
Find hotels in O Brien, FL from CA $79
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in O Brien
Pet friendly
Apartment
Check prices for these dates
Our top choices for O Brien hotels

1. Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake CityLake City
9.0 out of 10, Wonderful, (300 reviews)
The price is CA $134
CA $151 total
includes taxes & fees
Dec 5 - Dec 6

2. Comfort Suites Lake City
Comfort Suites Lake CityLake City
9.4 out of 10, Exceptional, (1,001 reviews)
The price is CA $133
CA $150 total
includes taxes & fees
Dec 6 - Dec 7

3. Tru by Hilton Lake City
Tru by Hilton Lake CityLake City
9.2 out of 10, Wonderful, (1,001 reviews)
The price is CA $133
CA $149 total
includes taxes & fees
Dec 6 - Dec 7

4. Best Western Plus Lake City
Best Western Plus Lake CityLake City
9.0 out of 10, Wonderful, (1,139 reviews)
The price is CA $114
CA $128 total
includes taxes & fees
Dec 1 - Dec 2

5. La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake CityLake City
8.8 out of 10, Excellent, (1,208 reviews)
The price is CA $133
CA $150 total
includes taxes & fees
Dec 2 - Dec 3

6. Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake CityLake City
9.4 out of 10, Exceptional, (1,000 reviews)
The price is CA $139
CA $156 total
includes taxes & fees
Dec 13 - Dec 14

7. Quality Inn Lake City
Quality Inn Lake CityLake City
8.2 out of 10, Very good, (1,001 reviews)
The price is CA $98
CA $110 total
includes taxes & fees
Dec 13 - Dec 14

8. Americas Best Value Inn Lake City
Americas Best Value Inn Lake CityLake City
8.6 out of 10, Excellent, (1,000 reviews)
The price is CA $101
CA $114 total
includes taxes & fees
Nov 15 - Nov 16

9. Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake CityLake City
7.4 out of 10, Good, (767 reviews)
The price is CA $87
CA $98 total
includes taxes & fees
Dec 1 - Dec 2

10. Courtyard By Marriott Lake City
Courtyard By Marriott Lake CityLake City
9.6 out of 10, Exceptional, (315 reviews)
The price is CA $153
CA $172 total
includes taxes & fees
Nov 22 - Nov 23

11. Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHGLake City
8.6 out of 10, Excellent, (1,001 reviews)
The price is CA $133
CA $149 total
includes taxes & fees
Dec 13 - Dec 14

12. TownePlace Suites by Marriott Lake City
TownePlace Suites by Marriott Lake CityLake City
9.6 out of 10, Exceptional, (152 reviews)
The price is CA $184
CA $207 total
includes taxes & fees
Nov 15 - Nov 16

14. Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake CityLake City
9.4 out of 10, Exceptional, (834 reviews)
The price is CA $169
CA $190 total
includes taxes & fees
Nov 22 - Nov 23

15. Cindys Motel
Cindys MotelMayo
8.8 out of 10, Excellent, (142 reviews)
The price is CA $121
CA $131 total
includes taxes & fees
Dec 14 - Dec 15

16. Quality Inn White Springs Suwanee
Quality Inn White Springs SuwaneeWhite Springs
7.2 out of 10, Good, (710 reviews)
The price is CA $86
CA $95 total
includes taxes & fees
Dec 6 - Dec 7

17. Quality Inn & Suites Live Oak I-10 Exit 283
Quality Inn & Suites Live Oak I-10 Exit 283Live Oak
7.0 out of 10, Good, (600 reviews)
The price is CA $119
CA $131 total
includes taxes & fees
Nov 22 - Nov 23

18. Holiday Inn Express & Suites Live Oak by IHG
Holiday Inn Express & Suites Live Oak by IHGLive Oak
8.4 out of 10, Very good, (901 reviews)
The price is CA $141
CA $155 total
includes taxes & fees
Dec 13 - Dec 14

19. Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75Lake City
7.6 out of 10, Good, (1,000 reviews)
The price is CA $96
CA $108 total
includes taxes & fees
Dec 1 - Dec 2

20. Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75Lake City
5.0 out of 10, (1,001 reviews)
The price is CA $82
CA $93 total
includes taxes & fees
Nov 15 - Nov 16
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

More cheap stays in O Brien

Quality Inn Lake City
285 Sw Commerce Dr Lake City FL
The price is CA $98 per night from Dec 13 to Dec 14
CA $98
CA $110 total
Dec 13 - Dec 14
includes taxes & fees
Hotels in O Brien with star rating

3 Star Hotels
35 properties

2 Star Hotels
39 properties
Frequently asked questions
Explore a world of travel with Expedia
- Lake Butler Hotels
- Budget Inn of Jasper
- Hotels near San Felasco Hammock Preserve State Park
- Hotels near Manatee Springs State Park
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Gateway Inn
- Rv Parks in Alachua
- Wyndham Hotels in High Springs
- Aparthotels in Lake City
- Kokomo Farms
- Cheap Hotels in Old Town
- Cabin Rentals in Mayo
- Sanderson Hotels
- Madison Hotels
- Trenton Hotels
- Hotels near Ichetucknee Springs State Park
- Hotels near Spirit of the Suwannee Music Park
- Cottages in O Brien
- Live Oak Hotels
- Jena Hotels
- Rv Parks in Lake City
- Spa Hotels in Lake City
- Motel 6 Hotels in Lake City
- Quality Inn & Suites Live Oak I
- Hotels near Wes Skiles Peacock Springs State Park
- Mayo Hotels
- Athena Hotels
- Apartments in Newberry
- Alachua Hotels
- Private 12 acre Ranch sleeps up to 8 on The Santa Fe River.
- Gainesville Hotels
- Vv’s Villa Steinhatchee Landing Resort
- Wyndham Hotels in Mcalpin
- Keaton Beach Hotels
- Jasper Hotels
- American Inn and Suites
- Quality Inn White Springs Suwanee
- 5 Star Hotels in Trenton
- Vacation Homes in Athena
- Holiday Inn Express & Suites Live Oak by IHG
- Cadillac Motel Fanning Springs
- Clarion Pointe Alachua
- Cross City Hotels
- Cheap Hotels in Jasper
- Hotels near Yogi Bear's Jellystone Park
- The Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee
- Cabin Rentals in Jasper
- Cabin w/ Fire Pit
- Hotels near Taylor County Sports Complex
- Motels in Fanning Springs
- Old Town Hotels
- High Springs Hotels
- Gulf Breeze Condo #208
- Guest Houses in Suwannee County
- The Happy House Tiny Guest House
- Hotels near O'Leno State Park
- Rv Parks in Jasper
- Hillside Abode
- Newberry Hotels
- Lake City Hotels
- Apartments in Lee
- Quality Inn Alachua
- Villas in Lee
- B&B in O Brien
- Motels in Andrews
- Motels in Live Oak
- Perry Hotels
- Steinhatchee Hotels
- Hilton Hotels in Trenton
- Cottages in West Lake








































































