Roxana Vacation Packages

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    Save up to CA $1,096 when you book a flight and hotel together*
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Your Roxana Vacation

Let our vacation packages to Roxana inspire your next escape. There's tons to love about this exciting city, starting with the neighborhood of Old Jamestown, which is great for nature and walking. Fill your free time with tours of Fast Eddies Bon Air, Robert Wadlow Statue and Lewis and Clark Interpretive Center, some of the top attractions you should see during your trip to Roxana. Your dream Roxana vacation is a few clicks away. Search hotels, airfares and more on Expedia for a getaway that's tailored to suit your travel style.

Top Roxana Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo St Louis - Central West End by IHG
The Wildwood Hotel
Hotel Saint Louis, Autograph Collection
Hilton Garden Inn St. Louis/O'Fallon MO
The Knight Center at Washington University

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Roxana Hotel Deals

21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is CA $182 per night from Feb 22 to Feb 23
CA $182
CA $219 total
Feb 22 - Feb 23
includes taxes & fees
9/10 Wonderful! (1,594 reviews)
Everything was great i can’t wait to stay again

Reviewed on Feb 6, 2026

21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
The price is CA $143 per night from Feb 26 to Feb 27
CA $143
CA $167 total
Feb 26 - Feb 27
includes taxes & fees
8.8/10 Excellent! (3,083 reviews)
Cleanliness, staff nice

Reviewed on Feb 7, 2026

Clayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
The price is CA $122 per night from Feb 16 to Feb 17
CA $122
CA $144 total
Feb 16 - Feb 17
includes taxes & fees
9.2/10 Wonderful! (2,806 reviews)
Clean rooms, comfy beds and convenient shuttle to the airport. The breakfast was good with plenty of options (both hot and cold) and plenty of food. The staff was very friendly and helpful.

Reviewed on Feb 4, 2026

Pear Tree Inn St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.