A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

1. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
"Stayed here on the way to Disney so wouldn't have to drive so far one way for the family. It was a nice place to stay."
United States
Anthony
The price is CA $134
CA $151 total
includes taxes & fees
Dec 5 - Dec 6
Fairfield Inn & Suites Lake City

2. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,001 reviews)
"Overall great stay!"
United States
Jim
The price is CA $133
CA $150 total
includes taxes & fees
Dec 6 - Dec 7
Comfort Suites Lake City

3. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,001 reviews)
"Always a great stay."
United States
Gary
The price is CA $133
CA $149 total
includes taxes & fees
Dec 6 - Dec 7
Tru by Hilton Lake City

4. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,139 reviews)
"Convenient clean and met our needs for the weekend"
United States
Sherry
The price is CA $114
CA $128 total
includes taxes & fees
Dec 1 - Dec 2
Best Western Plus Lake City

5. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
"Very nice visit, very clean room, excellent staff, great breakfast, easy parking"
United States
Emory
The price is CA $133
CA $150 total
includes taxes & fees
Dec 2 - Dec 3
La Quinta Inn & Suite by Wyndham Lake City

6. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"I have stayed here several times. Staff is at least very friendly and accommodating properties very clean. We enjoyed our stay."
United States
Eileen
The price is CA $139
CA $156 total
includes taxes & fees
Dec 13 - Dec 14
Hampton Inn & Suites Lake City

7. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,001 reviews)
"Very nice hotel!"
United States
Mary
The price is CA $98
CA $110 total
includes taxes & fees
Dec 13 - Dec 14
Quality Inn Lake City

8. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"This is a great hotel for the price. Clean, room was small. Close to restaurants and parking lot is well lite."
United States
Brenda
The price is CA $101
CA $114 total
includes taxes & fees
Nov 15 - Nov 16
Americas Best Value Inn Lake City

9. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
"Complimentary dinner and cooked to order eggs at breakfast. Neat and clean. Comfy bed."
United States
Allan
The price is CA $87
CA $98 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Lake City

10. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (315 reviews)
"Nice overnight stay."
United States
Zanza
The price is CA $153
CA $172 total
includes taxes & fees
Nov 22 - Nov 23
Courtyard By Marriott Lake City

11. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
"Next time I am needing motel in Lake City, will plan to stay at this location."
United States
William
The price is CA $133
CA $149 total
includes taxes & fees
Dec 13 - Dec 14
Holiday Inn & Suites Lake City by IHG

12. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (152 reviews)
"Very clean! Comfy beds!"
United States
John
The price is CA $184
CA $207 total
includes taxes & fees
Nov 15 - Nov 16
TownePlace Suites by Marriott Lake City

13. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (623 reviews)
"This is the second time I’ve stayed at this hotel. Convenient to restaurants and gas stations. Look forward to staying again."
United States
Gerardo
The price is CA $88
CA $99 total
includes taxes & fees
Nov 15 - Nov 16
Regal Inn

14. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (834 reviews)
"Big, clean room and the staff was very friendly"
United States
Laurie
The price is CA $169
CA $190 total
includes taxes & fees
Nov 22 - Nov 23
Home2 Suites by Hilton Lake City

15. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (142 reviews)
"It was a clean room. We could park outside our room door."
United States
Keith
The price is CA $121
CA $131 total
includes taxes & fees
Dec 14 - Dec 15
Cindys Motel

16. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (710 reviews)
"Great breakfast options quiet clean place to stay"
United States
Pennee
The price is CA $86
CA $95 total
includes taxes & fees
Dec 6 - Dec 7
Quality Inn White Springs Suwanee

17. Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.0 out of 10, Good, (600 reviews)
"Everything good"
United States
Guillermo
The price is CA $119
CA $131 total
includes taxes & fees
Nov 22 - Nov 23
Quality Inn & Suites Live Oak I-10 Exit 283

18. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (901 reviews)
"Nice place"
United States
Andrew
The price is CA $141
CA $155 total
includes taxes & fees
Dec 13 - Dec 14
Holiday Inn Express & Suites Live Oak by IHG

19. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,000 reviews)
"Nice breakfast."
United States
Nathan
The price is CA $96
CA $108 total
includes taxes & fees
Dec 1 - Dec 2
Days Inn by Wyndham Lake City I-75

20. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
"Easy parking room clean"
United States
Pennee
The price is CA $82
CA $93 total
includes taxes & fees
Nov 15 - Nov 16
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

A calm river surrounded by trees reflecting in the water.

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Frequently asked questions

What is the best area to stay in O Brien?
The best area to stay in O'Brien, Florida, is along the Suwannee River, particularly around the public boat ramps and access points.

This area is the main draw for visitors to O'Brien, as it provides direct access to the natural beauty and recreational opportunities of the Suwannee River. You'll find a scattering of accommodations, from holiday rentals to small, independent motels, often with direct riverfront access or just a short drive away. This allows for convenient enjoyment of activities like fishing, kayaking, and boating.

Families will find this area particularly appealing due to the easy access to water-based activities. Many properties offer amenities like barbecue areas and space for children to play, making it simple to enjoy the outdoors together. The nearby Spirit of the Suwannee Music Park also hosts various events throughout the year, which can be a fun addition to a family holiday.

For couples looking for a relaxed escape, staying by the river offers a peaceful setting. You can enjoy quiet evenings by the water, explore the river's springs, or simply unwind away from city life.
When is the best time to go to O Brien?
The best time to visit O'Brien, Florida, is typically during the spring (March to May) and autumn (September to November) months.

During these periods, the weather is generally mild and pleasant, with comfortable temperatures, making it ideal for enjoying outdoor activities like swimming, fishing, and exploring the natural springs without the intense heat and humidity of summer or the cooler temperatures of winter. The spring also brings blooming wildflowers, adding to the area's natural beauty.

For couples looking for a relaxing escape, these shoulder seasons offer a good balance of agreeable weather and fewer crowds compared to peak summer. You'll find it easier to enjoy the tranquility of the Ichetucknee Springs State Park or the Suwannee River without feeling overwhelmed by other visitors.

Families travelling with children might also find these times more comfortable for outdoor adventures.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in O Brien.
How much is the nightly rate at a O Brien hotel?
Prices for hotels in O Brien often vary, but you can find a great deal from CA $79 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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