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Our top choices for Southampton hotels

1. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 1.5 km from Southampton
8.6 out of 10, Excellent, (2,252 reviews)
The price is CA $119
CA $141 total
includes taxes & fees
Nov 23 - Nov 24

2. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 1.6 km from Southampton
9.2 out of 10, Wonderful, (1,286 reviews)
The price is CA $168
CA $209 total
includes taxes & fees
Nov 22 - Nov 23

3. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3 km from Southampton
9.2 out of 10, Wonderful, (2,735 reviews)
The price is CA $177
CA $208 total
includes taxes & fees
Nov 15 - Nov 16

4. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 2.4 km from Southampton
8.4 out of 10, Very good, (1,976 reviews)
The price is CA $119
CA $139 total
includes taxes & fees
Nov 22 - Nov 23

5. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 3.1 km from Southampton
9.2 out of 10, Wonderful, (1,008 reviews)
The price is CA $150
CA $176 total
includes taxes & fees
Nov 20 - Nov 21

6. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3 km from Southampton
9.2 out of 10, Wonderful, (1,288 reviews)
The price is CA $177
CA $208 total
includes taxes & fees
Nov 26 - Nov 27

7. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.9 km from Southampton
8.8 out of 10, Excellent, (1,000 reviews)
The price is CA $145
CA $171 total
includes taxes & fees
Nov 15 - Nov 16

8. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 1.5 km from Southampton
7.8 out of 10, Good, (1,752 reviews)
The price is CA $95
CA $111 total
includes taxes & fees
Nov 22 - Nov 23

9. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium3.7 km from Southampton
8.8 out of 10, Excellent, (1,010 reviews)
The price is CA $125
CA $146 total
includes taxes & fees
Dec 2 - Dec 3

10. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG4.4 km from Southampton
9.4 out of 10, Exceptional, (1,001 reviews)
The price is CA $167
CA $196 total
includes taxes & fees
Nov 16 - Nov 17

11. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 2.7 km from Southampton
9.0 out of 10, Wonderful, (3,827 reviews)
The price is CA $207
CA $243 total
includes taxes & fees
Nov 22 - Nov 23

12. Hotel Ylem
Hotel Ylem3.2 km from Southampton
8.2 out of 10, Very good, (1,596 reviews)
The price is CA $97
CA $120 total
includes taxes & fees
Nov 25 - Nov 26

13. Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaGreater Uptown, 5.6 km from Southampton
9.0 out of 10, Wonderful, (1,095 reviews)
The price is CA $149
CA $175 total
includes taxes & fees
Nov 22 - Nov 23

14. Drury Inn & Suites Houston Near the Galleria
Drury Inn & Suites Houston Near the GalleriaThe Galleria, 5.4 km from Southampton
9.4 out of 10, Exceptional, (1,586 reviews)
The price is CA $162
CA $190 total
includes taxes & fees
Nov 15 - Nov 16

15. Best Western Plus Downtown Inn & Suites
Best Western Plus Downtown Inn & Suites5 km from Southampton
9.2 out of 10, Wonderful, (1,121 reviews)
The price is CA $169
CA $198 total
includes taxes & fees
Nov 22 - Nov 23

16. Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownMidtown, 4.8 km from Southampton
9.2 out of 10, Wonderful, (280 reviews)
The price is CA $127
CA $149 total
includes taxes & fees
Nov 22 - Nov 23

17. Cambria Hotel Houston Downtown Convention Center
Cambria Hotel Houston Downtown Convention CenterHouston Central Business District, 6.3 km from Southampton
9.0 out of 10, Wonderful, (1,950 reviews)
The price is CA $109
CA $127 total
includes taxes & fees
Nov 23 - Nov 24

18. Hyatt Place Houston Downtown
Hyatt Place Houston DowntownHouston Central Business District, 6.2 km from Southampton
9.0 out of 10, Wonderful, (1,703 reviews)
The price is CA $198
CA $235 total
includes taxes & fees
Dec 4 - Dec 5

19. The Whitehall Houston
The Whitehall HoustonHouston Central Business District, 5 km from Southampton
8.6 out of 10, Excellent, (2,520 reviews)
The price is CA $139
CA $162 total
includes taxes & fees
Dec 12 - Dec 13

20. Holiday Inn Express Houston Downtown by IHG
Holiday Inn Express Houston Downtown by IHGDowntown Houston, 6.4 km from Southampton
9.4 out of 10, Exceptional, (202 reviews)
The price is CA $167
CA $201 total
includes taxes & fees
Nov 22 - Nov 23
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in Southampton
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Hilton Houston Plaza/Medical Center | 8.6 Excellent 2,252 reviews | View | ||||||
![]() DoubleTree by Hilton Hotel Houston - Greenway Plaza | 8.4 Very good 1,976 reviews | View | ||||||
![]() Hyatt Place Houston Medical Center | 9.2 Wonderful 2,735 reviews | View | ||||||
![]() Hyatt House Houston Medical Center | 9.2 Wonderful 1,288 reviews | View | ||||||
![]() InterContinental Houston by IHG | 9.4 Exceptional 1,007 reviews | View |
Where to stay in Southampton
Find the best Southampton areas and neighborhoods for the activities you enjoy most.

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top Southampton Hotel Reviews

Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center
























































































