Find Spa Hotels in Odessa, FL from CA $158

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Our top choices for Odessa hotels with a spa

1. Innisbrook Resort

Innisbrook Resort
3.5 star property
Palm Harbor
8.4 out of 10, Very good, (1,000 reviews)
  • cleanliness
    Escape to a resort sanctuary with 12 treatment rooms, tranquil gardens, and 6 outdoor pools where spa indulgence meets golf getaways.
The price is CA $195
CA $293 total
includes taxes & fees
Dec 9 - Dec 10
Innisbrook Resort

2. Saddlebrook Resort

Saddlebrook Resort
4.0 star property
Wesley Chapel South
8.2 out of 10, Very good, (200 reviews)
  • cleanliness
    Rejuvenate your spirit at this premier golf resort with 12 treatment rooms and soothing sauna facilities for total wellness.
The price is CA $173
CA $238 total
includes taxes & fees
Nov 24 - Nov 25
Saddlebrook Resort

3. Safety Harbor Resort & Spa Trademark Collection by Wyndham

Safety Harbor Resort & Spa Trademark Collection by Wyndham
3.0 star property
Safety Harbor
8.4 out of 10, Very good, (1,001 reviews)
  • cleanliness
    Luxuriate in a waterfront wellness haven with 15 treatment rooms, hot mineral springs, and serene pools for a rejuvenating spa retreat.
The price is CA $209
CA $278 total
includes taxes & fees
Nov 16 - Nov 17
Safety Harbor Resort & Spa Trademark Collection by Wyndham

4. Sleep Inn & Suites Tampa South

Sleep Inn & Suites Tampa South
2.5 star property
Sun Bay South
9.0 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Pamper yourself at this Tampa hotel with a full-service spa, outdoor pool, and hot tub, all conveniently located near Tampa Riverwalk.
The price is CA $158
CA $180 total
includes taxes & fees
Nov 17 - Nov 18
Sleep Inn & Suites Tampa South

5. The Grant Street Inn Dunedin Downtown Historic District, an Ascend Collection Hotel

The Grant Street Inn Dunedin Downtown Historic District, an Ascend Collection Hotel
2.5 star property
Downtown Dunedin
9.4 out of 10, Exceptional, (352 reviews)
  • cleanliness
    Immerse in coastal wellness at this spa hotel with outdoor pool and balconies overlooking downtown Dunedin.
The price is CA $201
CA $227 total
includes taxes & fees
Nov 29 - Nov 30
The Grant Street Inn Dunedin Downtown Historic District, an Ascend Collection Hotel

6. Seminole Hard Rock Hotel & Casino Tampa

Seminole Hard Rock Hotel & Casino Tampa
4.0 star property
Tampa
8.8 out of 10, Excellent, (1,381 reviews)
  • cleanliness
    Luxurious spa retreat with 13 treatment rooms and three outdoor pools offers ultimate relaxation getaway.
The price is CA $403
CA $497 total
includes taxes & fees
Nov 23 - Nov 24
Seminole Hard Rock Hotel & Casino Tampa

7. Epicurean Hotel, Autograph Collection

Epicurean Hotel, Autograph Collection
4.0 star property
Hyde Park
9.4 out of 10, Exceptional, (829 reviews)
  • cleanliness
    Discover the ultimate pampering oasis at this hotel with a full-service spa, rooftop garden, and outdoor pool for a rejuvenating escape.
The price is CA $301
CA $344 total
includes taxes & fees
Nov 23 - Nov 24
Epicurean Hotel, Autograph Collection

8. Hilton Clearwater Beach Resort & Spa

Hilton Clearwater Beach Resort & Spa
4.0 star property
Clearwater Beach
8.2 out of 10, Very good, (3,114 reviews)
  • cleanliness
    Indulge in restorative treatments at this waterfront sanctuary with 7 spa rooms and beachfront yoga sessions.
The price is CA $254
CA $342 total
includes taxes & fees
Nov 19 - Nov 20
Hilton Clearwater Beach Resort & Spa

9. Wyndham Grand Clearwater Beach

Wyndham Grand Clearwater Beach
4.0 star property
Clearwater Beach
9.4 out of 10, Exceptional, (4,052 reviews)
  • cleanliness
    Escape to this beachfront spa sanctuary with 4 treatment rooms, steam room, and private couples massages.
The price is CA $322
CA $420 total
includes taxes & fees
Nov 26 - Nov 27
Wyndham Grand Clearwater Beach

10. Hyatt Regency Clearwater Beach Resort and Suites

Hyatt Regency Clearwater Beach Resort and Suites
4.0 star property
Clearwater Beach
9.4 out of 10, Exceptional, (2,488 reviews)
  • cleanliness
    Seaside spa sanctuary offers couples' massages and hot stone treatments in 8 serene rooms.
The price is CA $318
CA $416 total
includes taxes & fees
Nov 12 - Nov 13
Hyatt Regency Clearwater Beach Resort and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Odessa

Top Odessa Hotel Reviews

Find out more about Odessa

Top Odessa attractions for a relaxing vacation

Odessa, Florida, offers a tranquil escape for travellers seeking spa hotels with access to rejuvenating experiences. Begin your day at the picturesque Lake Elda, where you can enjoy a peaceful morning walk or a family-friendly picnic amidst the scenic surroundings. For those looking to unwind, the nearby Serenity Spa provides a range of treatments, from massages to facials, ensuring you leave feeling refreshed. Explore the lush trails of the J.B. Starkey Wilderness Park, perfect for both hiking and cycling, where you can connect with nature and breathe in the fresh air. After a day of adventure, indulge in gourmet dining at local restaurants like the popular Tarpon Springs Sponge Docks, offering fresh seafood and a taste of authentic Florida. Consider staying in the charming, boutique-style hotels in the area that not only provide luxurious amenities but also personalised service to enhance your experience. With the perfect blend of relaxation and exploration, Odessa invites you to create unforgettable memories.

Frequently Asked Questions

How much does a spa hotel in Odessa cost?

Enjoy staying in a spa hotel in Odessa, with plenty of hotels from CA $158 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, and may vary depending on the location, season, and hotel amenities. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a trip during the weekend or around public holidays.

Is it cheaper to book a spa hotel in Odessa with flights as part of a package deal?

Booking a hotel and flight package on Expedia can be cheaper than booking flights and hotels separately. Bundling can lead to significant savings, especially for international travel or when booking well in advance. However, savings vary depending on factors like destination, travel dates, and availability, so it’s wise to compare options. With access to over 300,000 hotels worldwide, Expedia makes it easy to build the perfect travel package.

Are there any unique spa experiences available in Odessa?

Yes, Odessa, Florida, offers several unique spa experiences, ranging from advanced medical spa treatments to specialised nail and wellness services.


Skin NV Odessa Med Spa focuses on cutting-edge aesthetic and skincare treatments, including laser hair removal, IPL laser, Botox, dermal fillers, microneedling, CoolPeel laser, and unique Salmon DNA facials. This med spa combines advanced technology with expert professionals for non-surgical cosmetic rejuvenation.


LivingYoung Centre provides holistic and anti-aging wellness therapies that concentrate on mental, physical, and spiritual health. Their services feature non-invasive treatments and cosmetic injectables designed to reverse signs of ageing and promote vitality.


Happy Nails & Spa is a local nail salon offering professional nail care services such as liquid gel nails, SNS dipping powder, manicures, pedicures, and waxing, all within a relaxing setting. It prioritises up-to-date nail technology and trends for a unique and affordable experience.


Touch Nail Spa III features natural organic nail and beauty services tailored to individual wellness needs, blending beauty with health-focused treatments.


While Odessa provides these specialised and modern spa and wellness services, for a more historic and mineral spring-based spa experience, nearby Tampa has the Safety Harbor Resort & Spa, which is Florida's only natural mineral springs spa, known for its restorative mineral water treatments and an extensive wellness environment.

Can I cancel my spa hotel reservation on Expedia?

Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline. This is often within 24-48 hours of your scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use Expedia's "Fully refundable property" filter during your search to find the right spa hotel in Odessa for you.

How can I save on a spa hotel in Odessa with Expedia?

Find Odessa spa hotel deals by joining One Key™, Expedia’s free travel rewards program. As a member, you can unlock instant savings with Member Prices when you’re logged in. For a quick weekend retreat, discover last-minute offers.

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