Title: Book the Best Seneca Adults Only Resorts & Hotels in 2025 from CA $130 | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # Find Adults Only Resorts & Hotels in Seneca, SC from CA $130 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca Adults Only Resorts & Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-15&endDate=2025-10-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seneca Adults Only Resorts & Hotels We don't have any properties that match your exact search [See all properties in Seneca](https://expedia.ca/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=6548&adults=2) ## Recommended hotels in Seneca ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Resort Studio with Kitchen and Two Queen | Private kitchen](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/70e13494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/d191b963.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson Seneca 9.0/10 Wonderful (1015) "Very beautiful place to stay" CA $153 CA $190 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Balcony](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/9fe06894.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/e45ab30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/cc35e730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Seneca Clemson Univ Area Seneca 9.4/10 Exceptional (196) "Nice hotel by the lake" CA $181 CA $199 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/eab53b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/3c50d204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/270-2efd6ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 Downtown 8.0/10 Very good (646) "Staff was friendly very clean " CA $106 CA $130 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/65f927f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/83901eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/a9edd66e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seneca-Clemson Seneca 8.4/10 Very good (620) "Convenient for Clemson visits." CA $125 CA $138 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/313b57b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/877edfc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/52f82f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Seneca-Clemson Area Seneca 9.4/10 Exceptional (647) "Great place to stay" CA $173 CA $190 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/2bb8d81a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible (Hearing, Roll-In Shower)](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/d36e662a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Seneca Clemson Seneca 9.2/10 Wonderful (776) "Clean room, staff was great, will always stay at this hotel in Clemson. Best place to stay!" CA $137 CA $151 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/e0c6bce4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/d703ded8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/7a250fe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/ef541c36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC Seneca 10/10 Exceptional (7) CA $161 CA $290 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Seneca-Hotels-Charming-1-Bedroom-Farmhouse-In-Marvelous-Seneca-With-WiFi.h118111429.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96690000/96683100/96683053/c9400e06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/97000000/96690000/96683100/96683053/783bd314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/97000000/96690000/96683100/96683053/1cece012.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/97000000/96690000/96683100/96683053/e4fb4aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Room #3 Downtown 9.4/10 Exceptional (12) "More like a hotel room which was just perfect for our visit for Clemson graduation" CA $196 CA $310 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Seneca-Hotels-Private-Room-3.h96683053.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96690000/96684200/96684171/e82aa6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/97000000/96690000/96684200/96684171/72eb904e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/97000000/96690000/96684200/96684171/51c2fa13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/97000000/96690000/96684200/96684171/7d406dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique hotel in historic downtown Seneca. Room #5, two King beds. Downtown 9.6/10 Exceptional (13) "Great place to stay in Seneca. Very clean, comfortable beds, great location. Will definitely stay again!" CA $196 CA $310 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Seneca-Hotels-Boutique-Hotel-In-Historic-Downtown-Seneca-Room-5.h96684171.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96690000/96684400/96684378/w1290h856x0y0-36eb931e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/97000000/96690000/96684400/96684378/0ea4c48a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/97000000/96690000/96684400/96684378/94a7d324.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/97000000/96690000/96684400/96684378/230e4003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique hotel in historic downtown Seneca. Room #6, King Bed. Downtown 9.4/10 Exceptional (22) "Great room, very clean and comfortable bed!" CA $182 CA $293 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Seneca-Hotels-Boutique-Hotel-In-Historic-Downtown-Seneca-Room-6.h96684378.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. 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