Title: Book the Best Seneca SPA Resorts from CA $133 - Spa Hotels in Seneca, SC | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # Find Spa Hotels in Seneca, SC from CA $133 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca Spa Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-04&endDate=2025-11-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-05&endDate=2025-11-06&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seneca Spa Hotels We don't have any properties that match your exact search [See all properties in Seneca](https://expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20®ionId=6548&adults=2) ## Recommended hotels in Seneca ![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/c9812bb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/ad885ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/405dd7c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/511c9b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy Clemson TIny House Cabin Seneca CA $176 CA $304 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/d191b963.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/01158bad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson Seneca 9.0/10 Wonderful (1011) "Great place to stay while visiting our Tiger! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cristina CA $153 CA $190 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/3c50d204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/270-2efd6ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/347fe1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 Downtown 8.0/10 Very good (654) "Ok hotel for a quick stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lori CA $113 CA $133 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/83901eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/65f927f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Microwave (with Sofabed)](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/188dc421.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seneca-Clemson Seneca 8.4/10 Very good (627) "Convenient for Clemson visits." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathleen CA $125 CA $138 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Balcony](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/9fe06894.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/cc35e730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/a9307e7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/e45ab30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Seneca Clemson Univ Area Seneca 9.4/10 Exceptional (201) "Beautiful clean hotel. Staff was very welcoming. Breakfast area was very clean with many options. The river view is so beautiful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $169 CA $186 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/ac7a917f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible (Hearing, Roll-In Shower)](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/d36e662a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Seneca Clemson Seneca 9.2/10 Wonderful (779) "Very friendly and clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $148 CA $162 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/313b57b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/877edfc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/ce65516b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Seneca-Clemson Area Seneca 9.4/10 Exceptional (649) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose CA $180 CA $198 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/f5941a87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/18a62d98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Cabin, 1 Queen Bed](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/361e76b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy Seneca 9.8/10 Exceptional (46) "The place was absolutely magnificent." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $181 CA $261 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/e0c6bce4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/094cb5d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/d703ded8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/7a250fe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC Seneca 10/10 Exceptional (9) "Great place and even better hosts! This place is unique and will make you never want to stay in a hotel again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Court H. CA $162 CA $291 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Seneca-Hotels-Charming-1-Bedroom-Farmhouse-In-Marvelous-Seneca-With-WiFi.h118111429.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/e2588273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/d8eac253.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/137ba22d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/c5a2afe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly! Seneca 10/10 Exceptional (12) "Very clean and comfortable - very close to Clemson and easy access. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jim A. CA $211 CA $281 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20®ionId=6548&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Seneca Hotel Reviews ![Hampton Inn & Suites Seneca-Clemson Area](//images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "All good. " [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ## Frequently asked questions ### How much does a spa hotel in Seneca cost? > Enjoy staying in a spa hotel in Seneca, with plenty of hotels from CA $133 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, and may vary depending on the location, season, and hotel amenities. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a trip during the weekend or around public holidays. ### Is it cheaper to book a spa hotel in Seneca with flights as part of a package deal? > Booking a hotel and flight package on Expedia can be cheaper than booking flights and hotels separately. Bundling can lead to significant savings, especially for international travel or when booking well in advance. However, savings vary depending on factors like destination, travel dates, and availability, so it's wise to compare options. With access to over 300,000 hotels worldwide, Expedia makes it easy to build the perfect [travel package](https://www.expedia.ca/Seneca.d6548.Destination-Travel-Guides). ### Are there any unique spa experiences available in Seneca? > Yes, Seneca, South Carolina offers several unique spa experiences, particularly through specialised aesthetic and wellness clinics. > > > > Jocassee Hydration & Aesthetics in downtown Seneca provides advanced treatments such as facial fillers, microneedling with platelet rich fibrin (PRF), and natural facial treatments. They also offer an "Eye of the Tiger intravenous therapy" designed to boost energy and mood, a distinctive wellness option. > > > > The Refinery Co., an aesthetic clinic, focuses on advanced skin care procedures including chemical peels, diamond dermabrasion facials, and hydrofacials. Their approach combines personalised care with modern technology for a unique medspa experience. > > > > Tony Massage & Salon, LLC and Your Contoured Body also contribute to the local wellness scene, offering massage and body contouring services respectively. ### How can I save on a spa hotel in Seneca with Expedia? > Members always get our best prices. Find our best Seneca spa hotel deals by joining Expedia's free travel rewards program—[One Key™](https://www.expedia.ca/welcome-one-key). As a member, you can unlock instant savings and member perks when you're logged in to your account. For a spontaneous weekend retreat, discover last-minute offers. ### Can I cancel my spa hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline. This is often within 24-48 hours of your scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use Expedia's "Fully refundable property" filter during your search to find the right spa hotel in Seneca for you. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Starwood Capital Hotels in Central](https://www.expedia.ca/Central-Hotels-Starwood-Capital.0-0-d10503--bStarwoodCapital.Travel-Guide-Filter-Hotels) - [Central Hotels](https://www.expedia.ca/Central-Hotels.d10503.Travel-Guide-Hotels) - [Motels in Central](https://www.expedia.ca/Central-Motels.d10503-aaMotels.Travel-Guide-Accommodation) - [Resorts in Central](https://www.expedia.ca/Central-Resort-Hotels.d10503-aaResortHotels.Travel-Guide-Accommodation) - [Aparthotels in Clemson](https://www.expedia.ca/Clemson-Apart-Hotels.d6594-aaApartHotels.Travel-Guide-Accommodation) - 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