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Your Santana Vacation

Art, food, entertainment and more … There's so much to experience with a Santana vacation package. And with the ability to easily customize your city adventure, it's guaranteed to be one you won't forget. When it's time to venture out and explore, be sure to put Cathedral of São Tomé and Estadio Nacional 12 de Julho on the to-do list for your trip to Santana. Your ideal Santana vacation is a couple of clicks away. Explore accommodations, flights and more on Expedia for a getaway that's tailored just for you.

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Santana Hotel Deals

Sea House

Santana Cantagalo

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Roça Santo António Ecolodge Hotel

Roça Santo Antonio Santana

8.4/10 Very good! (15 reviews)

"This is a wonderful place to stay. I loved room #1!"

Reviewed on Apr 23, 2022

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Pool and Beach Villa in Santana

Estrada brasil Roca Uba Budo Praia Santana São Tomé

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See all 52 properties in Santana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.