A calm lake with mountains in the background.

Find Adults Only Resorts & Hotels in Seneca, SC from CA $124

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Seneca Adults Only Resorts & Hotels

Tonight
Sep 12 - Sep 13
Tomorrow
Sep 13 - Sep 14
Next weekend
Sep 18 - Sep 20
In two weeks
Sep 25 - Sep 27
No exact matches found, but these alternatives could be just right

Recommended hotels in Seneca

An outdoor patio area with a fire pit, seating, and string lights.
A food court with a beverage display, seating area, and a Clemson University sign.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern restaurant with a central counter, seating area, and a TV displaying news.

1. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
United States
Curtis
CA $158
CA $173 total
includes taxes & fees
Oct 12 - Oct 13
Tru by Hilton Seneca Clemson
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
United States
kendra
CA $167
CA $184 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn & Suites Seneca-Clemson Area
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

3. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
United States
Robert
CA $105
CA $124 total
includes taxes & fees
Sep 20 - Sep 21
Quality Inn Seneca US-123
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
CA $134
CA $148 total
includes taxes & fees
Sep 15 - Sep 16
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A spacious dining area with a long wooden table and patterned upholstered chairs.
An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
United States
Christopher
CA $151
CA $187 total
includes taxes & fees
Sep 22 - Sep 23
Lakeside Lodge Clemson
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern lobby with a reception desk, seating area, and a vending machine.

6. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
United States
Angela
CA $166
CA $183 total
includes taxes & fees
Sep 27 - Sep 28
Fairfield Inn & Suites Seneca Clemson Univ Area
A modern dining area with a high ceiling, large windows, and a buffet setup.
A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A Days Inn reception area with a view of a parking lot and a grassy area.

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
United States
Rosario
CA $117
CA $128 total
includes taxes & fees
Sep 24 - Sep 25
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a large window, surrounded by trees.
A wooden interior with a table, chair, and a hanging lantern.
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
United States
Nirumol
CA $128
CA $202 total
includes taxes & fees
Sep 27 - Sep 28
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.
A modern living room with a sectional sofa, a coffee table, and a television.
A modern dining area with a large table, wicker chairs, and a television in the background.
A modern living room with a large dining table, white chairs, a sofa, and a television.

9. Boutique hotel in historic downtown Seneca. Room #5, two King beds.

Boutique hotel in historic downtown Seneca. Room #5, two King beds.
Downtown
United States
Joseph K.
CA $175
CA $281 total
includes taxes & fees
Sep 14 - Sep 15
Boutique hotel in historic downtown Seneca. Room #5, two King beds.
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.
A modern dining area with a large table, wicker chairs, and a television in the background.
A modern living room with a large dining table, white chairs, a sofa, and a television.
A hotel room with a tufted headboard, a nightstand with a lamp, and a bed with white bedding and decorative pillows.

10. Private Room #3

Private Room #3
Downtown
United States
Jennifer R.
CA $174
CA $284 total
includes taxes & fees
Sep 23 - Sep 24
Private Room #3
View all properties

Top Seneca Hotel Reviews

Explore a world of travel with Expedia