Panacea Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

Photo by Barbara Brogdon

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    Save up to CA $1,096 when you book a flight and hotel together*
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Your Panacea Vacation

When you book a vacation package to Panacea, you can relax and enjoy your getaway knowing that all your travel plans have been worked out ahead of time. Discover the wonders of this city while based in a neighborhood like Ochlockonee Bay, which is great for nature. Up for some sightseeing? A trip to Panacea isn't complete without visiting Mashes Sand Beach, Ochlockonee River State Park and other popular attractions. Check out Expedia's wide range of travel options and start organizing your ideal vacation to Panacea now.

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Panacea Hotel Deals

The Panacea Motel
The Panacea Motel
2 out of 5
1545 Coastal Hwy, Panacea, FL
The price is CA $146 per night from Jul 13 to Jul 14
CA $146
CA $163 total
Jul 13 - Jul 14
includes taxes & fees
9/10 Wonderful! (102 reviews)
Great rooms and location
"Very cute retro motel on the bay and walking distance to restaurants and bars. Also had use of a golf cart. Will definitely be back."

Reviewed on Jul. 6, 2025

The Panacea Motel
Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.
Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.
Alligator Point
9.8/10 Exceptional! (29 reviews)
Another great visit
"My family has stayed at Tiki House twice and it has been great both visits. Good location, right on the beach and hosts are great. We plan to visit again next year."

Reviewed on Jun. 28, 2025

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Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.
Secluded Florida Beach Bungalow SPECIAL!!! 10% OFF ANYTIME JUNE 6-JUNE 13TH
Secluded Florida Beach Bungalow SPECIAL!!! 10% OFF ANYTIME JUNE 6-JUNE 13TH
Panacea, FL
9.8/10 Exceptional! (219 reviews)
10/10 review
"Beautiful little treasure of a house, great location -very short walk to what feels like your own private beach. wonderful Owner/Manager (Sheree) We will be back!"

Reviewed on Jul. 6, 2025

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Secluded Florida Beach Bungalow SPECIAL!!! 10% OFF ANYTIME JUNE 6-JUNE 13TH
See all 494 properties in Panacea
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Family Vacations

Family Vacations

Discover the most popular places to visit in Panacea

USS Mohawk CGC Veterans Memorial Reef

You can find out about the history of Panacea with a visit to USS Mohawk CGC Veterans Memorial Reef. Wander around the natural setting in this relaxing area, or simply enjoy its seafood restaurants.

USS Mohawk CGC Veterans Memorial Reef

Frequently asked questions

How much does a Panacea vacation package cost?
You can grab a vacation package to this popular destination on Expedia. But how much your vacation to Panacea costs will depend on the length of stay, season and hotel choice.
What are the cheapest months to go to Panacea?
December, January and February are the best times to search for cheap Panacea vacation packages. Travelling in less busy months means you can typically find reduced prices on hotels and flights.
How many days is enough for Panacea?
The ideal duration of your Panacea vacation depends on what you'd like to do and see. Usually, a handful of days to a week will give you enough time to hit all the main sights and discover some hidden spots along the way.
How to find the best Panacea package deals?
Bagging a cheap Panacea package deal is a cinch with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can fine-tune your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Panacea package deals. Want a simple trick to get the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are typically lower.
Is it cheaper to book a Panacea vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, hotel and car rental into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component individually. And you'll still enjoy the flexibility to create a tailored Panacea vacation by choosing your preferred accommodation type, airline and car class.
When to book a vacation package to Panacea?
If you have your Panacea travel dates finalized, book as soon as you can to grab some unbeatable deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment trips? Our last-minute deals are ideal for jetting off on a whim.
How to plan a trip to Panacea?

  1. Choose your dates: What you plan to do in Panacea and your preferred season will help you decide when to travel.
  2. Work out your budget: Ensure you have enough money to pay for everything from transportation and dining out to airfares and activities. Your hotel will probably be the biggest expense during your trip to Panacea.
  3. Set the duration of your trip: Start by listing all the activities and attractions you want to experience in Panacea. Then, estimate how long you'll need at each, including any travel time.
  4. Bundle your bookings: With your travel dates in order, you can combine your hotels, flights, car rental and more into a tailored Panacea vacation package.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.