A calm lake with mountains in the background.

Seneca Vacation Rentals

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Our top choices for Seneca vacation rentals

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (93 reviews)
"It was a good getaway trip"
United States
laysha
The price is CA $139
CA $214 total
includes taxes & fees
Aug 17 - Aug 18
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Seneca
10.0 out of 10, Exceptional, (25 reviews)
"Great place to stay. The rooms were clean and we had plenty of space. Definitely would come back!"
United States
Brandon P.
The price is CA $139
CA $478 total
includes taxes & fees
Sep 1 - Sep 2
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

3. Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Beautiful Tiny home! Quiet area where you can sit and enjoy nature, yet convenient to all of the needs you may have while escaping from the hustle & bustle of busy cities. Highly recommend for a quiet honey getaway that beats any hotel experience one could have! 10/10 "
United States
Charlotte C.
The price is CA $175
CA $307 total
includes taxes & fees
Aug 17 - Aug 18
Cozy Clemson TIny House Cabin

4. Iroquois Crossroads - 10 min from Clemson & lakes

Iroquois Crossroads - 10 min from Clemson & lakes
Seneca
The price is CA $164
CA $467 total
includes taxes & fees
Sep 1 - Sep 2
Iroquois Crossroads - 10 min from Clemson & lakes

5. Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"Beautiful home, no complaints."
United States
Brenda
The price is CA $245
CA $486 total
includes taxes & fees
Aug 23 - Aug 24
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

6. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (14 reviews)
"Perfect pet friendly spot to enjoy a weekend getaway! Quiet campground, homey vibe, and awesome location!"
United States
Josie G.
The price is CA $210
CA $281 total
includes taxes & fees
Aug 10 - Aug 11
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

7. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (21 reviews)
"Great host! We had a great experience during our stay. "
United States
David E.
The price is CA $240
CA $535 total
includes taxes & fees
Aug 23 - Aug 24
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

8. Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"We were very pleased with our stay. Four bedrooms was perfect for us. The little coffee bar was an enjoyable perk!"
United States
Karen S.
The price is CA $233
CA $466 total
includes taxes & fees
Aug 16 - Aug 17
Carolina Cottage Retreat-12 Minutes from Clemson University

9. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (11 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
The price is CA $280
CA $485 total
includes taxes & fees
Sep 6 - Sep 7
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

10. Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Seneca
9.8 out of 10, Exceptional, (65 reviews)
"We had a beautiful stay over Thanksgiving in this very cozy lake house. "
United States
Felicia L.
The price is CA $385
CA $740 total
includes taxes & fees
Aug 27 - Aug 28
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

11. Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (14 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
The price is CA $343
CA $740 total
includes taxes & fees
Aug 12 - Aug 13
Waterfront 3br home on Lake Hartwell near Clemson

12. Tucker Farm Cottage on Century Farm

Tucker Farm Cottage on Century Farm
Seneca
10.0 out of 10, Exceptional, (37 reviews)
"Property was clean and beautiful. I wish we could have stayed longer. "
United States
Crystal N.
The price is CA $163
CA $536 total
includes taxes & fees
Aug 13 - Aug 14
Tucker Farm Cottage on Century Farm

13. The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Great house and host!"
United States
David E.
The price is CA $379
CA $876 total
includes taxes & fees
Sep 1 - Sep 2
The Big Golf House- 10 miles to Clemson

14. Johnsons Cove - Lakefront Retreat With EV Charger

Johnsons Cove - Lakefront Retreat With EV Charger
Seneca
10.0 out of 10, Exceptional, (1 review)
"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."
United States
Rebecca G.
The price is CA $501
CA $1,120 total
includes taxes & fees
Sep 3 - Sep 4
Johnsons Cove - Lakefront Retreat With EV Charger

15. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"House was exactly as advertised, very clean and very nice. Was perfect for our stay in Seneca. Highly recommend."
United States
Mark N.
The price is CA $258
CA $536 total
includes taxes & fees
Aug 23 - Aug 24
Renovated 3BR near Lake Keowee & Clemson

16. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.4 out of 10, Exceptional, (10 reviews)
"Everything was lovely."
United States
Allison C.
The price is CA $538
CA $1,074 total
includes taxes & fees
Sep 1 - Sep 2
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

17. The Pendle-Tin

The Pendle-Tin
Pendleton
9.8 out of 10, Exceptional, (12 reviews)
"Cozy, clean & close to campus "
United States
INGRID S.
The price is CA $107
CA $284 total
includes taxes & fees
Aug 11 - Aug 12
The Pendle-Tin

18. Glamping with a partial lake view, 30 minutes to Clemson University

Glamping with a partial lake view, 30 minutes to Clemson University
Westminster
9.4 out of 10, Exceptional, (16 reviews)
"The camper was very clean and the set up was very nice. Didn’t have a view of the lake, but all in all had a very nice stay. "
United States
Scott S.
The price is CA $139
CA $305 total
includes taxes & fees
Aug 17 - Aug 18
Glamping with a partial lake view, 30 minutes to Clemson University

19. Carolina Landing RV Resort - Caravan Park

Carolina Landing RV Resort - Caravan Park
2.0 star property
Fair Play
7.6 out of 10, Good, (50 reviews)
"Very nice stay with friendly staff"
United States
Joseph
The price is CA $192
CA $211 total
includes taxes & fees
Aug 9 - Aug 10
Carolina Landing RV Resort - Caravan Park

20. Residences on Main- Yellow Branch Suite

Residences on Main- Yellow Branch Suite
Walhalla
10.0 out of 10, Exceptional, (19 reviews)
"Very clean and excellent stay, we will definitely be back. "
United States
Deborah F.
The price is CA $106
CA $409 total
includes taxes & fees
Aug 10 - Aug 11
Residences on Main- Yellow Branch Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Find out more about Seneca

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Seneca. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!: This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade game room. Some other homes for rent in Seneca include Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson. and Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub.

How many vacation rentals are there in Seneca?

Choose from 212 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Keowee Reservoir and Lake Keowee are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Lake Hartwell are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.