Title: Book the Best BUSINESS Hotels in Santa Ana in 2026 | Expedia.ca [Santa Ana Travel Guide](https://expedia.ca/Santa-Ana.dx9267)[Hotels in Santa Ana](https://expedia.ca/Santa-Ana-Hotels.d9267.Travel-Guide-Hotels)[Vacation Rentals in Santa Ana](https://expedia.ca/Santa-Ana-Vacation-Rentals.d9267.Travel-Guide-VacationRentals)[Flights to Santa Ana](https://expedia.ca/Cheap-Flights-To-Santa-Ana.d9267.Travel-Guide-Flights)[Things to do in Santa Ana](https://expedia.ca/Things-To-Do-In-Santa-Ana.d9267.Travel-Guide-Activities)[Santa Ana Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Ana.d9267.Car-Rental-Guide)[Santa Ana Vacation Packages](https://expedia.ca/Santa-Ana.d9267.Destination-Travel-Guides) ![Daytime skyline view of downtown Santa Ana, California, USA.](https://images.trvl-media.com/place/9267/e893626d-e496-4018-a142-592df3637ff8.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Santa Ana, CA from CA $139 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Ana Business Hotels Tonight [Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=9267&startDate=2025-12-11&endDate=2025-12-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=9267&startDate=2025-12-12&endDate=2025-12-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=9267&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=9267&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Santa Ana business-friendly hotels ![Property amenity](https://images.trvl-media.com/lodging/13000000/12770000/12765600/12765572/589970fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/13000000/12770000/12765600/12765572/dcbcd7a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12770000/12765600/12765572/28f18455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/13000000/12770000/12765600/12765572/3f63a7f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MainStay Suites John Wayne Airport by Choice Hotels [](https://www.expedia.ca/Santa-Ana-Hotels-Country-Inn-Suites-By-Radisson.h12765572.Hotel-Information) Santa Ana 8.0/10 Very good (1478) "Clean and staff was friendly. Delicious breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martha CA $129 CA $146 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Santa-Ana-Hotels-Country-Inn-Suites-By-Radisson.h12765572.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24100/24076/d20f3331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/30000/24100/24076/41fde104.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24100/24076/7b76b234.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/30000/24100/24076/68d572c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Santa Ana Orange County Airport by IHG [](https://www.expedia.ca/Santa-Ana-Hotels-Holiday-Inn-Santa-Ana-Orange-County-Airport.h24076.Hotel-Information) Santa Ana 8.8/10 Excellent (1121) "Staff was friendly, room was clean, breakfast was fantastic." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carmen CA $148 CA $168 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Santa-Ana-Hotels-Holiday-Inn-Santa-Ana-Orange-County-Airport.h24076.Hotel-Information) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/870000/866100/866005/a168c9b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/870000/866100/866005/88036320.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/870000/866100/866005/w3836h2602x4y4-ba8d518a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/870000/866100/866005/w3836h2602x4y4-c06f5eea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zessa Orange County Airport, a DoubleTree by Hilton [](https://www.expedia.ca/Santa-Ana-Hotels-DoubleTree-By-Hilton-Santa-Ana-Orange-County-Airport.h866005.Hotel-Information) Santa Ana 9.0/10 Wonderful (558) "We had a beautiful stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lawrence CA $135 CA $153 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Santa-Ana-Hotels-DoubleTree-By-Hilton-Santa-Ana-Orange-County-Airport.h866005.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3600/3589/60b3aec6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3600/3589/26891f24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/3600/3589/ee7372c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3600/3589/4e4a688f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Orange County Airport North [](https://www.expedia.ca/Santa-Ana-Hotels-Best-Western-Plus-Orange-County-Airport-North.h3589.Hotel-Information) Santa Ana 8.6/10 Excellent (1696) "It was a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) magali CA $150 CA $170 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Santa-Ana-Hotels-Best-Western-Plus-Orange-County-Airport-North.h3589.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/1000000/20000/19400/19370/41d3179b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19400/19370/a7079a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/20000/19400/19370/7d0b79f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19400/19370/6858ed21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Orange County Airport [](https://www.expedia.ca/Santa-Ana-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Orange-County-Airport.h19370.Hotel-Information) Santa Ana 7.8/10 Good (2009) "My family and I enjoyed our stay. Would book again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Latausha CA $123 CA $139 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Santa-Ana-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Orange-County-Airport.h19370.Hotel-Information) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/20700/20677/031d4d51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/20700/20677/87a9f731.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20700/20677/33b749b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/20700/20677/5ee8d9b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Orange County John Wayne Airport [](https://www.expedia.ca/Santa-Ana-Hotels-Comfort-Inn-Suites-Orange-County-John-Wayne-Airport.h20677.Hotel-Information) Santa Ana 8.0/10 Very good (1003) "Room seemed newly renovated, great access, it was quiet and I would definitely would think about this hotel if staying around the area again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Salvador CA $125 CA $142 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Santa-Ana-Hotels-Comfort-Inn-Suites-Orange-County-John-Wayne-Airport.h20677.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16800/16703/73dfb982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16800/16703/c3f6e906.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/16800/16703/0169c4c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/16800/16703/5829e937.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Santa Ana - Orange County by IHG [](https://www.expedia.ca/Santa-Ana-Hotels-Holiday-Inn-Express-And-Suites-Santa-Ana-Orange-County.h16703.Hotel-Information) Lyon Street 8.6/10 Excellent (1215) "enjoyed our stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $152 CA $172 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Santa-Ana-Hotels-Holiday-Inn-Express-And-Suites-Santa-Ana-Orange-County.h16703.Hotel-Information) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/660000/659900/659899/4528c9de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/660000/659900/659899/14cb9c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/660000/659900/659899/996b0740.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/660000/659900/659899/3459f4b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta Simply Suites Orange County Airport [](https://www.expedia.ca/Santa-Ana-Hotels-Sonesta-Simply-Suites-Orange-County-Airport.h659899.Hotel-Information) Santa Ana 7.4/10 Good (1000) "Conviently located next to John Wayne airport and quiet." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Phong CA $128 CA $145 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Santa-Ana-Hotels-Sonesta-Simply-Suites-Orange-County-Airport.h659899.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/5000000/4280000/4278300/4278264/aa22a2f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/5000000/4280000/4278300/4278264/95d33ea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/5000000/4280000/4278300/4278264/a0b2b495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/5000000/4280000/4278300/4278264/30deb854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Santa Ana Orange County [](https://www.expedia.ca/Santa-Ana-Hotels-Courtyard-By-Marriott-Santa-Ana-Orange-County.h4278264.Hotel-Information) Santa Ana 8.6/10 Excellent (1000) "The staff and hotel were fantastic and it was very quiet during my stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JAMES CA $160 CA $181 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Santa-Ana-Hotels-Courtyard-By-Marriott-Santa-Ana-Orange-County.h4278264.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24900/24833/eacc4b3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24900/24833/62e0407d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24900/24833/dc5f4bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24900/24833/1f3173bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton Santa Ana Orange County Airport [](https://www.expedia.ca/Santa-Ana-Hotels-Embassy-Suites-By-Hilton-Santa-Ana-Orange-County-Airport.h24833.Hotel-Information) Santa Ana 6.2/10 (1752) "Price was good, Location was good, breakfast was excellent for my family of 5 and suite was clean and was spacious for all 5 of us." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Randy CA $143 CA $162 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Santa-Ana-Hotels-Embassy-Suites-By-Hilton-Santa-Ana-Orange-County-Airport.h24833.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-25&endDate=2025-12-26®ionId=9267&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Santa Ana Hotel Reviews ![Howard Johnson by Wyndham Anaheim Hotel & Water Playground](https://images.trvl-media.com/lodging/1000000/20000/19700/19662/645bea3a_y.jpg) ### Howard Johnson by Wyndham Anaheim Hotel & Water Playground 10/10 Excellent "Clean room" [](https://expedia.ca/Anaheim-Hotels-Howard-Johnson-By-Wyndham-Anaheim-Hotel-Water-Playground.h19662.Hotel-Information) ![Fairfield by Marriott Anaheim Resort](https://images.trvl-media.com/lodging/1000000/20000/13800/13771/07236913_y.jpg) ### Fairfield by Marriott Anaheim Resort 10/10 Excellent "room was ready early. Very happy" [](https://expedia.ca/Anaheim-Hotels-Fairfield-By-Marriott-Anaheim-Resort.h13771.Hotel-Information) ![Desert Palms Hotel & Suites](https://images.trvl-media.com/lodging/1000000/10000/1600/1571/94539ef3_y.jpg) ### Desert Palms Hotel & Suites 10/10 Excellent "Walking distance to restaurants and Disneyland " [](https://expedia.ca/Anaheim-Hotels-Desert-Palms-Hotel-Suites.h1571.Hotel-Information) ![Solara Inn and Suites](https://images.trvl-media.com/lodging/1000000/10000/9200/9123/c3523dd3_y.jpg) ### Solara Inn and Suites 10/10 Excellent "Staff was great! Beds were comfortable. " [](https://expedia.ca/Anaheim-Hotels-Solara-Inn-And-Suites.h9123.Hotel-Information) ![Anaheim Majestic Garden Hotel](https://images.trvl-media.com/lodging/1000000/30000/24200/24131/b67790ff_y.jpg) ### Anaheim Majestic Garden Hotel 10/10 Excellent "Staff was great. Room was great. My girst time staying there and plan on returning " [](https://expedia.ca/Anaheim-Hotels-Anaheim-Majestic-Garden-Hotel.h24131.Hotel-Information) ![Grand Legacy At the Park](https://images.trvl-media.com/lodging/14000000/13070000/13060100/13060062/9da742e7_y.jpg) ### Grand Legacy At the Park 10/10 Excellent "Great location." [](https://expedia.ca/Anaheim-Hotels-Grand-Legacy-At-The-Park.h13060062.Hotel-Information) ![Hotel Lulu, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/30000/21000/20965/cc6bb6ca_y.jpg) ### Hotel Lulu, BW Premier Collection 10/10 Excellent "Great stay at Hotel Lulu" [](https://expedia.ca/Anaheim-Hotels-Hotel-Lulu.h20965.Hotel-Information) ![Kings Inn Anaheim at the Park & Convention Center](https://images.trvl-media.com/lodging/1000000/20000/19000/18921/cbed5bab_y.jpg) ### Kings Inn Anaheim at the Park & Convention Center 10/10 Excellent "Yrs very awesome experience Looking forward for next year " [](https://expedia.ca/Anaheim-Hotels-Kings-Inn-Anaheim-At-The-Park-Convention-Center.h18921.Hotel-Information) ![Anaheim Marriott Hotel](https://images.trvl-media.com/lodging/1000000/20000/12100/12035/ae5c023a_y.jpg) ### Anaheim Marriott Hotel 10/10 Excellent "Great staff!" [](https://expedia.ca/Anaheim-Hotels-Anaheim-Marriott-Hotel.h12035.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Santa Ana cost? ### What are the best business-friendly hotels in Santa Ana? ### How many business-friendly hotels are there in Santa Ana? ### What are the best cheap business-friendly hotels in Santa Ana? ### What are the top business-friendly motels in Santa Ana? ### Are there any family-friendly hotels in Santa Ana that are also business friendly? ### Are there any 5-star business-friendly hotels in Santa Ana? ### Why book your business-friendly hotel in Santa Ana with Expedia? ### How can I find cheap business-friendly hotels in Santa Ana? ### What is there to do in Santa Ana near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [All Inclusive Resorts and in Anaheim Hills ](https://www.expedia.ca/Anaheim-Hills-Anaheim-Hotels-All-Inclusive-Hotel.0-n184243-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - 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