Seneca Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Seneca vacation rentals

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (71 reviews)
"Great getaway!!!"
United States
Latoya
The price is CA $127
CA $200 total
includes taxes & fees
Jun 9 - Jun 10
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
The price is CA $171
CA $299 total
includes taxes & fees
May 20 - May 21
Cozy Clemson TIny House Cabin

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (13 reviews)
"Very clean and comfortable - very close to Clemson and easy access. "
United States
Jim A.
The price is CA $205
CA $272 total
includes taxes & fees
May 11 - May 12
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
10.0 out of 10, Exceptional, (9 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
The price is CA $335
CA $718 total
includes taxes & fees
May 10 - May 11
Waterfront 3br home on Lake Hartwell near Clemson

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (18 reviews)
"Great home base for a Clemson game. "
United States
Karen A.
The price is CA $192
CA $434 total
includes taxes & fees
May 11 - May 12
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
The price is CA $241
CA $465 total
includes taxes & fees
May 12 - May 13
Carolina Cottage Retreat-12 Minutes from Clemson University

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
7.8 out of 10, Good, (6 reviews)
"Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. "
United States
Alisa W.
The price is CA $224
CA $399 total
includes taxes & fees
May 11 - May 12
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Serenity Bay
9.8 out of 10, Exceptional, (132 reviews)
"Beautiful home, well furnished, very clean, easy TV"
United States
Alan
The price is CA $615
CA $1,108 total
includes taxes & fees
May 12 - May 13
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Absolutely! Perfect space for our needs, so for accommodating for our family & pet. "
United States
Gennifer Q.
The price is CA $323
CA $736 total
includes taxes & fees
May 10 - May 11
The Big Golf House- 10 miles to Clemson

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
The price is CA $228
CA $449 total
includes taxes & fees
May 31 - Jun 1
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.4 out of 10, Exceptional, (9 reviews)
"Very accommodating host. Property is a great location and very clean. "
United States
Craig F.
The price is CA $446
CA $949 total
includes taxes & fees
May 10 - May 11
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Johnsons Cove - Lakefront Retreat With EV Charger

Johnsons Cove - Lakefront Retreat With EV Charger
Seneca
10.0 out of 10, Exceptional, (1 review)
"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."
United States
Rebecca G.
The price is CA $526
CA $1,140 total
includes taxes & fees
May 20 - May 21
Johnsons Cove - Lakefront Retreat With EV Charger

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.6 out of 10, Exceptional, (9 reviews)
"Great place with a lot close by"
United States
Aldor D.
The price is CA $342
CA $534 total
includes taxes & fees
Jun 8 - Jun 9
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

The Pendle-Tin

The Pendle-Tin
Pendleton
10.0 out of 10, Exceptional, (11 reviews)
"Property was cute, cozy and perfect for our short 2 night stay! Clean and distance to campus was great! "
United States
Cindy L.
The price is CA $131
CA $310 total
includes taxes & fees
Jun 9 - Jun 10
The Pendle-Tin

Glamping with a partial lake view, 30 minutes to Clemson University

Glamping with a partial lake view, 30 minutes to Clemson University
Westminster
9.4 out of 10, Exceptional, (14 reviews)
"The camper was very clean and the set up was very nice. Didn’t have a view of the lake, but all in all had a very nice stay. "
United States
Scott S.
The price is CA $135
CA $299 total
includes taxes & fees
May 11 - May 12
Glamping with a partial lake view, 30 minutes to Clemson University

Lake Hartwell Rental w/Dock

Lake Hartwell Rental w/Dock
Fair Play
10.0 out of 10, Exceptional, (57 reviews)
"Michelle and the crew were awesome. I’d recommend staying there to anyone!"
United States
Christopher L.
The price is CA $203
CA $518 total
includes taxes & fees
May 11 - May 12
Lake Hartwell Rental w/Dock

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
United States
Katlynn
The price is CA $217
CA $355 total
includes taxes & fees
May 20 - May 21
Carolina Camp Cedar

Cozy A-frame cabin just 1/4 mile from Lake Hartwell - perfect for anglers

Cozy A-frame cabin just 1/4 mile from Lake Hartwell - perfect for anglers
Townville
10.0 out of 10, Exceptional, (3 reviews)
"Everything was excellent. Perfect place my husband and I for a Clemson football weekend!"
United States
Joyce P.
The price is CA $159
CA $285 total
includes taxes & fees
May 10 - May 11
Cozy A-frame cabin just 1/4 mile from Lake Hartwell - perfect for anglers

Romantic Cottage Getaway, tucked peacefully in the woods

Romantic Cottage Getaway, tucked peacefully in the woods
Pickens
10.0 out of 10, Exceptional, (19 reviews)
"Amazing secluded retreat!"
United States
Stephen N.
The price is CA $220
CA $279 total
includes taxes & fees
May 11 - May 12
Romantic Cottage Getaway, tucked peacefully in the woods

Broyles Landing Cottage at Lake Hartwell SC

Broyles Landing Cottage at Lake Hartwell SC
Townville
10.0 out of 10, Exceptional, (24 reviews)
"Clean, easy to find, plenty of parking"
United States
Anonymous traveller
The price is CA $184
CA $319 total
includes taxes & fees
May 10 - May 11
Broyles Landing Cottage at Lake Hartwell SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Seneca Hotel Reviews

Find out more about Seneca

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Seneca. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!: This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade game room. Some other homes for rent in Seneca include Charming and Entertaining Lake House Retreat for Large Groups! and Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock.

How many vacation rentals are there in Seneca?

Choose from 206 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include Oconee Community Theatre and The Gauntlet, whereas Lake Keowee and Lake Hartwell are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Oconee County Library Seneca Branch are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.