A pier extending into calm waters with a small boat docked at the end.

Panacea Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Panacea vacation rentals

1. Panacea Treehouse⭐️ Quiet Waterfront - Boat Friendly Old Florida Experience

Panacea Treehouse⭐️ Quiet Waterfront - Boat Friendly Old Florida Experience
Panacea
10.0 out of 10, Exceptional, (25 reviews)
"Great place to stay while fishing"
United States
Benjamin S.
The price is CA $198
CA $459 total
includes taxes & fees
Sep 24 - Sep 25
Panacea Treehouse⭐️ Quiet Waterfront - Boat Friendly Old Florida Experience

2. romantic get away for 2 right on the Ochlockonee river

romantic get away for 2 right on the Ochlockonee river
Panacea
6.0 out of 10, (2 reviews)
"Wonderful accommodations-clean and comfortable. "
United States
Laurie K.
The price is CA $183
CA $440 total
includes taxes & fees
Oct 6 - Oct 7
romantic get away for 2 right on the Ochlockonee river

3. Tiny Tides Waterfront Cottage

Tiny Tides Waterfront Cottage
Panacea
10.0 out of 10, Exceptional, (12 reviews)
"What a perfect escape! We thoroughly enjoyed our stay at Tiny Tides. The cozy, comfortable vibe, the peaceful location, and the easy access to everything made our trip truly special. We had a fantastic time and will definitely be back soon!"
United States
Jason W.
The price is CA $260
CA $559 total
includes taxes & fees
Sep 27 - Sep 28
Tiny Tides Waterfront Cottage

4. Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock
Panacea
9.6 out of 10, Exceptional, (106 reviews)
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

5. Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks

Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks
Panacea
10.0 out of 10, Exceptional, (5 reviews)
"Wonderful view and beautiful home. Enjoyed making memories at this place"
United States
Toby H.
The price is CA $282
CA $682 total
includes taxes & fees
Oct 5 - Oct 6
Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks

6. Queen Kitchenette by the Bay #16

Queen Kitchenette by the Bay #16
Panacea
10.0 out of 10, Exceptional, (1 review)
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #16

7. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Cozy Panacea Retreat #3 (King)

8. Perfect Panacea 1 Bedroom Apt, #2

Perfect Panacea 1 Bedroom Apt, #2
Panacea
The price is CA $199
CA $236 total
includes taxes & fees
Sep 27 - Sep 28
Perfect Panacea 1 Bedroom Apt, #2

9. 09) Queen Kitchenette by the Bay

09) Queen Kitchenette by the Bay
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
09) Queen Kitchenette by the Bay

10. Queen Kitchenette by the Bay #15

Queen Kitchenette by the Bay #15
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #15

11. Queen Kitchenette by the Bay #11

Queen Kitchenette by the Bay #11
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #11

12. Queen Kitchenette by the Bay #14

Queen Kitchenette by the Bay #14
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #14

13. Queen Kitchenette by the Bay #10

Queen Kitchenette by the Bay #10
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #10

14. Queen Kitchenette by the Bay #13

Queen Kitchenette by the Bay #13
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #13

15. Cozy Panacea Retreat #7 (King)

Cozy Panacea Retreat #7 (King)
Panacea
The price is CA $199
CA $250 total
includes taxes & fees
Oct 6 - Oct 7
Cozy Panacea Retreat #7 (King)

16. Point & Paddle Waterfront Retreat @Alligator Point

Point & Paddle Waterfront Retreat @Alligator Point
Alligator Point
10.0 out of 10, Exceptional, (2 reviews)
"We really enjoyed the place. It was quiet, cozy, and perfect for a quick getaway with our family. I would highly recommend others checking this place out and tho we don’t visit the area much we would love staying here again!"
United States
Scott A.
The price is CA $267
CA $683 total
includes taxes & fees
Sep 29 - Sep 30
Point & Paddle Waterfront Retreat @Alligator Point

17. Panacea Cozy Retreat #6 (DQ)

Panacea Cozy Retreat #6 (DQ)
Panacea
The price is CA $248
CA $311 total
includes taxes & fees
Oct 6 - Oct 7
Panacea Cozy Retreat #6 (DQ)

18. Panacea Cozy Retreat #4 (DQ)

Panacea Cozy Retreat #4 (DQ)
Panacea
The price is CA $248
CA $311 total
includes taxes & fees
Oct 6 - Oct 7
Panacea Cozy Retreat #4 (DQ)

19. Queen Kitchenette by the Bay #8

Queen Kitchenette by the Bay #8
Panacea
The price is CA $247
CA $309 total
includes taxes & fees
Oct 6 - Oct 7
Queen Kitchenette by the Bay #8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Panacea Hotel Reviews

Find out more about Panacea

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Panacea. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Panacea?

Yes, there are vacation rentals in Panacea close to Gulf Specimen Public Aquarum, or you can go with a secluded option if you'd like a relaxing place to stay. Visitors to Panacea speak positively about the beaches and seafood restaurants in this destination.

What are some of the best vacation rentals in Panacea?

BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has an outdoor pool, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. Some other homes for rent in Panacea include Coastal Getaway on canal-steps to the beach and Your Fall Escape: FSU Football & Scalloping.

How many vacation rentals are there in Panacea?

Choose from 178 Expedia vacation rentals in Panacea for a memorable vacation.

What’s there to see and do in Panacea?

Mashes Sand Beach and Alligator Point Beach are a couple of lovely local spots to enjoy the outdoors, whereas family-friendly attractions include Gulf Specimen Public Aquarum. While here, Bald Point State Park and Wilson Beach are other places worth a visit.

What’s a vacation rental in Panacea like?

Vacation rentals are privately owned properties where you can stay for a few weeks or just a few days in Panacea. Vacation rentals offer amenities like laundry facilities and kitchens so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of seclusion away from shared hotel elevators and busy reception areas while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental a popular choice for family trips or small group gatherings.