Title: Seneca Vacation Rentals from CA $235: Short-Term Rentals for 2025 | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # Seneca Vacation Rentals ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Vacation Rentals in Seneca ![Exterior](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/f29b16c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/18a62d98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Cabin, 1 Queen Bed](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/361e76b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy Seneca 9.8/10 Exceptional (43) "The place was absolutely magnificent." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $180 CA $260 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/58000000/57860000/57854500/57854431/90607bc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/58000000/57860000/57854500/57854431/0a401e88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/58000000/57860000/57854500/57854431/4e88af74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/58000000/57860000/57854500/57854431/f4e6ba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water. Seneca 9.8/10 Exceptional (153) "This property has so much room! Loved the dining room table - great for games and meals. Screened-in porch was wonderful for early mornings and late nights. The garage apartment was nicely done and QUIET! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jay m. [](https://www.expedia.ca/Anderson-Hotels-Newly-Furnished-And-Renovated-Lake-House-Directly-On-Hartwell.h57854431.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/67cc829e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, stereo](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/70a34410.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, stereo](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/cde4fe9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/4d05ab51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock Seneca 9.6/10 Exceptional (174) "Fantastic location, beautiful part of the lake, home very clean and well stocked with almost anything one could need on vacation. We really enjoyed swimming off of the dock and using the kayak provided as well. We had a wonderful time and also very much appreciate our hosts being so responsive to our needs/questions." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela M. [](https://www.expedia.ca/Seneca-Hotels-Quiet-Cove.h27118346.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/58000000/57950000/57941100/57941024/fbdc7d33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/58000000/57950000/57941100/57941024/cc31dc1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/58000000/57950000/57941100/57941024/76c381ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/58000000/57950000/57941100/57941024/87cf30aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New to VRBO! Big water views, private dock, pool table, 15 min Clemson! Seneca 10/10 Exceptional (43) "Went for Easter holiday with family. Perfect location - nice and quiet. Family all had a good visit. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlene R. [](https://www.expedia.ca/Anderson-Hotels-Large.h57941024.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/6343a107.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/7938a48a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/69d09738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/3f48355a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub Seneca 10/10 Exceptional (153) "Owner was very responsive,house is very well maintained and has everything you need supplied. Family had a good time. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) eugene v. [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Waterfront-Home-On-A-Private-Cove-In-Lake-Keowee-W-Hot-Tub.h61640625.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/102000000/101790000/101785400/101785318/5553129d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/102000000/101790000/101785400/101785318/993026f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101790000/101785400/101785318/bb296007.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/102000000/101790000/101785400/101785318/9d625f96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy! Seneca 10/10 Exceptional (16) "We had a wonderful 3 night stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa S. CA $359 CA $869 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Seneca-Hotels-Lakefront-Cabin-On-Lake-Keowee-Kayaks.h101785318.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/fa789e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/d84ad598.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, table tennis, books](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/dd716f92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/ae1a1038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub! Seneca 10/10 Exceptional (90) "Very well Appointed. A beautiful location and lots of activity equipment for after sunbathing in the cove. We had a houseboat rented, so we could cruise the lake. I k was. Dry responsive to my questions and flexible with our bed sutuation" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christine G. [](https://www.expedia.ca/Seneca-Hotels-Modern-Lakefront-Luxury-Oasis-270-Lake-Views-WDock.h61010330.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/23000000/22630000/22624200/22624169/800e2071.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/23000000/22630000/22624200/22624169/07e72eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/23000000/22630000/22624200/22624169/743faef2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/23000000/22630000/22624200/22624169/fbd06d78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water Seneca 9.8/10 Exceptional (155) "Home is located at the perfect spot on Lake Hartwell and well equipped for lake life!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David A. [](https://www.expedia.ca/Anderson-Hotels-Lake-House-Near-Clemson.h22624169.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/be98782f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, DVD player](https://images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/6c3e2356.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/aafd08c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/d8caac21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. Seneca 9.8/10 Exceptional (363) "Enjoyed the property and it is in an excellent location on the lake." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachael S. [](https://www.expedia.ca/Anderson-Hotels-Beautiful-43.h33728167.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102410000/102400600/102400544/be4db389.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/103000000/102410000/102400600/102400544/aff277d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102410000/102400600/102400544/0d8a113a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102410000/102400600/102400544/bc9a6abb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Incredible 10 BR home with pool Seneca 9.6/10 Exceptional (5) "We used this location for a staff off site 2 day meeting. The rooms were fantastic, the outdoor space amazing and the little living spaces for smaller meetings worked well. I think we will definitely use this house again. The property management people were very responsive. Beautiful house!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Molly F. [](https://www.expedia.ca/Seneca-Hotels-Incredible-10-BR-Home-With-Pool.h102400544.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/816aa8b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, foosball, table tennis](https://images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/4d49ee97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, foosball, table tennis](https://images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/8eb743e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/271c0ce6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Large family home with dock on Lake Keowee! Seneca 9.8/10 Exceptional (118) "Perfect family get away" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elise B. [](https://www.expedia.ca/Seneca-Hotels-Large-Family-Home-With-Dock-On-Lake-Keowee.h33743502.Hotel-Information) ![Microwave, stovetop](https://images.trvl-media.com/lodging/119000000/118480000/118477500/118477441/c3793bf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/119000000/118480000/118477500/118477441/3dfb8d2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118480000/118477500/118477441/99d8f2d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118480000/118477500/118477441/1c9db559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fabulous Tiny House with AC in charming Seneca Seneca 9.4/10 Exceptional (6) "I couldn’t have been happier with my stay. Everything was top notch. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lance S. [](https://www.expedia.ca/Seneca-Hotels-Fabulous-Tiny-House-With-AC-In-Charming-Seneca.h118477441.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/w1239h698x3y3-27d6457f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dishwasher](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/edaa5dbe_edited_0c01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dishwasher](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/332a5793_edited_45c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/66a386e2_edited_ecaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock Seneca 10/10 Exceptional (7) "The kitchen is spacious, kitchen is fully stocked, plenty of towels, and a PERFECT location to anchor down and enjoy the fireworks on the lake. We entered the lake through Cane Creek Landing Boat Ramp which is only 7 minutes away. If you prefer more privacy with your family, this location in the cove is ideal." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer B. [](https://www.expedia.ca/Seneca-Hotels-Luxury-4BR4BA-Lake-Keowee-Retreat-Mountain-Cabin-Vibes-Private-Dock.h117764713.Hotel-Information) ![](https://images.trvl-media.com/lodging/19000000/18970000/18968900/18968828/9c91f86d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/19000000/18970000/18968900/18968828/09324013.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/19000000/18970000/18968900/18968828/40f5b0d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/19000000/18970000/18968900/18968828/6097ae54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fall fun at the cabin! Convenient to Lake Keowee and Clemson Seneca 9.0/10 Wonderful (79) "Very peaceful, clean and relaxing. Will definitely go back." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrea R. [](https://www.expedia.ca/Anderson-Hotels-Fall-Fun-At-The-Cabin-Convenient-To-Lake-Keowee-And-Clemson.h18968828.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/119000000/118790000/118789900/118789838/bb2ed37c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/119000000/118790000/118789900/118789838/96720353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118790000/118789900/118789838/650bea2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118790000/118789900/118789838/882045b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NEWLY FURNISHED 4BR/4BA condo 8 mins from Memorial Stadium 15 mins from Clemson! Seneca 10/10 Exceptional (1) "We had a wonderful stay! The home was spotless and very well taken care of, which made it feel so comfortable from the moment we walked in. The location couldn’t be better—close to Clemson University, downtown, and all the local spots we wanted to check out. The host was easy to communicate with and made everything smooth and stress-free. We would definitely stay here again next time we’re in Clemson. This will be our go-to place for Clemson games!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynn C. [](https://www.expedia.ca/Seneca-Hotels-NEWLY-FURNISHED-4BR4BA-Condo-8-Mins-From-Memorial-Stadium-15-Mins-From-Clemson.h118789838.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/19000000/19000000/18992600/18992571/f4add0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/19000000/19000000/18992600/18992571/980f0098.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/19000000/19000000/18992600/18992571/8120701f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/19000000/19000000/18992600/18992571/b220bfb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks Pine Ridge Point 10/10 Exceptional (225) "Beautiful home and property!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brigette F. [](https://www.expedia.ca/Seneca-Hotels-Lake-Front.h18992571.Hotel-Information) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c0b82041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/20e5f478.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/b1844261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c2f5c321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Enjoy one of our RV units son less of a headache for you this vacation! Seneca 7.0/10 Good (2) "Very nice camper in a good location close to Clemson. Perfect for attending games. Took us 10-15 minites to get to stadium. All on back roads.Host was responsive to messages and requests. Only thing I would recommend to host is to reach out a couple days before just to give you check in details. Check in was very simple, but i had to reach to them to get the details. Would definitely stay here again!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hunter P. CA $116 CA $235 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33940000/33932300/33932265/5050461b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/34000000/33940000/33932300/33932265/f93d32fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/34000000/33940000/33932300/33932265/72250b9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/34000000/33940000/33932300/33932265/a67c18a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson. Seneca 9.4/10 Exceptional (72) "Enjoyed the convenient location and the pool on the property. House is a fabulous layout for a large group. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jamise F. [](https://www.expedia.ca/Seneca-Hotels-Lake-House-With-Dock.h33932265.Hotel-Information) ![Cottage (1 Bedroom) | Front of property](https://images.trvl-media.com/lodging/94000000/93540000/93537400/93537325/0b81729b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537400/93537325/6e9d2361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537400/93537325/280ceedc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537400/93537325/57b93fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wooded Cottage - 3 Mi to Clemson University Clemson 10/10 Exceptional (1) [](https://www.expedia.ca/Clemson-Hotels-Pet-Friendly-Central-Cottage-2-Miles-To-Clemson.h93537325.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/116000000/115160000/115150900/115150808/522b0143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115160000/115150900/115150808/beaec53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/116000000/115160000/115150900/115150808/fa96f227.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/116000000/115160000/115150900/115150808/24117b99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy Cove Cabin on Lake Hartwell in Townville SC Townville 10/10 Exceptional (10) "Very nice place, and people, would go again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William B. CA $168 CA $264 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Townville-Hotels-Enchanting-1-Bedroom-Cabin-In-Townville.h115150808.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-07&endDate=2025-11-08®ionId=6548&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals) ## Top Seneca Hotel Reviews ![Tru by Hilton Seneca Clemson](//images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Front desk staff is always so nice and helpful!! This Tru location is consistently good and our absolute go to. Have stayed many times as our child attends Clemson Univ. Can count on it being clean and have everything we need. Great location, near great shopping. Love staying here!" [](https://expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Lakeside Lodge Clemson](//images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Overall a great place to stay. Too bad it's always sold out on a game weekend." [](https://expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. ](//images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/be98782f_y.jpg) ### 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. 10/10 Excellent "The home is located on a beautiful, quiet cove of Lake Keowee. The house was well stocked and comfortable. We had great communication with the hosts and check in was easy. Clemson University is about 30 minutes from the home. " [](https://expedia.ca/Anderson-Hotels-Beautiful-43.h33728167.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](//images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Ok" [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Fairfield Inn & Suites Seneca Clemson Univ Area ](//images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/9fe06894_y.jpg) ### Fairfield Inn & Suites Seneca Clemson Univ Area 10/10 Excellent "Very " [](https://expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](//images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Very accommodating and thoughtfully Put together property. I highly recommend staying here if you like the outdoors but would like to be comfortable." [](https://expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](//images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "All good. " [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub](//images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/6343a107_y.jpg) ### Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub 10/10 Excellent "Great location and experience!" [](https://expedia.ca/Seneca-Hotels-Beautiful-Waterfront-Home-On-A-Private-Cove-In-Lake-Keowee-W-Hot-Tub.h61640625.Hotel-Information) ![Large family home with dock on Lake Keowee! ](//images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/816aa8b2_y.jpg) ### Large family home with dock on Lake Keowee! 10/10 Excellent "Perfect place for family to spread out and have plenty of personal space. Lots of gathering spaces and options for outdoor seating with lake views and use. " [](https://expedia.ca/Seneca-Hotels-Large-Family-Home-With-Dock-On-Lake-Keowee.h33743502.Hotel-Information) ## Find out more about Seneca **Everything you need to know about** **Seneca** **vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.  **Seneca vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Seneca vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Seneca vacation rentals we have selected for you start as low as CA $235 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Seneca rentals** At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.  ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca - All accommodation types in Seneca ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals](https://www.expedia.ca/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Tofino Vacation Rentals](https://www.expedia.ca/Tofino-Vacation-Rentals.d6094955.Travel-Guide-VacationRentals) - [Calgary Vacation Rentals](https://www.expedia.ca/Calgary-Vacation-Rentals.d178245.Travel-Guide-VacationRentals) - [Costa Rica Vacation Rentals](https://www.expedia.ca/Destinations-In-Costa-Rica.d42.Vacation-Rental-Destinations) - [Vancouver Island Vacation Rentals](https://www.expedia.ca/Vancouver-Island-Vacation-Rentals.d6058387.Travel-Guide-VacationRentals) - [Puerto Vallarta Vacation Rentals](https://www.expedia.ca/Puerto-Vallarta-Vacation-Rentals.d180016.Travel-Guide-VacationRentals) - [Hawaii Vacation Rentals](https://www.expedia.ca/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Toronto Vacation Rentals](https://www.expedia.ca/Toronto-Vacation-Rentals.d178314.Travel-Guide-VacationRentals) - [Banff Vacation Rentals](https://www.expedia.ca/Banff-Vacation-Rentals.d10550.Travel-Guide-VacationRentals) - [Penticton Vacation Rentals](https://www.expedia.ca/Penticton-Vacation-Rentals.d4135.Travel-Guide-VacationRentals) - [Osoyoos Vacation Rentals](https://www.expedia.ca/Osoyoos-Vacation-Rentals.d181782.Travel-Guide-VacationRentals) - [Mont Tremblant Vacation Rentals](https://www.expedia.ca/Mont-Tremblant-Vacation-Rentals.d55374.Travel-Guide-VacationRentals) - [Big White Ski Resort Vacation Rentals](https://www.expedia.ca/Big-White-Ski-Resort-Vacation-Rentals.d6058319.Travel-Guide-VacationRentals) - [Ontario Vacation Rentals](https://www.expedia.ca/Destinations-In-Ontario.d11178.Vacation-Rental-Destinations) - [British Columbia Vacation Rentals](https://www.expedia.ca/Destinations-In-British-Columbia.d11117.Vacation-Rental-Destinations) - [Prince Edward Island Vacation Rentals](https://www.expedia.ca/Destinations-In-Prince-Edward-Island.d6058122.Vacation-Rental-Destinations) - [Québec Vacation Rentals](https://www.expedia.ca/Quebec-Vacation-Rentals.d180017.Travel-Guide-VacationRentals) - [Vacation Homes in Seneca](https://expedia.ca/Seneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Cottages in Seneca](https://expedia.ca/Seneca-Cottages.d6548-aaCottages.Travel-Guide-Accommodation) - [Cabin Rentals in Seneca](https://expedia.ca/Seneca-Cabins.d6548-aaCabins.Travel-Guide-Accommodation) - [Apartments in Seneca](https://expedia.ca/Seneca-Apartments.d6548-aaApartments.Travel-Guide-Accommodation) - [Condo Rentals in Seneca](https://expedia.ca/Seneca-Condos.d6548-aaCondos.Travel-Guide-Accommodation) - [Farmstay in Seneca](https://expedia.ca/Seneca-Agritourism.d6548-aaAgritourism.Travel-Guide-Accommodation) - [Motels in Seneca](https://expedia.ca/Seneca-Motels.d6548-aaMotels.Travel-Guide-Accommodation) - [Villas in Seneca](https://expedia.ca/Seneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation) - [RV Parks in Seneca](https://expedia.ca/Seneca-RV-Parks.d6548-aaRVParks.Travel-Guide-Accommodation) - [Lodges in Seneca](https://expedia.ca/Seneca-Lodges.d6548-aaLodges.Travel-Guide-Accommodation) - [B&B in Seneca](https://expedia.ca/Seneca-Bed-And-Breakfast.d6548-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Seneca](https://expedia.ca/Seneca-Guest-Houses.d6548-aaGuestHouses.Travel-Guide-Accommodation) - [Chalets in Seneca](https://expedia.ca/Seneca-Chalets.d6548-aaChalets.Travel-Guide-Accommodation) - [Aparthotels in Seneca](https://expedia.ca/Seneca-Apart-Hotels.d6548-aaApartHotels.Travel-Guide-Accommodation) - [Condo Resorts in Seneca](https://expedia.ca/Seneca-Condominium-Resort.d6548-aaCondominiumResort.Travel-Guide-Accommodation) - [Houseboats in Seneca](https://expedia.ca/Seneca-Houseboats.d6548-aaHouseboats.Travel-Guide-Accommodation) ## Frequently asked questions ### Are there vacation rentals in Seneca? > Yes, there are vacation rentals close to popular attractions in Seneca, or you can select a secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses. ### What's the top vacation rental in Seneca? > [6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.](https://www.expedia.ca/Anderson-Hotels-Newly-Furnished-And-Renovated-Lake-House-Directly-On-Hartwell.h57854431.Hotel-Information): This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. Some other homes for rent in Seneca include [Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock](https://www.expedia.ca/Seneca-Hotels-Luxury-4BR4BA-Lake-Keowee-Retreat-Mountain-Cabin-Vibes-Private-Dock.h117764713.Hotel-Information) and [New to VRBO! Big water views, private dock, pool table, 15 min Clemson!](https://www.expedia.ca/Anderson-Hotels-Large.h57941024.Hotel-Information). ### How many vacation rentals are there in Seneca? > Choose from 203 Expedia vacation rentals in Seneca for a memorable vacation. ### What’s there to see and do in Seneca? > Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Keowee Reservoir and Lake Keowee are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Lake Hartwell are other places worth a visit. ### What’s a vacation rental in Seneca like? > A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)