Title: Book the Best Odessa SPA Resorts from CA $131 - Spa Hotels in Odessa, FL | Expedia.ca [Odessa Travel Guide](https://expedia.ca/Odessa.dx6341356)[Hotels in Odessa](https://expedia.ca/Odessa-Hotels.d6341356.Travel-Guide-Hotels)[Vacation Rentals in Odessa](https://expedia.ca/Odessa-Vacation-Rentals.d6341356.Travel-Guide-VacationRentals)[Things to do in Odessa](https://expedia.ca/Things-To-Do-In-Odessa.d6341356.Travel-Guide-Activities)[Odessa Car Rentals](https://expedia.ca/Car-Rentals-In-Odessa.d6341356.Car-Rental-Guide)[Odessa Vacation Packages](https://expedia.ca/Odessa.d6341356.Destination-Travel-Guides) ![Boat House](https://images.trvl-media.com/place/6341356/ac8131d6-5161-427a-9ef7-99d91812f516.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Odessa, FL from CA $131 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Odessa Spa Hotels Tonight [Nov 7 - Nov 8](https://www.expedia.ca/Hotel-Search?regionId=6341356&startDate=2025-11-07&endDate=2025-11-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 8 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6341356&startDate=2025-11-08&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6341356&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6341356&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Odessa Spa Hotels ![Property amenity](https://images.trvl-media.com/lodging/101000000/100700000/100698900/100698855/d49dd50b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/101000000/100700000/100698900/100698855/2eb32b9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/101000000/100700000/100698900/100698855/3154a84c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/101000000/100700000/100698900/100698855/cd18684c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grant Street Inn, an Ascend Collection Hotel Downtown Dunedin 9.6/10 Exceptional (199) "Absolutely phenomenal stay, very clean, conveniently located to a lot of nightlife. Very peaceful, friendly staff and amenities are well worth the stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shamra CA $149 CA $168 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Grant-Street-Inn.h100698855.Hotel-Information) ![Couples treatment rooms, steam room, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/16000000/15920000/15914400/15914352/83a6903a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Room, 1 King Bed (Gulf Front)](https://images.trvl-media.com/lodging/16000000/15920000/15914400/15914352/262b9b5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/16000000/15920000/15914400/15914352/3e998290.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach/ocean view](https://images.trvl-media.com/lodging/16000000/15920000/15914400/15914352/1907db38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Grand Clearwater Beach Clearwater Beach 9.4/10 Exceptional (2786) "Excellent accommodation, staff were friendly & so helpful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) maureen CA $257 CA $346 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Wyndham-Grand-Clearwater-Beach.h15914352.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/30000000/29650000/29643000/29642928/a9443a2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/30000000/29650000/29643000/29642928/a1b8c4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/30000000/29650000/29643000/29642928/31dc57a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/30000000/29650000/29643000/29642928/e152099e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Tampa South Sun Bay South 9.2/10 Wonderful (1000) "Nice and clean with friendly staff. Comfortable bed and great breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vickie CA $115 CA $131 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Tampa-Hotels-Sleep-Inn-Suites-Tampa-South.h29642928.Hotel-Information) ![6 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/16700/16668/363b5cc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/20000/16700/16668/22de563f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/16700/16668/25ac9251.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/20000/16700/16668/173c1756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Innisbrook Resort Palm Harbor 8.4/10 Very good (1001) "Staff was great, clean and spacious rooms. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $193 CA $289 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Innisbrook-Resort.h16668.Hotel-Information) ![Couples treatment rooms, sauna, hot tub, steam room, hot springs](https://images.trvl-media.com/lodging/1000000/30000/20400/20378/acfc999c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/1000000/30000/20400/20378/324f2238.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/20400/20378/2db79476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/20400/20378/e40cafd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Safety Harbor Resort & Spa Trademark Collection by Wyndham Safety Harbor 8.4/10 Very good (1000) "Great property to stay at and the spa is great as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tala CA $251 CA $318 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Safety-Harbor-Resort-Spa-Trademark-Collection-By-Wyndham.h20378.Hotel-Information) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/7000000/6560000/6550100/6550073/935bda8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/7000000/6560000/6550100/6550073/8762bee3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/7000000/6560000/6550100/6550073/b18b6122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/7000000/6560000/6550100/6550073/c21b096a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Epicurean Hotel, Autograph Collection Hyde Park 9.4/10 Exceptional (704) "Love love 10/10 great location staff was amazing . Definitely will stay here again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alana CA $241 CA $276 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Tampa-Hotels-Epicurean-Hotel.h6550073.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/122000000/121420000/121418000/121417969/5599cde0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, oven, stovetop, cookware/dishes/utensils](https://images.trvl-media.com/lodging/122000000/121420000/121418000/121417969/313fed8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/122000000/121420000/121418000/121417969/09eba51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/122000000/121420000/121418000/121417969/612e4ece.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blue Wave Suites Clearwater Beach CA $376 CA $425 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Blue-Wave-Suites.h121417969.Hotel-Information) ![Couples treatment rooms, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2710000/2703500/2703419/0da4df0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2710000/2703500/2703419/5f69c6f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/3000000/2710000/2703500/2703419/d01b652e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2710000/2703500/2703419/w11562h8517x0y0-c8495a6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Clearwater Beach Resort & Spa Clearwater Beach 9.2/10 Wonderful (2044) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $315 CA $412 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Hyatt-Regency-Clearwater-Beach-Resort-Spa.h2703419.Hotel-Information) ![Sauna, hot tub, steam room, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/20000/14200/14189/53f0efd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/1000000/20000/14200/14189/5210f1d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/14200/14189/67b1ebff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/14200/14189/c4ab1506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Opal Sands Resort Clearwater Beach 9.4/10 Exceptional (1149) "clean room, very friendly staff, beautiful amenities, amazing that we can also use the amenities from Opal Sol " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) cristy CA $450 CA $558 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-Opal-Sands-Resort.h14189.Hotel-Information) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/92000000/91790000/91782700/91782613/0b3e6b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/92000000/91790000/91782700/91782613/4a0d1a53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; Mediterranean cuisine](https://images.trvl-media.com/lodging/92000000/91790000/91782700/91782613/393190b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/92000000/91790000/91782700/91782613/a64d3c70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### JW Marriott Clearwater Beach Resort & Spa Clearwater Beach 9.4/10 Exceptional (295) "It was a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael Jamed CA $422 CA $533 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/St-Petersburg-Clearwater-Hotels-JW-Marriott-Clearwater-Beach-Resort-Spa.h91782613.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-21&endDate=2025-11-22®ionId=6341356&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Odessa ### Top Odessa attractions for a relaxing vacation Odessa, Florida, offers a tranquil escape for travellers seeking spa hotels with access to rejuvenating experiences. Begin your day at the picturesque Lake Elda, where you can enjoy a peaceful morning walk or a family-friendly picnic amidst the scenic surroundings. For those looking to unwind, the nearby Serenity Spa provides a range of treatments, from massages to facials, ensuring you leave feeling refreshed. Explore the lush trails of the J.B. Starkey Wilderness Park, perfect for both hiking and cycling, where you can connect with nature and breathe in the fresh air. After a day of adventure, indulge in gourmet dining at local restaurants like the popular Tarpon Springs Sponge Docks, offering fresh seafood and a taste of authentic Florida. Consider staying in the charming, boutique-style hotels in the area that not only provide luxurious amenities but also personalised service to enhance your experience. With the perfect blend of relaxation and exploration, Odessa invites you to create unforgettable memories. ## Top Odessa Hotel Reviews ![Seminole Hard Rock Hotel & Casino Tampa](//images.trvl-media.com/lodging/2000000/1050000/1044200/1044188/6efee43c_y.jpg) ### Seminole Hard Rock Hotel & Casino Tampa 10/10 Excellent "The overall experience was enjoyable. From check-in to checkout. " [](https://expedia.ca/Tampa-Hotels-Seminole-Hard-Rock-Hotel-Casino-Tampa.h1044188.Hotel-Information) ![Wyndham Grand Clearwater Beach](//images.trvl-media.com/lodging/16000000/15920000/15914400/15914352/3e998290_y.jpg) ### Wyndham Grand Clearwater Beach 10/10 Excellent "room was spotless view was beautiful! " [](https://expedia.ca/St-Petersburg-Clearwater-Hotels-Wyndham-Grand-Clearwater-Beach.h15914352.Hotel-Information) ![The Westin Tampa Bay](//images.trvl-media.com/lodging/1000000/10000/1600/1557/5e6ee943_y.jpg) ### The Westin Tampa Bay 10/10 Excellent "I really enjoyed my stay. The room was spotless and smelled amazing. The hotel had a lovely smell as soon as you walk in I really love that they had their own private beach and the jet skis were fun. Will definitely be booking here in the future." [](https://expedia.ca/Tampa-Hotels-Westin-Tampa-Bay-Hotel.h1557.Hotel-Information) ![Hilton Clearwater Beach Resort & Spa](//images.trvl-media.com/lodging/1000000/30000/28100/28023/da46d3f6_y.jpg) ### Hilton Clearwater Beach Resort & Spa 10/10 Excellent "The room was spotless and the staff was really courteous " [](https://expedia.ca/St-Petersburg-Clearwater-Hotels-Hilton-Clearwater-Beach-Resort-Spa.h28023.Hotel-Information) ![Grand Hyatt Tampa Bay](//images.trvl-media.com/lodging/1000000/10000/7600/7558/4855c91c_y.jpg) ### Grand Hyatt Tampa Bay 10/10 Excellent "Wonderful room, soft sheets and amazing staff. They always go out of their way. " [](https://expedia.ca/Tampa-Hotels-Grand-Hyatt-Tampa-Bay.h7558.Hotel-Information) ![Hyatt Regency Clearwater Beach Resort & Spa](//images.trvl-media.com/lodging/3000000/2710000/2703500/2703419/d01b652e_y.jpg) ### Hyatt Regency Clearwater Beach Resort & Spa 10/10 Excellent "Everything was amazing! The room was spotless, the staff was so kind and helpful, and the amenities were excellent. Truly one of the best hotel experiences I’ve had — everything exceeded my expectations! " [](https://expedia.ca/St-Petersburg-Clearwater-Hotels-Hyatt-Regency-Clearwater-Beach-Resort-Spa.h2703419.Hotel-Information) ## Frequently asked questions ### How much does a spa hotel in Odessa cost? > Enjoy staying in a spa hotel in Odessa, with plenty of hotels from CA $131 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, and may vary depending on the location, season, and hotel amenities. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a trip during the weekend or around public holidays. ### Is it cheaper to book a spa hotel in Odessa with flights as part of a package deal? > Booking a hotel and flight package on Expedia can be cheaper than booking flights and hotels separately. Bundling can lead to significant savings, especially for international travel or when booking well in advance. However, savings vary depending on factors like destination, travel dates, and availability, so it's wise to compare options. With access to over 300,000 hotels worldwide, Expedia makes it easy to build the perfect travel package. ### Are there any unique spa experiences available in Odessa? > Yes, Odessa, Florida, offers several unique spa experiences, ranging from advanced medical spa treatments to specialised nail and wellness services. > > > > Skin NV Odessa Med Spa focuses on cutting-edge aesthetic and skincare treatments, including laser hair removal, IPL laser, Botox, dermal fillers, microneedling, CoolPeel laser, and unique Salmon DNA facials. This med spa combines advanced technology with expert professionals for non-surgical cosmetic rejuvenation. > > > > LivingYoung Centre provides holistic and anti-aging wellness therapies that concentrate on mental, physical, and spiritual health. Their services feature non-invasive treatments and cosmetic injectables designed to reverse signs of ageing and promote vitality. > > > > Happy Nails & Spa is a local nail salon offering professional nail care services such as liquid gel nails, SNS dipping powder, manicures, pedicures, and waxing, all within a relaxing setting. It prioritises up-to-date nail technology and trends for a unique and affordable experience. > > > > Touch Nail Spa III features natural organic nail and beauty services tailored to individual wellness needs, blending beauty with health-focused treatments. > > > > While Odessa provides these specialised and modern spa and wellness services, for a more historic and mineral spring-based spa experience, nearby Tampa has the Safety Harbor Resort & Spa, which is Florida's only natural mineral springs spa, known for its restorative mineral water treatments and an extensive wellness environment. ### How can I save on a spa hotel in Odessa with Expedia? > Members always get our best prices. Find our best Odessa spa hotel deals by joining Expedia's free travel rewards program—[One Key™](https://www.expedia.ca/welcome-one-key). As a member, you can unlock instant savings and member perks when you're logged in to your account. For a spontaneous weekend retreat, discover last-minute offers. ### Can I cancel my spa hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline. This is often within 24-48 hours of your scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use Expedia's "Fully refundable property" filter during your search to find the right spa hotel in Odessa for you. ## Explore a world of travel with Expedia - Lodging - More ways to book - [Adults Only Resorts & in Central Florida](https://www.expedia.ca/Central-Florida-Hotels-Adults-Only-Resorts.0-0-d6048177-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Central Florida](https://www.expedia.ca/Central-Florida-Hotels-Beach-Hotel.0-0-d6048177-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Central Florida](https://www.expedia.ca/Central-Florida-Hotels-Boutique-Hotel.0-0-d6048177-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Central Florida](https://www.expedia.ca/Central-Florida-Hotels-Golf-Hotel.0-0-d6048177-tGolfHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Lazy River in Central Florida](https://www.expedia.ca/Central-Florida-Hotels-Hotels-With-A-Lazy-River.0-0-d6048177-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels) - 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