Title: Hotels by Independent in Seneca from CA $80 | Expedia.ca [Seneca Travel Guide](https://expedia.ca/Seneca.dx6548)[Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![An overlooking view in Seneca, South Carolina](https://images.trvl-media.com/place/6548/dae46ccf-db63-4268-bbdf-1e7406fb8f30.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Seneca from CA $80 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 24 - Dec 25](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 25 - Dec 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-25&endDate=2025-12-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca Independent ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/589bd84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/6abd26aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1004) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gene CA $149 CA $185 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/01f08951.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/34438b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/f1cbacdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn @ Clemson [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) Clemson 8.0/10 Very good (1003) "Very good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Golf](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/ad943919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/63d829f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner, brunch served; American cuisine ](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/199642a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/0aec11f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson University's James F. Martin Inn [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) Clemson 9.6/10 Exceptional (961) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mindi CA $204 CA $226 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/020b11bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/71449a4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/4ea5cb8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/1611bef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Horizon Inn & Suites [](https://www.expedia.ca/Anderson-Hotels-Horizon-Inn-Suites.h6496.Hotel-Information) Anderson 4.6/10 (242) "Staff there is awesome " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $68 CA $80 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Anderson-Hotels-Horizon-Inn-Suites.h6496.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Custom King Full](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/179daec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/a5d6b89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) Clemson 9.6/10 Exceptional (557) "location is amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) colleen [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/cb83efe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/959a330b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/d217b18b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) Clemson 9.8/10 Exceptional (785) "Everything was clean staff was courteous and accommodating. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stewart CA $204 CA $226 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Desk, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/920000/910900/910883/c585b741.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/910900/910883/fb1a41d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/920000/910900/910883/7a4f7923.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/920000/910900/910883/741cdd08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Budget Inn Express [](https://www.expedia.ca/Anderson-Hotels-Budget-Inn-Express.h910883.Hotel-Information) Anderson 5.8/10 (239) "This is a quiet tucked away place with a dollar general within walking distance. The staff was friendly and knowledgeable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ashley CA $76 CA $85 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Anderson-Hotels-Budget-Inn-Express.h910883.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4110000/4100300/4100280/2cd8388e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Southern cuisine](https://images.trvl-media.com/lodging/5000000/4110000/4100300/4100280/w666h589x0y0-fc3405d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4110000/4100300/4100280/b07fbe91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4110000/4100300/4100280/554421e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bleckley Inn [](https://www.expedia.ca/Anderson-Hotels-The-Bleckley-Inn.h4100280.Hotel-Information) Anderson 9.8/10 Exceptional (407) "Courteous staff, quiet, beautiful accommodations and great location in Downtown Anderson." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christie [](https://www.expedia.ca/Anderson-Hotels-The-Bleckley-Inn.h4100280.Hotel-Information) ![Hartwell Suites - Suite 1](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/d251378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/w3597h2400x2y0-6da1bac9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hartwell Suites - Suite 1](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/3c48d6cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hartwell Suites - Suite 3](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/w3595h2398x0y2-3c03e92e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hartwell Suites [](https://www.expedia.ca/Hartwell-Hotels-Hartwell-Suites.h102308495.Hotel-Information) Hartwell 9.2/10 Wonderful (24) "Great location, nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danielle [](https://www.expedia.ca/Hartwell-Hotels-Hartwell-Suites.h102308495.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90860000/90859000/90858915/9a82eed8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/91000000/90860000/90859000/90858915/2d4fb967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90860000/90859000/90858915/5a7cef3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90860000/90859000/90858915/8a00ffd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Adorable & recently renovated condo within walking distance to downtown Clemson. [](https://www.expedia.ca/Clemson-Hotels-Adorable-Recently-Renovated-Condo-Within-Walking-Distance-To-Downtown-Clemson.h90858915.Hotel-Information) Clemson 10/10 Exceptional (27) "Great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melanie F. [](https://www.expedia.ca/Clemson-Hotels-Adorable-Recently-Renovated-Condo-Within-Walking-Distance-To-Downtown-Clemson.h90858915.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-07&endDate=2026-01-08®ionId=6548&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Hotels-Independent.0-0-d6548--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Hotels-Independent.0-0-d6548--bIndependent.Travel-Guide-Filter-Hotels) ## Top Seneca Hotel Reviews ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "This hotel was up-to-date, seemingly remodeled recently. I would definitely stay here again. " [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Rooms are clean, nice place" [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/ce467f24_y.jpg) ### Days Inn by Wyndham Anderson 10/10 Excellent "Jennifer was outstanding She was very helpful and suggested a great place to eat Room was very clean and roomy Thanks " [](https://expedia.ca/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Clean rooms, friendly staff, great game room/hang out space. " [](https://expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![ Enjoy one of our RV units son less of a headache for you this vacation!](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c0b82041_y.jpg) ### Enjoy one of our RV units son less of a headache for you this vacation! 10/10 Excellent "My partner and I stayed 5 nights and we enjoyed it so much. It's such a convenient place to reside for a get away. If you're looking for that "outback" feeling but want to be cozy; look no further. Communication was always qick with responses and was more than willing to help with anything we needed! We would definitely stay again." [](https://expedia.ca/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information) ![6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.](https://images.trvl-media.com/lodging/58000000/57860000/57854500/57854431/90607bc4_y.jpg) ### 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water. 10/10 Excellent "Great house, very spacious, awesome host." [](https://expedia.ca/Anderson-Hotels-Newly-Furnished-And-Renovated-Lake-House-Directly-On-Hartwell.h57854431.Hotel-Information) ![Best Western Seneca-Clemson](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0_y.jpg) ### Best Western Seneca-Clemson 10/10 Excellent "Clean, comfortable room." [](https://expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Everything was clean andwell kept. The supplies for smores and sitting around the fire and wood to burn was great. The picture window in rhe cabin is the best feature of the cabin from the main bed and the bed in the loft. Staff was great." [](https://expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Great place to stay. 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