Title: 2 Stars Hotels in O Brien, Florida from CA $75 - Find Cheap O Brien Hotels With 2 Stars | Expedia.ca [O Brien Travel Guide](https://expedia.ca/O-Brien.dx3000431472)[Hotels in O Brien](https://expedia.ca/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.ca/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.ca/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.ca/O-Brien.d3000431472.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Dr\_\_Vlad # 2 Stars Hotels in O Brien, Florida from CA $75 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on O Brien 2 Star Hotels Tonight [Oct 30 - Oct 31](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-10-30&endDate=2025-10-31&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 31 - Nov 1](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-10-31&endDate=2025-11-01&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top O Brien 2 Star Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/fb3e9b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/f5ec1000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lake City Lake City 9.2/10 Wonderful (1044) "Good breakfast, very clean room, great decor and overall a nice play to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Francisco CA $116 CA $130 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/b562f911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/c38f0eff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast on weekdays](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/81ba003e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suite by Wyndham Lake City Lake City 8.8/10 Excellent (1004) "We have stayed here multiple times, always convenient and our choice when passing through Lake City " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $133 CA $150 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/1f67a534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/fad9110f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/0f35d9d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/bfe0c823.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Lake City Lake City 9.2/10 Wonderful (1010) "Good hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Frank CA $152 CA $171 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/4977ae81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/1d6290c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/70b1f0e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/bb1585dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Lake City Lake City 9.6/10 Exceptional (1001) "We love to stop here when traveling to Orlando" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bridget CA $131 CA $147 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/cb41e4e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/893e3583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/89f48c41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Live Oak by IHG Live Oak 8.4/10 Very good (758) "Have stayed here whenever we are in town. Always god stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregg CA $174 CA $192 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/e9ad0459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/0b9cfe16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lake City Lake City 9.4/10 Exceptional (1001) "It was a great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Miranda CA $140 CA $158 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/8ce5f9ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/645a482b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Lake City Lake City 8.8/10 Excellent (1001) "Great people, nice place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $99 CA $112 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/590bae4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/98a5e0bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/de24c9b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Lake City I-75 Lake City 5.0/10 (1000) "Just a perfect place to take a break while traveling. Clean,comfortable and a great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cris CA $81 CA $91 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/47bbd7f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/fd7eab0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/0ead3b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 7:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/63478939.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn White Springs Suwanee Live Oak 7.2/10 Good (595) "Clean rooms, very friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristin L CA $82 CA $90 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/04b1a652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/529b1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/90e37569.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-75 Lake City 7.4/10 Good (1000) "Very clean! Very friendly staff! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marleis CA $103 CA $115 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/9a0ddc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/69fc9dfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/00752d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/8207aeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Lake City Lake City 9.0/10 Wonderful (139) "Friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zohar CA $137 CA $154 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/86b658ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/d3a1e6f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/9444fa12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/0840ecb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 – Lake City, Fl – Medical Center Lake City 8.4/10 Very good (21) "Clean and spacious room, helpful staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $67 CA $75 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) ![Individually decorated, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/9948e87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/944a276f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/a71dca11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/e76f188c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-10 Lake City 6.8/10 (1002) "Friendly staff, quiet, convenient, easy parking, clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $84 CA $94 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/add6c913.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/55dd4dff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/6ed37200.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/b1012fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Lake City Lake City 7.2/10 Good (652) "Very friendly staff, delicious breakfast and dinner, clean pool, spacious room. Best hotel in the last 4 years within same price range" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marina CA $94 CA $105 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) ![Standard Cabin, 1 Queen Bed | Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/a2ef87a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/4879ff7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Cabin, 2 Queen Beds | Private kitchen](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/8ad8644d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/9c577e96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy High Springs 10/10 Exceptional (131) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joey CA $180 CA $259 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/dffd0064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Room](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/fe90356d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/5794d577.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### BlueGem Motel High Springs 9.2/10 Wonderful (380) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wesley CA $129 CA $146 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/adf8855d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/2a6768bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/55b69a67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/540000/537200/537189/6579eaa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Alachua Alachua 4.8/10 (591) "Staff very helpful and property clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donna CA $94 CA $105 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Gainesville-Hotels-Americas-Best-Value-Inn-Alachua.h537189.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/cbec2bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/494a0351.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/d203aab4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/2acb054a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Lake City Lake City 7.8/10 Good (942) "Very nice place, would definitely stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gerald CA $105 CA $119 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn-Lake-City.h484004.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/a952eda0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/2dd8879c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/68371972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/847fac5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Alachua I-75 Alachua 9.4/10 Exceptional (464) "Nice room only there for one night" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laryssa CA $157 CA $176 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information) ![Premium bedding, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/c251e287.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/cd217d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/cb9a0faf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/62d30ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palms Garden Inn Lake City 7.4/10 Good (569) "Nice clean room with a big bed Good AC" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mike horne CA $91 CA $102 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in O Brien. ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 16367 NW 167TH BLVD, Alachua, FL CA $170 CA $191 total Nov 9 - Nov 10 includes taxes & fees 9.4/10 Exceptional! (1,000 reviews) [](https://expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![Holiday Inn & Suites Lake City by IHG](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/5d9b579a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn & Suites Lake City by IHG 213 Sw Commerce Dr, Lake City, FL CA $130 CA $146 total Nov 2 - Nov 3 includes taxes & fees 8.4/10 Very Good! (1,001 reviews) [](https://expedia.ca/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information) ![Courtyard By Marriott Lake City](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/9bb4eff5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Courtyard By Marriott Lake City 3004 West US HWY 90, Lake City, FL CA $137 CA $154 total Nov 9 - Nov 10 includes taxes & fees 9.4/10 Exceptional! (159 reviews) [](https://expedia.ca/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) Still don't see what you're looking for? [See all properties in O Brien.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025®ionId=3000431472&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025®ionId=3000431472&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about O Brien Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities. [See all hotels in O Brien](https://www.expedia.ca/Hotel-Search?startDate=2025-11-13&endDate=2025-11-14&adults=2®ionId=3000431472) ![An amazing state Park 2 hours drive from Orlando. Swimming and snorkeling in this crystal clear water is allowed and i really recommend to do it! 🐟🐢](https://images.trvl-media.com/place/6286968/6ef14131-623c-497c-b3f3-edb4a56b8714.jpg?impolicy=fcrop&w=899&h=506&p=1&q=high) Photo by Dr\_\_Vlad ## Top O Brien Hotel Reviews ![Days Inn by Wyndham Lake City I-75](//images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8_y.jpg) ### Days Inn by Wyndham Lake City I-75 10/10 Excellent "Very clean! Very friendly staff! " [](https://expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Americas Best Value Inn Lake City](//images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692_y.jpg) ### Americas Best Value Inn Lake City 10/10 Excellent "Reasonably priced, nice and clean, easy access to I 75" [](https://expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy](//images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/fce767a1_y.jpg) ### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Such a happy experience and makes having a pet even more fun. Can wait to do it again! " [](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Palms Garden Inn](//images.trvl-media.com/lodging/1000000/50000/40800/40753/c251e287_y.jpg) ### Palms Garden Inn 10/10 Excellent "Nice clean room with a big bed Good AC" [](https://expedia.ca/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) ![Motel 6 – Lake City, Fl – Medical Center](//images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/86b658ba_y.jpg) ### Motel 6 – Lake City, Fl – Medical Center 10/10 Excellent "The room was Very Big, with separate seating area. Clerk was real friendly & helpful. Very clean bathroom, shower." [](https://expedia.ca/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) ![BlueGem Motel](//images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02_y.jpg) ### BlueGem Motel 10/10 Excellent "The room was spacious, the bed was super comfortable and there was everything I needed for my overnight stay. There is a microwave/confection oven and mini fridge in the room, as well as a mini coffee maker. I had a great day, and would definitely stay here again if ever in the area." [](https://expedia.ca/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) ## Find out more about O Brien Want to get out of town on the cheap? Thanks to the low rates and great discounts at the top 2 Stars hotels in O Brien, O Brien you can sneak away on the trip of your dreams with plenty of cash to spare. In addition to the friendly staff and well-maintained surroundings, you’ll find comfortable rooms, complimentary bath products, and quiet sleeping areas, so you can kick back with all the basic conveniences after a long day. Plus, these properties are perfect, if you need a jumping-off point for exploring the local attractions. Several of the best hotels with 2 Stars in O Brien are situated just a stone’s throw from both public transportation and the city’s main freeways. Use the travel tools at Expedia.ca to search for options near your favorite neighborhood, find a cheap deal, and book your room. 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