Uplands Park is a superb opportunity to do a bit of sightseeing. Be sure to visit renowned attractions like St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis. Stop dreaming and start adventuring. Browse the range of options on Expedia today and finally put your Uplands Park vacation plans into motion!

Top Uplands Park Vacation Deals

Price found within the past 48 hours. Click for updated prices.

The Cheshire

CA $938

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

8.8/10 Excellent! (1,006 reviews)

It has a very quaintly English theme. Very unique and fun.

Reviewed on May 8, 2026

The Royal Sonesta Chase Park Plaza St. Louis

Central West End

CA $1,001

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

9/10 Wonderful! (1,011 reviews)

This was a weekend staycation for my wife and I and as usual we were not disappointed. Very helpful staff and excellent accommodations.

Reviewed on May 4, 2026

Tru By Hilton St. Louis Downtown

Downtown West

CA $1,006

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

7.6/10 Good! (723 reviews)

We loved our stay here! Will definitely be back. The rooms were clean and the beds were comfy. It was a great price, too!!

Reviewed on May 7, 2026

Hilton St. Louis at the Ballpark

Downtown St. Louis

CA $1,270

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

7.6/10 Good! (1,125 reviews)

The staff was incredible. They helped get our bags in and out of the room

Reviewed on May 5, 2026

Home2 Suites by Hilton St. Louis Downtown

Downtown West

CA $1,020

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

8/10 Very Good! (750 reviews)

The rooms were clean. The breakfast was very good with a nice selection of food to choose from. The staff was very helpful and friendly.

Reviewed on May 7, 2026

Ready to book your vacation to Uplands Park?

Choose your dates

Uplands Park Hotel Deals

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

CA $173

CA $204 total

May 25 - May 26

includes taxes & fees

8.6/10 Excellent! (4,060 reviews)

Very clean

Reviewed on May 8, 2026

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

CA $136

CA $158 total

May 17 - May 18

includes taxes & fees

8.8/10 Excellent! (3,194 reviews)

None

Reviewed on May 8, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

CA $231

CA $277 total

May 10 - May 11

includes taxes & fees

9/10 Wonderful! (1,823 reviews)

Really cool hotel with great onsite bar/restaurant, gym, pool and art gallery.

Reviewed on May 6, 2026

See all 1,868 properties in Uplands Park

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.