Panacea Vacation Rentals

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Check prices for these dates

Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29
In one month
Dec 11 - Dec 13
In two months
Jan 8 - Jan 10

Our top choices for Panacea vacation homes

A modern kitchen with a wooden countertop, a built-in sink, and a dining area with a table and chairs.

1. Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat

Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat
Panacea
9.8 out of 10, Exceptional, (28 reviews)
"Great place to stay while fishing"
United States
Benjamin S.
The price is CA $185
CA $429 total
includes taxes & fees
Nov 16 - Nov 17
Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat
A covered outdoor area with a wooden deck, white furniture, and a view of the water.

2. Tiny Tides Waterfront Cottage

Tiny Tides Waterfront Cottage
Panacea
10.0 out of 10, Exceptional, (15 reviews)
"What a perfect escape! We thoroughly enjoyed our stay at Tiny Tides. The cozy, comfortable vibe, the peaceful location, and the easy access to everything made our trip truly special. We had a fantastic time and will definitely be back soon!"
United States
Jason W.
The price is CA $225
CA $539 total
includes taxes & fees
Nov 18 - Nov 19
Tiny Tides Waterfront Cottage
A dock extending into a body of water with a covered structure at the end.

3. Private beach winter escape on the bay with fishing and kayaks

Private beach winter escape on the bay with fishing and kayaks
Panacea
10.0 out of 10, Exceptional, (5 reviews)
"Had a great stay! We would book here again."
United States
Ashley D.
The price is CA $287
CA $661 total
includes taxes & fees
Nov 15 - Nov 16
Private beach winter escape on the bay with fishing and kayaks
A porch with wicker chairs and a small table, overlooking a lake and trees.

4. Point & Paddle Waterfront Retreat @Alligator Point

Point & Paddle Waterfront Retreat @Alligator Point
Alligator Point
10.0 out of 10, Exceptional, (2 reviews)
"We really enjoyed the place. It was quiet, cozy, and perfect for a quick getaway with our family. I would highly recommend others checking this place out and tho we don’t visit the area much we would love staying here again!"
United States
Scott A.
The price is CA $271
CA $634 total
includes taxes & fees
Nov 15 - Nov 16
Point & Paddle Waterfront Retreat @Alligator Point
A wooden deck with wicker chairs and a long table, overlooking a beach and ocean.

5. The Best Beach-Front House “Get-A-Way” in Florida

The Best Beach-Front House “Get-A-Way” in Florida
Panacea
10.0 out of 10, Exceptional, (101 reviews)
"Wonderful place on the beach. My sister and I had a great time here. I especially love that the beach is dog-friendly!"
United States
Lisa R.
The price is CA $410
CA $912 total
includes taxes & fees
Nov 14 - Nov 15
The Best Beach-Front House “Get-A-Way” in Florida
A wooden boardwalk surrounded by lush green vegetation and tall trees.

6. Breezy Home w/ Grills, Pool & Beach Access!

Breezy Home w/ Grills, Pool & Beach Access!
Sopchoppy
10.0 out of 10, Exceptional, (28 reviews)
"Great property. House was very clean and well stocked. Neighborhood was very quiet and peaceful. Enjoyed our stay and would love to stay again. "
United States
Lisa M.
The price is CA $312
CA $787 total
includes taxes & fees
Nov 24 - Nov 25
Breezy Home w/ Grills, Pool & Beach Access!
A covered outdoor area with a wooden deck leading to a dock over water, surrounded by large windows.

7. Dock, Boat Lift & Golf Cart on Alligator Point

Dock, Boat Lift & Golf Cart on Alligator Point
Alligator Point
10.0 out of 10, Exceptional, (2 reviews)
"Lovely place! Interesting area and wished we had more time there."
United States
Ann G.
The price is CA $473
CA $1,068 total
includes taxes & fees
Nov 28 - Nov 29
Dock, Boat Lift & Golf Cart on Alligator Point
A wooden deck with outdoor furniture, overlooking a beach and ocean.

8. BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.

BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.
Panacea
9.6 out of 10, Exceptional, (95 reviews)
"Charming beach house just steps away from the beach. The beach was quiet which is a great alternative to crowded beaches. Robin was very responsive and helpful. Would love to come back!"
United States
cyle w.
The price is CA $511
CA $1,126 total
includes taxes & fees
Nov 23 - Nov 24
BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.
A two-story house with a balcony on each floor, a front porch with steps, and a clear sky.

9. NEW - St. Teresa Beach Escape w/ Private Beach Acc

NEW - St. Teresa Beach Escape w/ Private Beach Acc
Lanark Village
10.0 out of 10, Exceptional, (2 reviews)
"This house was very comfortable, beds, pillows, towels, sofa, etc. Quiet, peaceful, serene setting. Close proximity to beach and the pool was an added bonus!Thank you for a very enjoyable stay!"
United States
Debra M.
The price is CA $447
CA $1,127 total
includes taxes & fees
Nov 25 - Nov 26
NEW - St. Teresa Beach Escape w/ Private Beach Acc
A beach with clear water, white sand, and a boat in the distance.

10. 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Alligator Point
10.0 out of 10, Exceptional, (131 reviews)
"The house was perfect for our family, especially my mom who has trouble walking. The elevator worked perfectly, the boardwalk was short and close to the ocean. She and my dad loved sitting on the deck and watching us all on the beach. Communication was great, including updates on the tropical storm. We would definitely recommend this rental. We hope to stay again!"
United States
Lori M.
The price is CA $1,283
CA $3,199 total
includes taxes & fees
Nov 16 - Nov 17
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
A riverside view from a covered deck with wooden docks and a bench.

11. Waterfront -Beautiful sunsets, great fishing, scalloping & bird watching

Waterfront -Beautiful sunsets, great fishing, scalloping & bird watching
Crawfordville
10.0 out of 10, Exceptional, (58 reviews)
"Nice and relaxing"
United States
chad c.
The price is CA $250
CA $395 total
includes taxes & fees
Nov 15 - Nov 16
Waterfront -Beautiful sunsets, great fishing, scalloping & bird watching
An aerial view of a beach with a parking lot, beach umbrellas, and a clear view of the ocean.

12. Dragonfly on the Canal Golf cart included!

Dragonfly on the Canal Golf cart included!
Crawfordville
10.0 out of 10, Exceptional, (65 reviews)
"Very welcoming community and lived up to its name with being fully dragonfly & beach themed. Wish we could have fully enjoyed the outside amenities, but the weather had other plans."
United States
Allison
The price is CA $207
CA $463 total
includes taxes & fees
Nov 16 - Nov 17
Dragonfly on the Canal Golf cart included!
A bedroom with a chandelier, a bed, a dresser, a chair, and a desk.

13. Wedding & Event Residence Sopchoppy 5 bedrooms/Honeymoon Suite

Wedding & Event Residence Sopchoppy 5 bedrooms/Honeymoon Suite
Sopchoppy
The price is CA $7,054
CA $8,113 total
includes taxes & fees
Nov 17 - Nov 18
Wedding & Event Residence Sopchoppy 5 bedrooms/Honeymoon Suite
A bedroom with a bed, a ceiling fan, a nightstand with a lamp, and a window with curtains.

14. The Oyster Bed- Riverwalk Cottages Unit 204 B

The Oyster Bed- Riverwalk Cottages Unit 204 B
Carrabelle
9.8 out of 10, Exceptional, (51 reviews)
"Loved that the property was pet friendly! Enjoyed the stay here as it is close proximity to shopping,dining and sight-seeing!"
United States
Tom K.
The price is CA $164
CA $321 total
includes taxes & fees
Nov 16 - Nov 17
The Oyster Bed- Riverwalk Cottages Unit 204 B
A living room with a glass-top table surrounded by wicker chairs, a black sofa, and a coffee table with decorative items.

15. The Sand Dollar - Riverwalk Cottages Unit 204 A

The Sand Dollar - Riverwalk Cottages Unit 204 A
Carrabelle
10.0 out of 10, Exceptional, (31 reviews)
"Great location, clean cute cottage. Very comfortable."
United States
Debi P.
The price is CA $164
CA $321 total
includes taxes & fees
Nov 16 - Nov 17
The Sand Dollar - Riverwalk Cottages Unit 204 A
A living room with two grey armchairs, a teal cabinet, a glass coffee table with wooden legs, and a flat-screen TV on the wall.

16. FISHERMAN'S PARADISE!! Cozy home 2 minutes to the Gulf

FISHERMAN'S PARADISE!! Cozy home 2 minutes to the Gulf
Carrabelle
9.4 out of 10, Exceptional, (3 reviews)
"Everything was as described. We had a great stay."
United States
Jared R.
The price is CA $371
CA $612 total
includes taxes & fees
Nov 14 - Nov 15
FISHERMAN'S PARADISE!! Cozy home 2 minutes to the Gulf
A two-story house with a covered porch, a staircase, and a view of the surrounding greenery.

17. Beach/Marina/Walking trails and more…

Beach/Marina/Walking trails and more…
Carrabelle
10.0 out of 10, Exceptional, (4 reviews)
"Nice house, pet friendly, easy parking highly recommend. Thanks for a great vacation!"
United States
Edward H.
The price is CA $193
CA $654 total
includes taxes & fees
Nov 14 - Nov 15
Beach/Marina/Walking trails and more…
A hotel room with a bed, a sofa, a dining area with wicker chairs, and a glass table.

18. The Blue Crab at Riverwalk Cottages Unit 202B

The Blue Crab at Riverwalk Cottages Unit 202B
Carrabelle
9.6 out of 10, Exceptional, (15 reviews)
"We enjoyed staying here."
United States
Tammy P.
The price is CA $164
CA $321 total
includes taxes & fees
Nov 14 - Nov 15
The Blue Crab at Riverwalk Cottages Unit 202B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

See all hotels in Panacea
A coastal resort with beachfront villas and a clear blue sky.

Top reviews in Panacea

A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.
Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville

10/10 Excellent

Clean room, good choice in the middle of nowhere
Canada
Detlev
Reviewed January 11, 2026
Best Western Wakulla Inn & Suites

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