Santa Cruz Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
A barren landscape with red soil and sparse yellow grass, a distant mountain range, and a clear blue sky.

Central North

You'll enjoy the waterfalls and riverfront in Central North. You might want to make time for a stop at Cine Teatro Cuiaba or Republic Square.

Find hotels in Central North

Santa Cruz Hotel Deals

Alugo Apartamento no Centro de Cuiabá

Alugo Apartamento no Centro de Cuiabá

Cuiaba Mato Groso
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Alugo Apartamento no Centro de Cuiabá
Delmond Hotel

Delmond Hotel

4 out of 5
Av. Andre Antonio Maggi, 1980 Cuiabá MT
Fully refundableReserve now, pay when you stay
The price is CA $70 per night from Nov 1 to Nov 2
CA $70
CA $80 total
Nov 1 - Nov 2
includes taxes & fees
9.2/10 Wonderful! (934 reviews)
"Location"

Reviewed on Oct 25, 2026

Delmond Hotel
Amazon Aeroporto Hotel

Amazon Aeroporto Hotel

3 out of 5
Avenida Governador Joao Ponce de Arruda Varzea Grande Mato Grosso
Fully refundableReserve now, pay when you stay
The price is CA $133 per night from Oct 30 to Oct 31
CA $133
CA $153 total
Oct 30 - Oct 31
includes taxes & fees
9.4/10 Exceptional! (899 reviews)
"This hotel is the best airport hotel in Brazil!!! Clean comfortable room, shower, beds, linen, friendly helpful staff, delicious breakfast, great restaurant, very close to the airport (only 5 min by the shuttle bus), very close to the shopping mall. Amazing!!!"

Reviewed on Oct 24, 2026

Amazon Aeroporto Hotel
See all 132 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Santa Cruz vacation package cost?
From just , you can custom build your Santa Cruz vacation package. Simply combine hotels, flights and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Santa Cruz?
It's easy. Just bundle. Flights, hotels and rental cars — combine whatever you need into a Santa Cruz vacation package to save loads of cash. Score even more discounts when you include extras such as day tours to your booking. But that's not the only impressive part. You have the freedom to customize your trip your own way. We offer over 550 air carriers and 1,000,000 hotel options in all corners of the globe, so that everyone has an opportunity to travel and fulfill those vacation fantasies.
Where should I stay in Santa Cruz?
Tick Arena Pantanal off your must-see list and then stay moments from it. Soak up the exciting vibe around this major attraction and visit whenever you like!
How far in advance should I book my Santa Cruz vacation?
Browse Expedia to compare international flights as soon as possible. In many cases, you can purchase a ticket up to a year before departure. If it's too early for your preferred carrier, or you're booking late, don't worry. Cheap tickets to Santa Cruz sometimes appear within weeks of departure.
What does an Expedia Santa Cruz travel package include?
From hotels and airfares to car rentals, Expedia can help you create a Santa Cruz package that's ideal for you. Heading away for a week or longer? Look into a rental car, hotel and flight bundle. If you're taking a short break, an airfare and hotel deal could suit you better. Activities can also be added after you've booked. Our vacation packages make it easy to save and plan.
What should I know before booking a Santa Cruz travel package?
Locking in all the parts of your trip together is an excellent way to save. Bundle your airfares, rental cars and hotels into a tidy package. But hotels aren't your only option. Expedia offers all types of properties, including vacation rentals such as beach villas and city residences. You've got loads of choices!
Can I choose my airline with a Santa Cruz Expedia vacation package?
Definitely. Expedia has over 550 airline partners to pick from around the globe. With such a big range of choice, finding the perfect carrier to fly you to Santa Cruz will be a breeze.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, you can. We totally understand that even the best-laid plans can go awry, so we're here to help if you need to make changes to your Santa Cruz vacation package. You may be able to amend or cancel your itinerary for free if you've booked within 24 hours. Your airline, hotel or car rental company may charge you a fee if you booked more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.

Things to do

8 Days Jaguars and Pantanal Safari tour

8 Days Jaguars and Pantanal Safari tour

CA $7,986
per adult
8 Days Jaguars and Pantanal Safari tour
See all activities in Cuiabá
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.