Lake Keowee South Carolina

Seneca Vacation Rentals

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Our top choices for Seneca vacation rentals

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (80 reviews)
"Awesome place "
United States
Jason
The price is CA $154
CA $232 total
includes taxes & fees
Jul 1 - Jul 2
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Adorable 2-bedroom 1- full bath mobile home with AC close to Lake Keowee, SC

Adorable 2-bedroom 1- full bath mobile home with AC close to Lake Keowee, SC
Seneca
The price is CA $159
CA $289 total
includes taxes & fees
Jun 29 - Jun 30
Adorable 2-bedroom 1- full bath mobile home with AC close to Lake Keowee, SC

Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
The price is CA $347
CA $747 total
includes taxes & fees
Jul 6 - Jul 7
Waterfront 3br home on Lake Hartwell near Clemson

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Seneca
10.0 out of 10, Exceptional, (25 reviews)
"Very nice accommodations and great location for stay in Clemson. "
United States
Marisa G.
The price is CA $197
CA $559 total
includes taxes & fees
Jun 30 - Jul 1
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
The price is CA $177
CA $310 total
includes taxes & fees
Jul 1 - Jul 2
Cozy Clemson TIny House Cabin

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Serenity Bay
9.8 out of 10, Exceptional, (136 reviews)
"Beautiful home, well furnished, very clean, easy TV"
United States
Alan
The price is CA $637
CA $1,147 total
includes taxes & fees
Jun 29 - Jun 30
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Seneca
9.8 out of 10, Exceptional, (62 reviews)
"We had a beautiful stay over Thanksgiving in this very cozy lake house. "
United States
Felicia L.
The price is CA $402
CA $741 total
includes taxes & fees
Jul 22 - Jul 23
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Camping on Fancy-Perfect for small family getaway or couples retreat!

Camping on Fancy-Perfect for small family getaway or couples retreat!
Seneca
The price is CA $102
CA $237 total
includes taxes & fees
Jun 29 - Jun 30
Camping on Fancy-Perfect for small family getaway or couples retreat!

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.6 out of 10, Exceptional, (9 reviews)
"This was a WONDERFUL place, very comfortable and welcoming! The host was accommodating and super responsive! I would stay here again! "
United States
Shauna S.
The price is CA $354
CA $550 total
includes taxes & fees
Jun 28 - Jun 29
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.4 out of 10, Exceptional, (10 reviews)
"Very accommodating host. Property is a great location and very clean. "
United States
Craig F.
The price is CA $480
CA $1,007 total
includes taxes & fees
Jun 24 - Jun 25
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water

Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water
Seneca
10.0 out of 10, Exceptional, (88 reviews)
"Nice location and functionality for family. "
United States
T P.
The price is CA $778
CA $1,334 total
includes taxes & fees
Jun 28 - Jun 29
Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.0 out of 10, Very good, (7 reviews)
"Adorable and clean house! The yard is beautiful "
United States
Diana H.
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
The price is CA $277
CA $515 total
includes taxes & fees
Jul 12 - Jul 13
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (13 reviews)
"Very clean and comfortable - very close to Clemson and easy access. "
United States
Jim A.
The price is CA $212
CA $282 total
includes taxes & fees
Jun 24 - Jun 25
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (3 reviews)
"Great house and host!"
United States
David E.
The price is CA $485
CA $954 total
includes taxes & fees
Jun 24 - Jun 25
The Big Golf House- 10 miles to Clemson

Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
The price is CA $299
CA $555 total
includes taxes & fees
Jul 1 - Jul 2
Carolina Cottage Retreat-12 Minutes from Clemson University

Lake Hartwell 2 bedroom w/ deck & dock! Plenty of parking for boats on trailers

Lake Hartwell 2 bedroom w/ deck & dock! Plenty of parking for boats on trailers
Anderson
The price is CA $229
CA $407 total
includes taxes & fees
Jun 24 - Jun 25
Lake Hartwell 2 bedroom w/ deck & dock! Plenty of parking for boats on trailers

Lake Hartwell Rental w/Dock

Lake Hartwell Rental w/Dock
Fair Play
10.0 out of 10, Exceptional, (58 reviews)
"Michelle and the crew were awesome. I’d recommend staying there to anyone!"
United States
Christopher L.
The price is CA $241
CA $575 total
includes taxes & fees
Jun 30 - Jul 1
Lake Hartwell Rental w/Dock

The Pendle-Tin

The Pendle-Tin
Pendleton
9.8 out of 10, Exceptional, (12 reviews)
"This property was private, in a safe neighborhood so walking was wonderful. It's location was perfect for the event I was attending, It's a short walk to downtown - drive 3-4 minutes"
United States
Karla
The price is CA $125
CA $308 total
includes taxes & fees
Jun 24 - Jun 25
The Pendle-Tin

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
United States
Katlynn
The price is CA $214
CA $355 total
includes taxes & fees
Jul 5 - Jul 6
Carolina Camp Cedar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Seneca vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Seneca vacation rentals we have selected for you start as low as CA $232 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock: This highly rated vacation home rental in Seneca is located on a lake and has a patio, a private yard, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Seneca include 4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly! and Lakefront Treehouse Retreat Minutes from Clemson University!.

How many vacation rentals are there in Seneca?

Choose from 206 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Lake Keowee and Lake Hartwell are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Seneca Historic District are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.