Title: Book the Best Palmyra SPA Resorts from CA $145 - Spa Hotels in Palmyra, MO | Expedia.ca [Palmyra Travel Guide](https://expedia.ca/Palmyra.dx183484)[Hotels in Palmyra](https://expedia.ca/Palmyra-Hotels.d183484.Travel-Guide-Hotels)[Vacation Rentals in Palmyra](https://expedia.ca/Palmyra-Vacation-Rentals.d183484.Travel-Guide-VacationRentals)[Palmyra Car Rentals](https://expedia.ca/Car-Rentals-In-Palmyra.d183484.Car-Rental-Guide)[Palmyra Vacation Packages](https://expedia.ca/Palmyra.d183484.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Palmyra, MO from CA $145 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Palmyra Spa Hotels Tonight [Oct 27 - Oct 28](https://www.expedia.ca/Hotel-Search?regionId=183484&startDate=2025-10-27&endDate=2025-10-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=183484&startDate=2025-10-28&endDate=2025-10-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=183484&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=183484&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Palmyra Spa Hotels ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/e4d50f81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/2719bcec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/a188d547.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/3ec3fc7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites - Hannibal Hannibal 7.6/10 Good (644) "The beds were super comfy" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jayme CA $126 CA $145 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Hannibal-Hotels-Comfort-Inn-Suites-Hannibal.h64231.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790802/b191f370.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790802/cd321d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790802/608e58b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790802/c51e10ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Quincy East by IHG Quincy 8.8/10 Excellent (596) "The staff was very nice and helpful. The restaurant was very good and their staff was also great. The rooms were very comfortable and spotless. I wouldn't hesitate to stay hete again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JOANNA CA $178 CA $202 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Quincy-Hotels-Holiday-Inn-Quincy-East.h1790802.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-11&endDate=2025-11-12®ionId=183484&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Palmyra Hotel Reviews ![Stoney Creek Inn Quincy](//images.trvl-media.com/lodging/2000000/1150000/1145000/1144935/89328cf1_y.jpg) ### Stoney Creek Inn Quincy 10/10 Excellent "We had a very good experience." [](https://expedia.ca/Quincy-Hotels-Stoney-Creek-Inn-Quincy.h1144935.Hotel-Information) ![Quality Inn & Suites Hannibal](//images.trvl-media.com/lodging/1000000/990000/983700/983646/13b9e861_y.jpg) ### Quality Inn & Suites Hannibal 10/10 Excellent "Great staff. Property a bit outdated. Noise from person walking in room upstairs (older construction). " [](https://expedia.ca/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information) ![Microtel Inn & Suites by Wyndham Quincy Downtown/River Area](//images.trvl-media.com/lodging/1000000/10000/2900/2890/79b50c7b_y.jpg) ### Microtel Inn & Suites by Wyndham Quincy Downtown/River Area 10/10 Excellent "Big rooms with nice view .pool a little to hot but nice pool" [](https://expedia.ca/Quincy-Hotels-Microtel-Inn-Suites-By-Wyndham-Quincy.h2890.Hotel-Information) ![Best Western On The River](//images.trvl-media.com/lodging/1000000/20000/16300/16249/b520e740_y.jpg) ### Best Western On The River 10/10 Excellent "The room was very comfortable." [](https://expedia.ca/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information) ![Oak Hill Inn & Suites](//images.trvl-media.com/lodging/1000000/910000/904200/904104/9ee5d42b_y.jpg) ### Oak Hill Inn & Suites 10/10 Excellent "Tina the GM was very friendly & helpful throughout our trip along with the rest of staff! Thanks again, Eben" [](https://expedia.ca/Canton-Hotels-Oak-Hill-Inn-Suites.h904104.Hotel-Information) ![Baymont by Wyndham Hannibal](//images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/69dacd1b_y.jpg) ### Baymont by Wyndham Hannibal 10/10 Excellent " There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. " [](https://expedia.ca/Hannibal-Hotels-Hannibal-Inn.h3790159.Hotel-Information) ![AmericInn by Wyndham Quincy](//images.trvl-media.com/lodging/1000000/20000/13500/13454/67443ff2_y.jpg) ### AmericInn by Wyndham Quincy 10/10 Excellent "Everything was great " [](https://expedia.ca/Quincy-Hotels-Comfort-Inn.h13454.Hotel-Information) ![Quality Inn & Suites Quincy - Downtown](//images.trvl-media.com/lodging/1000000/330000/328200/328165/cf8401d3_y.jpg) ### Quality Inn & Suites Quincy - Downtown 10/10 Excellent "Wonderful stay! Front desk staff was friendly and prompt in checking in. Clean, updated room with comfortable bed (on the harder side if that is a concern). Loved having the space and a couch to sit on. My only one complaint (and this is not a slight to the staff) is that breakfast was somewhat depleted as some sports teams were staying there and seemed to have come through right as I was going to breakfast. Perhaps a friendly note to staff to proactively stock breakfast and refills in this case. Otherwise a wonderful stay and will definitely be back!" [](https://expedia.ca/Quincy-Hotels-Quality-Inn-Suites-Quincy-Downtown.h328165.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Palmyra? > Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the museums and coffeehouses in Palmyra—your day trip starts here. Spa hotels are the perfect way to break out of your daily routine and add a layer of luxury to your vacation. ### What's there to see and do in Palmyra? > Enjoy all that Palmyra has to offer and visit Mississippi River, Gardner House Museum, and Dr. J.W. Well Nature Park. If you have a little extra time during your trip, you might want to check out Flower City Park and Bay Island. ### What is a Palmyra spa hotel? > Spa hotels in Palmyra feature on-site spas and offer services like couples massages and a selection of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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