Book The Best Hotels in O Brien, FL for 2026 from CA $92 - Fully Refundable Options

A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.

1. Best Western Plus Lake City

Lake City

marta

CA $116

CA $130 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.

A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

2. Super 8 by Wyndham Lake City

Lake City

Scott

CA $93

CA $104 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern hotel lobby with a fireplace, seating areas, and a bar.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.

3. Comfort Suites Lake City

Lake City

Carma

CA $126

CA $141 total

includes taxes & fees

Oct 6 - Oct 7

A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.

An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.

A Hampton Inn & Suites hotel with a modern design, featuring a prominent red sign, a covered entrance, and a parking area.

4. Hampton Inn & Suites Lake City

Lake City

James

CA $148

CA $167 total

includes taxes & fees

Oct 4 - Oct 5

A covered outdoor area with a paved walkway, benches, and potted plants.

A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.

A bedroom with a bed, a desk, a chair, and a ceiling fan.

5. Cindys Motel

Mayo

Diane

CA $118

CA $127 total

includes taxes & fees

Oct 29 - Oct 30

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

6. Tru by Hilton Lake City

Lake City

Carolina

CA $137

CA $154 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A reception area with a counter, a coffee machine, and a potted plant.

A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

A white building with multiple windows and a sign that reads 'Quality Inn.'

7. Quality Inn Lake City

Lake City

Justin

CA $113

CA $127 total

includes taxes & fees

Oct 28 - Oct 29

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

8. Fairfield Inn & Suites Lake City

Lake City

Jordan

CA $133

CA $150 total

includes taxes & fees

Oct 25 - Oct 26

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.

9. Americas Best Value Inn Lake City

Lake City

Sara

CA $91

CA $103 total

includes taxes & fees

Sep 29 - Sep 30

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

A modern hotel lobby with a reception desk, seating areas, and a large screen.

A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

10. Home2 Suites by Hilton Lake City

Lake City

William

CA $155

CA $175 total

includes taxes & fees

Oct 4 - Oct 5

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A wooden cabin with a kitchen, a bathroom, and a loft bedroom.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A serene lakeside campsite with picnic tables and chairs.

11. Suwannee River Rendezvous

Mayo

Beth

CA $127

CA $171 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with two beds, a TV, a desk, and a painting of a sunset.

A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

A reception area with a wooden counter, a clock, and a computer on a desk.

A hotel room with a large bed, a bedside table, a nightstand, a window, and a bathroom with a toilet and sink.

12. Days Inn by Wyndham Lake City I-75

Lake City

Wilberd

CA $89

CA $101 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.

A hotel room with two beds, a TV, a desk with a lamp, and a window with blinds.

A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.

A hotel lobby with multiple seating areas, a bar, and an elevator.

13. Holiday Inn & Suites Lake City by IHG

Lake City

C.jeffery

CA $143

CA $161 total

includes taxes & fees

Oct 4 - Oct 5

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

A hotel room with a bed, desk, chair, and sofa.

14. Quality Inn White Springs Suwanee

White Springs

Pennee

CA $99

CA $109 total

includes taxes & fees

Sep 30 - Oct 1

A room with a window, a sofa, a table, and a wall-mounted heater.

A hotel room with two beds, a desk, a chair, a window with a view, and a wall-mounted lamp.

A building with a flat roof, large windows, and a parking lot in front.

A reception desk with a large number '6' sign, a mounted television, and a digital information kiosk.

15. Motel 6 – Lake City, Fl – Medical Center

Lake City

Pennee

CA $88

CA $99 total

includes taxes & fees

Oct 4 - Oct 5

A modern restaurant with a central counter, red chairs, and a blue and white color scheme.

A reception area with a counter, seating, and a fireplace.

A conference room with a stone fireplace, a flat-screen TV, and two office chairs.

A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.

16. Holiday Inn Express & Suites Live Oak by IHG

Live Oak

Tammy

CA $161

CA $177 total

includes taxes & fees

Oct 26 - Oct 27

A hotel reception area with a reception desk, seating area, and a view of the parking lot.

A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.

A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.

A hotel room with two beds, a bedside table with a lamp, a phone, and a window with curtains.

17. Econo Lodge Live Oak

Live Oak

Ryan

CA $109

CA $120 total

includes taxes & fees

Sep 29 - Sep 30

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

18. Courtyard By Marriott Lake City

Lake City

Angel

CA $151

CA $170 total

includes taxes & fees

Oct 4 - Oct 5

A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a bathroom visible in the background.

A gazebo with a red roof and green walls, surrounded by trees and a pool.

19. Baymont by Wyndham Lake City I-75

Lake City

Julie

CA $82

CA $92 total

includes taxes & fees

Sep 29 - Sep 30

A commercial kitchen with coffee machines, a beverage dispenser, and various kitchen appliances.

A hotel room with a desk, chair, bed, TV, microwave, refrigerator, and a painting on the wall.

A rectangular swimming pool with a safety ladder, surrounded by a low hedge and palm trees.

A hotel room with a bed, desk, chair, television, and a bathroom visible in the background.

20. Quality Inn & Suites Live Oak I-10 Exit 283

Live Oak

Kayla

CA $120

CA $131 total

includes taxes & fees

Oct 6 - Oct 7

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Fairfield Inn & Suites Lake City

10/10 Excellent

"Wonderful stay! ☺️"

Days Inn by Wyndham Lake City I-10

8/10 Good

"Pretty good for a budget hotel. I would stay again. Breakfast was simple with oatmeal cereal milk with granola toppings yogurt toast coffee apples. Did what I needed."

Best Western Plus Lake City

10/10 Excellent

"This was really a great hotel! Everything in our room was CLEAN, CLEAN. I was very impressed. Also, the staff was very friendly during our check-in. Love great customer service. Will be booking here again."

Tru by Hilton Lake City

10/10 Excellent

"Very clean and smelled delightful. Friendly welcoming staff. Cool hotel. Will definitely stay here again."

Baymont by Wyndham Lake City I-75

8/10 Good

"Little worn"

Comfort Suites Lake City

10/10 Excellent

"My stay was welcoming and warm."

Hampton Inn & Suites Alachua I-75

10/10 Excellent

"Everything was Excellent!!"

Courtyard By Marriott Lake City

10/10 Excellent

"Wonderful place, clean and conform beds."

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10/10 Excellent

"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL

CA $82

CA $92 total

Sep 29 - Sep 30

includes taxes & fees

5/10 (1,001 reviews)