Photo by Meredith Breckner
All hotels in Defiance, St. Louis
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
All hotels in Defiance, St. Louis
We have found 790 Defiance Hotels
- Hollywood Casino & Hotel St. Louis
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- The Wildwood Hotel
- Ameristar Casino Resort and Spa
- Sonesta ES Suites St. Louis - Chesterfield
- Drury Plaza Hotel St. Louis Chesterfield
- Best Western Plus St. Louis West-Westport
- Elimwood Hotel, A Ramada by Wyndham
- Comfort Inn St Louis – Airport
- Hyatt Place St. Louis/Chesterfield
- Embassy Suites by Hilton St. Louis St. Charles
- Crowne Plaza St. Louis Airport, an IHG Hotel
- Drury Inn & Suites St. Louis Creve Coeur
- Country Inn & Suites by Radisson, St. Charles, MO
- DoubleTree by Hilton Hotel St. Louis - Chesterfield
- Hilton St. Louis Frontenac
- Pear Tree Inn St. Louis Fenton
- Drury Inn & Suites Southwest St. Louis
- Extended Stay America Suites St Louis Airport Central
- Country Inn & Suites by Radisson, St. Peters, MO
- Drury Plaza Hotel St. Louis St. Charles
- Americas Best Value Inn & Suites St. Louis, St. Charles Inn
- Comfort Suites St Charles - St Louis
- Homewood Suites by Hilton St. Louis-Chesterfield
- Comfort Inn St. Louis - Westport Event Center
- Comfort Inn & Suites St. Louis - O'Fallon
- Comfort Inn & Suites St. Louis - Chesterfield
- Hampton Inn St. Charles St. Peters
- Sleep Inn & Suites O'Fallon MO - Technology Drive
- SureStay Plus by Best Western Fenton
- Courtyard by Marriott St Louis Westport Plaza
- SpringHill Suites by Marriott St. Louis Airport/Earth City
- Sonesta Simply Suites St Louis Earth City
- Drury Inn & Suites St. Louis St. Peters
- Relax Inn Saint Charles
- Hampton Inn St. Louis/Chesterfield
- Motel 6 Maryland Heights, MO
- Drury Inn & Suites St. Louis Fenton
- DoubleTree by Hilton St. Louis - Westport
- Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel
- Homewood Suites by Hilton St. Louis Riverport - Airport West
- Super 8 by Wyndham St Charles
- Courtyard by Marriott St. Louis Chesterfield
- Extended Stay America Suites St Louis Westport E Lackland Rd
- Staybridge Suites O'Fallon Chesterfield, an IHG Hotel
- Extended Stay America Select Suites St Louis Earth City
- Super 8 by Wyndham O'Fallon MO/St. Louis Area
- Economy Inn Wentzville
- Tru by Hilton St. Charles St. Louis, MO
- Holiday Inn Express & Suites St. Louis - Chesterfield, an IHG Hotel
- Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel
- Extended Stay America Suites St Louis St Peters
- Extended Stay America Suites - St Louis - Fenton
- Comfort Inn Near Six Flags St. Louis
- Embassy Suites by Hilton St. Louis Airport
- Holiday Inn Express Hotel and Suites St. Charles, an IHG Hotel
- Courtyard St. Louis Airport/Earth City
- WoodSpring Suites St Louis St Charles
- Quality Inn Near Six Flags St. Louis
- Residence Inn by Marriott St Louis Airport
- The Lodge Hotel and Banquets
- Hampton Inn St. Louis Southwest
- Fairfield Inn & Suites by Marriott St. Louis Chesterfield
- Courtyard by Marriott St. Louis St. Peters
- Courtyard by Marriott St. Louis West County
- Fairfield Inn & Suites St Louis Westport
- Residence Inn by Marriott O'Fallon
- Sheraton Westport Chalet Hotel St. Louis
- Best Western Plus Washington Hotel
- Fairfield Inn & Suites Wentzville
- Super 8 by Wyndham Union
- Hampton Inn St. Louis/Westport
- Super 8 by Wyndham Washington
- Marriott St. Louis West
- Baymont by Wyndham Warrenton
- Super 8 by Wyndham St. Clair MO
- Quality Inn
- BEST WAY INN
- Days Inn by Wyndham St Peters/St Charles
- Hilton Garden Inn St. Louis/O'Fallon MO
Let Expedia take you to the best Hotels in Defiance. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.