Title: 2 Stars Hotels in O Brien, Florida from CA $78 - Find Cheap O Brien Hotels With 2 Stars | Expedia.ca [O Brien Travel Guide](https://expedia.ca/O-Brien.dx3000431472)[Hotels in O Brien](https://expedia.ca/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.ca/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.ca/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.ca/O-Brien.d3000431472.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Dr\_\_Vlad # 2 Stars Hotels in O Brien, Florida from CA $78 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on O Brien 2 Star Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-11-04&endDate=2025-11-05&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-11-05&endDate=2025-11-06&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-11-14&endDate=2025-11-16&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top O Brien 2 Star Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/dc8aa87c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/fb3e9b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lake City Lake City 9.2/10 Wonderful (1051) "Staff were friendly and helpful. Located right off I75 which was very convenient. Breakfast was good and area clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $117 CA $132 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/6a43fc6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast on weekdays](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/81ba003e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/b562f911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suite by Wyndham Lake City Lake City 8.8/10 Excellent (1007) "It felt very safe and my pppet was welcomed. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $132 CA $148 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/1f67a534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/bfe0c823.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/0f35d9d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/5b344087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Lake City Lake City 9.2/10 Wonderful (1016) "Good hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Frank CA $153 CA $172 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/4977ae81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/695b0a91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/1d6290c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/70b1f0e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Lake City Lake City 9.6/10 Exceptional (1007) "Amazing place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Felix CA $131 CA $147 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/82e386c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/89f48c41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/cb41e4e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Live Oak by IHG Live Oak 8.2/10 Very good (761) "Our stay was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Francisco CA $188 CA $207 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/e9ad0459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, Select Comfort beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/cf4e1088.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lake City Lake City 9.4/10 Exceptional (1000) "It was a great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Miranda CA $148 CA $167 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/ad8fe69d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/645a482b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/8ce5f9ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Lake City Lake City 8.8/10 Excellent (1000) "Reasonably priced, nice and clean, easy access to I 75" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dianne CA $94 CA $106 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/590bae4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/98a5e0bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Multiple Beds, Non Smoking (Oversize)](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/5173400f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Lake City I-75 Lake City 5.0/10 (1001) "Friendly staff checked me in. Clean room " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey CA $81 CA $91 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/47bbd7f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/e1dc2812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 7:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/63478939.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/0ead3b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn White Springs Suwanee Live Oak 7.2/10 Good (599) "The room was ok (not good, not bad, just ok). The breakfast was also ok. The room was a bit small for three people." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Sichao CA $96 CA $105 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/529b1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/04b1a652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/8fa5709a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-75 Lake City 7.4/10 Good (1001) "Very clean! Very friendly staff! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marleis CA $101 CA $113 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/9a0ddc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/00752d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/8207aeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/w4000h2664x0y0-4664f427.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Lake City Lake City 9.0/10 Wonderful (141) "Yes great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $138 CA $155 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/86b658ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/0840ecb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/9444fa12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/w3837h2160x3y0-3ebb9ae9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 – Lake City, Fl – Medical Center Lake City 8.2/10 Very good (28) "Clean and spacious room, helpful staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $70 CA $78 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) ![Individually decorated, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/9948e87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/944a276f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/e76f188c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/a71dca11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-10 Lake City 6.8/10 (1002) "It s a very nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denise CA $84 CA $95 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/add6c913.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/6ed37200.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/55dd4dff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/b1012fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Lake City Lake City 7.2/10 Good (655) "Would recommend a nice hotel to stay at while traveling " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $95 CA $107 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) ![Standard Cabin, 1 Queen Bed | Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/a2ef87a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Cabin, 2 Queen Beds | Private kitchen](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/8ad8644d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Cabin, 1 Queen Bed](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5671b438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/4879ff7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy High Springs 10/10 Exceptional (132) "Great place to getaway. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carlyson Barros CA $181 CA $261 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Room](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/fe90356d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/66db6d5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/5794d577.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### BlueGem Motel High Springs 9.2/10 Wonderful (381) "Great hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wesley CA $138 CA $156 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/adf8855d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/2a6768bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/55b69a67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/6579eaa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Alachua Alachua 4.8/10 (593) "Staff was helpful and so courteous.." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian CA $90 CA $101 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Gainesville-Hotels-Americas-Best-Value-Inn-Alachua.h537189.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/cbec2bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/05952e37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/494a0351.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/d203aab4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Lake City Lake City 7.8/10 Good (944) "Everything was great about this property and the staff were very friendly and accommodating. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew CA $98 CA $110 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn-Lake-City.h484004.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/a952eda0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/68371972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/847fac5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/35661d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Alachua I-75 Alachua 9.4/10 Exceptional (464) "We would definitely stay here again if we are ever in this area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) KAREN CA $154 CA $174 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information) ![Premium bedding, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/c251e287.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/62d30ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/cb9a0faf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Living room](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/d6f46a2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palms Garden Inn Lake City 7.4/10 Good (570) "Nice clean room with a big bed Good AC" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mike horne CA $91 CA $103 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in O Brien. ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 16367 NW 167TH BLVD, Alachua, FL CA $171 CA $193 total Nov 9 - Nov 10 includes taxes & fees 9.4/10 Exceptional! (1,002 reviews) [](https://expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![Holiday Inn & Suites Lake City by IHG](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/5d9b579a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn & Suites Lake City by IHG 213 Sw Commerce Dr, Lake City, FL CA $134 CA $150 total Nov 9 - Nov 10 includes taxes & fees 8.6/10 Excellent! (1,003 reviews) [](https://expedia.ca/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information) ![Courtyard By Marriott Lake City](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/9bb4eff5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Courtyard By Marriott Lake City 3004 West US HWY 90, Lake City, FL CA $150 CA $169 total Nov 16 - Nov 17 includes taxes & fees 9.4/10 Exceptional! (164 reviews) [](https://expedia.ca/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) Still don't see what you're looking for? [See all properties in O Brien.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F11%2F2025&endDate=07%2F11%2F2025®ionId=3000431472&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F11%2F2025&endDate=07%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F11%2F2025&endDate=07%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F11%2F2025&endDate=07%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F11%2F2025&endDate=07%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F11%2F2025&endDate=07%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about O Brien Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities. [See all hotels in O Brien](https://www.expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20&adults=2®ionId=3000431472) ![An amazing state Park 2 hours drive from Orlando. Swimming and snorkeling in this crystal clear water is allowed and i really recommend to do it! 🐟🐢](https://images.trvl-media.com/place/6286968/6ef14131-623c-497c-b3f3-edb4a56b8714.jpg?impolicy=fcrop&w=899&h=506&p=1&q=high) Photo by Dr\_\_Vlad ## Top O Brien Hotel Reviews ![Americas Best Value Inn Lake City](//images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692_y.jpg) ### Americas Best Value Inn Lake City 10/10 Excellent "Yes, the room was very nice " [](https://expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![BlueGem Motel](//images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02_y.jpg) ### BlueGem Motel 10/10 Excellent "Everything was great" [](https://expedia.ca/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) ![Motel 6 – Lake City, Fl – Medical Center](//images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/86b658ba_y.jpg) ### Motel 6 – Lake City, Fl – Medical Center 10/10 Excellent "Scott checked me in. He was delightful and informative. Room very nice and clean. Comfy love seat. Bed comfy. Soft pure white towels. Great refrigerator and microwave. Great water pressure for a wonderful hot shower after a long road trip. Right next door is an I-Hop and Steak & Shake. A lot of yard space to walk my dog & dogs are welcome free of charge. " [](https://expedia.ca/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) ![Days Inn by Wyndham Lake City I-75](//images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8_y.jpg) ### Days Inn by Wyndham Lake City I-75 10/10 Excellent "Very clean! Very friendly staff! " [](https://expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy](//images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/fce767a1_y.jpg) ### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Such a happy experience and makes having a pet even more fun. Can wait to do it again! " [](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ## Find out more about O Brien Want to get out of town on the cheap? Thanks to the low rates and great discounts at the top 2 Stars hotels in O Brien, O Brien you can sneak away on the trip of your dreams with plenty of cash to spare. In addition to the friendly staff and well-maintained surroundings, you’ll find comfortable rooms, complimentary bath products, and quiet sleeping areas, so you can kick back with all the basic conveniences after a long day. Plus, these properties are perfect, if you need a jumping-off point for exploring the local attractions. Several of the best hotels with 2 Stars in O Brien are situated just a stone’s throw from both public transportation and the city’s main freeways. Use the travel tools at Expedia.ca to search for options near your favorite neighborhood, find a cheap deal, and book your room. 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