Title: O Brien Vacation Rentals from CA $84: Short-Term Rentals for 2026 | Expedia.ca

[Hotels in O Brien](https://expedia.ca/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.ca/O-Brien.d3000431472.Destination-Travel-Guides)

![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 22 - May 24](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 19 - Jun 21](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 17 - Jul 19](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-07-17&endDate=2026-07-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for O Brien vacation rentals

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/3c8063dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/30e379b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/6eb28891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/2edbe2ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### < 1 Mi From Suwannee River, Hideaway w/ Lanai

[](https://www.expedia.ca/Old-Town-Hotels-1-Mi-From-Suwannee-River.h126526410.Hotel-Information)

Old Town

10/10

Exceptional

(1 review)

"The Air B & B was amazing. The property and the A B & B was awesone, Clean, Quiet and very comfortable. Although some nights got a bit chilly and this property only had AC no heat. We managed just fine. We left it in perfect conditions according to the directions they wanted it left in. Thank you so much and we will be renting again. We also would recommend this to others. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen

CA $167

CA $536 total

includes taxes & fees

Mar 27 - Mar 28

[](https://www.expedia.ca/Old-Town-Hotels-1-Mi-From-Suwannee-River.h126526410.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Queen Bed | Private kitchen](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/00bfc462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/9df0bc6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/300e501a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information)

High Springs

10/10

Exceptional

(190 reviews)

"Room was spotless, property was nicely groomed, snacks, coffee and water was provided overall great trip."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ashley

CA $177

CA $316 total

includes taxes & fees

Mar 31 - Apr 1

[](https://www.expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-08&endDate=2026-04-09&regionId=3000431472&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=VACATION_HOME)

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=CABIN)

Aparthotels

[](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=APART_HOTEL)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=COTTAGE)

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=APARTMENT)

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## Top O Brien Hotel Reviews

![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg)

### Americas Best Value Inn Lake City

8/10 Good

"Clean Room"

[](https://expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information)

![Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e_y.jpg)

### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Perfect getaway for us with our dogs. It was peaceful and relaxing."

[](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information)

![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg)

### Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent

"Good clean place "

[](https://expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg)

### Best Western Plus Lake City

10/10 Excellent

"Room was clean and well kept. The bed was very comfortable"

[](https://expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!](https://images.trvl-media.com/lodging/92000000/91440000/91435900/91435872/c7d330d9_y.jpg)

### Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10/10 Excellent

"We really enjoyed our stay. The host ( Christine) greeted us upon arrival and was eager to share recommendations for things to do in the area. The house was clean, comfortable, and well maintained. The whole family had a blast!"

[](https://expedia.ca/O-Brien-Hotels-Royal-Springs-Riverfront-Retreat.h91435872.Hotel-Information)

![Days Inn by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8_y.jpg)

### Days Inn by Wyndham Lake City I-75

10/10 Excellent

"Accessable really was accessible "

[](https://expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information)

![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg)

### Tru by Hilton Lake City

10/10 Excellent

"Great experience all the amenities needed"

[](https://expedia.ca/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

![Baymont by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094_y.jpg)

### Baymont by Wyndham Lake City I-75

2/10 Terrible

"Horrible property. Room was not as nice as the pictures on hotels Com website. Bathroom was nasty. Door looked like it had been kicked in a few times. We didn't even stay we ended up at La Quinta hotel down the street."

[](https://expedia.ca/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information)

![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg)

### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"The hotels common areas were super clean. We did have an issue with the cleanliness of my room upon check in but the front desk staff was very efficient in handling the matter. Breakfast was decent. Overall good experience! Staff was super friendly!"

[](https://expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

## Find out more about O Brien

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with O Brien. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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- [Vacation Homes in O Brien ](https://expedia.ca/O-Brien-Private-Vacation-Homes.d3000431472-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in O Brien ](https://expedia.ca/O-Brien-Cabins.d3000431472-aaCabins.Travel-Guide-Accommodation)
- [Cottages in O Brien ](https://expedia.ca/O-Brien-Cottages.d3000431472-aaCottages.Travel-Guide-Accommodation)
- [Motels in O Brien ](https://expedia.ca/O-Brien-Motels.d3000431472-aaMotels.Travel-Guide-Accommodation)
- [Apartments in O Brien ](https://expedia.ca/O-Brien-Apartments.d3000431472-aaApartments.Travel-Guide-Accommodation)
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- [B&B in O Brien ](https://expedia.ca/O-Brien-Bed-And-Breakfast.d3000431472-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Guest Houses in O Brien ](https://expedia.ca/O-Brien-Guest-Houses.d3000431472-aaGuestHouses.Travel-Guide-Accommodation)

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