Title: Book The Best Hotels in O Brien, FL for 2026 from CA $60 - Fully Refundable Options - Expedia.ca [Vacation Rentals in O Brien](https://expedia.ca/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.ca/O-Brien.d3000431472.Destination-Travel-Guides) ![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in O Brien Family friendly [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&amenities=POOL) Cabin [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&lodging=CABIN) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&lodging=APARTMENT) Cottage [](https://www.expedia.ca/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-04-17&d1=2026-04-17&endDate=2026-04-19&d2=2026-04-19&lodging=COTTAGE) ## Check prices for these dates Tonight [Apr 3 - Apr 4](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-04-03&endDate=2026-04-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 4 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-04-04&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=3000431472&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for O Brien hotels ![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed | Private kitchen](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/00bfc462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/9df0bc6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed (View) | Private kitchen](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/76a693e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) High Springs 10/10 Exceptional (196 reviews) "Perfect getaway for us with our dogs. It was peaceful and relaxing." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leila CA $179 CA $319 total includes taxes & fees Apr 20 - Apr 21 [](https://www.expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/a3ee2a3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden view](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/0b12a87b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/42e07503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/86100bd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vista Verde Farm Retreat [](https://www.expedia.ca/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information) Lake City 9.8/10 Exceptional (17 reviews) "Beautiful spot with friendly horses :) " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dagmara CA $141 CA $252 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/0ead3b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/e1dc2812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/82bfa53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/f498da18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn White Springs Suwanee [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) Live Oak 7.2/10 Good (654 reviews) "Great breakfast! The best staff you can get at a hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) vicki CA $84 CA $92 total includes taxes & fees Apr 8 - Apr 9 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) ![Down comforters, pillowtop beds, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/d338fe80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/3c74c93a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/826eec73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily cooked-to-order breakfast](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/9866ab41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Lake City [](https://www.expedia.ca/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) Lake City 7.2/10 Good (701 reviews) "Breakfast included cooked-to order scrambled eggs & sausage." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $88 CA $99 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) ![Individually decorated, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/9948e87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/24283982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/6331cb77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/e71ac0d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-10 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) Lake City 7.0/10 Good (1,002 reviews) "Low cost but worth it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $88 CA $100 total includes taxes & fees Apr 19 - Apr 20 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/d6ac3255.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/46f5353a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/caeee0a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/c2fe5650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 – Lake City, Fl – Medical Center [](https://www.expedia.ca/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) Lake City 8.0/10 Very good (130 reviews) "Dog friendly and price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $76 CA $86 total includes taxes & fees May 3 - May 4 [](https://www.expedia.ca/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) ![Premium bedding, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/c251e287.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/b1f4498a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/62d30ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/cd217d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palms Garden Inn [](https://www.expedia.ca/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) Lake City 7.4/10 Good (602 reviews) "room was clean and the air conditioning worked great would recommend" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) david CA $90 CA $101 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/f86787e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/0820ad86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/8b97268c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Sleeper Sofa](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/2a6fa58f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Blanche [](https://www.expedia.ca/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information) Lake City 9.4/10 Exceptional (179 reviews) "Loved the hotel and the location! The bed was very very soft and the microfiber sheets were thin and hot!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim CA $188 CA $212 total includes taxes & fees Apr 15 - Apr 16 [](https://www.expedia.ca/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information) ![3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/994169e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic House, 2 Bedrooms, Patio, River View | Terrace/patio](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/9fdd625a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Cabin, Resort View | In-room dining](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/c163ad60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Tent](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/ab1e5af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Suwannee River Rendezvous [](https://www.expedia.ca/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information) Mayo 8.8/10 Excellent (26 reviews) "We had a good family getaway and was impressed how the camping experience was . Me and my family had an awesome outdoor experience and we will return again . The people their welcomed you like family and mad the trip and safe " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) amy CA $37 CA $60 total includes taxes & fees Apr 19 - Apr 20 [](https://www.expedia.ca/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/3c8063dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/581d600c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/30e379b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/6eb28891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### < 1 Mi From Suwannee River, Hideaway w/ Lanai [](https://www.expedia.ca/Old-Town-Hotels-1-Mi-From-Suwannee-River.h126526410.Hotel-Information) Old Town 10/10 Exceptional (1 review) "The Air B & B was amazing. The property and the A B & B was awesone, Clean, Quiet and very comfortable. Although some nights got a bit chilly and this property only had AC no heat. We managed just fine. We left it in perfect conditions according to the directions they wanted it left in. Thank you so much and we will be renting again. We also would recommend this to others. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $169 CA $542 total includes taxes & fees Apr 7 - Apr 8 [](https://www.expedia.ca/Old-Town-Hotels-1-Mi-From-Suwannee-River.h126526410.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/4156d709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/737c0544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/6cb67822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/ec822d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard By Marriott Lake City [](https://www.expedia.ca/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) Lake City 9.4/10 Exceptional (229 reviews) "Very nice hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Travis CA $173 CA $194 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/1d4a6615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/2dd8879c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/847fac5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/68371972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Alachua I-75 [](https://www.expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information) Alachua 9.4/10 Exceptional (494 reviews) "Breakfast awesome Parking great Staff awesome " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bryan CA $159 CA $178 total includes taxes & fees Apr 26 - Apr 27 [](https://www.expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds (Walk-In Shower)](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/578d088f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/758be2b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/a1c39a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG [](https://www.expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) Alachua 9.4/10 Exceptional (1,001 reviews) "Great stay, nice area" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $138 CA $155 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/ad8fe69d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Double Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/0b835941.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/016b48da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Lake City [](https://www.expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) Lake City 8.6/10 Excellent (1,003 reviews) "Clean place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $93 CA $105 total includes taxes & fees Apr 20 - Apr 21 [](https://www.expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/72000000/71210000/71205800/71205738/c57ef407.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71210000/71205800/71205738/2ec170cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room | Bathroom](https://images.trvl-media.com/lodging/72000000/71210000/71205800/71205738/3d58aa43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71210000/71205800/71205738/3baf3a16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Regal Inn [](https://www.expedia.ca/Lake-City-Hotels-Regal-Inn.h71205738.Hotel-Information) Lake City 8.6/10 Excellent (574 reviews) "Nice staff, the room was clean and the bed was comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $80 CA $90 total includes taxes & fees Apr 8 - Apr 9 [](https://www.expedia.ca/Lake-City-Hotels-Regal-Inn.h71205738.Hotel-Information) ![Fountain](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/dffd0064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Room](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/cf88e1e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/5794d577.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### BlueGem Motel [](https://www.expedia.ca/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) High Springs 9.2/10 Wonderful (429 reviews) "Wonderful staff nice location clean rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wayne CA $133 CA $150 total includes taxes & fees Apr 8 - Apr 9 [](https://www.expedia.ca/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/42c18c29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/8fa5709a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/86c94896.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-75 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) Lake City 7.6/10 Good (1,002 reviews) "Quiet comfortable and courteous staff. We Had great time!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha CA $88 CA $99 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Suite, Multiple Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/2b2698df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/bb1585dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/1d6290c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/695b0a91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) Lake City 9.6/10 Exceptional (1,001 reviews) "Clean room and facilities with very friendly staff during our entire stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Moriah CA $162 CA $183 total includes taxes & fees May 4 - May 5 [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/fb3e9b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/dc8aa87c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lake City [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) Lake City 9.0/10 Wonderful (1,038 reviews) "Clean room, easy check in/out, friendly staff, friendly staff, simple but delicious breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara CA $144 CA $162 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/0011ea88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/8e94b4a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast on weekdays](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/9112bbc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suite by Wyndham Lake City [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) Lake City 8.8/10 Excellent (1,080 reviews) "Excellent place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donovan CA $143 CA $161 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-17&endDate=2026-04-18®ionId=3000431472&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels.d3000431472.Travel-Guide-Hotels) ## Learn more about O Brien Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities. [See all hotels in O Brien](https://www.expedia.ca/Hotel-Search?startDate=2026-04-17&endDate=2026-04-18&adults=2®ionId=3000431472) ![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top O Brien Hotel Reviews ## Recent Reviews in O Brien ![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg) ### Americas Best Value Inn Lake City 10/10 Excellent "Good breakfast very helpful kind staff" [](https://expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e_y.jpg) ### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy 8/10 Good "The cabin was perfect, though we wish ours was more off the beaten path. The amenities were sufficient for our needs, though it would have been nice to not need to ask for specific items. We were not allowed to use outdoor cookware, only foil over the fire. The stove inside takes FOREVER to heat, so cooking was a bit of a challenge- but still fun! The staff is incredibly friendly and prompt. There is so much to do in the area, though some parks might be closed!" [](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Baymont by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094_y.jpg) ### Baymont by Wyndham Lake City I-75 8/10 Good "Stayed four nights and never had room service, had to take bath towels to front desk to get exchanged for clean ones" [](https://expedia.ca/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ![Fairfield Inn & Suites Lake City](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/8c221c11_y.jpg) ### Fairfield Inn & Suites Lake City 10/10 Excellent "Beautiful room and hotel" [](https://expedia.ca/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) ![Quality Inn Lake City](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/dbe6bb59_y.jpg) ### Quality Inn Lake City 8/10 Good "This hotel was reasonably priced and provided the accommodation that my wife and I desired. Some upgrades were not complete correctly and when I bought this to the attention of the hotel staff they showed appreciation for my report of the situation. I am happy to return for future visits and recommend it to anyone desiring a good place to stay." [](https://expedia.ca/Lake-City-Hotels-Quality-Inn-Lake-City.h484004.Hotel-Information) ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg) ### La Quinta Inn & Suite by Wyndham Lake City 8/10 Good "Friendly staff " [](https://expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 10/10 Excellent "Good" [](https://expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg) ### Tru by Hilton Lake City 8/10 Good "Mattresses could be firmer." [](https://expedia.ca/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Days Inn by Wyndham Lake City I-10](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/9948e87a_y.jpg) ### Days Inn by Wyndham Lake City I-10 10/10 Excellent "Parking was plentiful." [](https://expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ## More cheap stays in O Brien ![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Americas Best Value Inn Lake City 3835 West US Highway 90 Lake City FL CA $93 CA $105 total Apr 20 - Apr 21 includes taxes & fees 8.6/10 Excellent! (1,003 reviews) [](https://expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### La Quinta Inn & Suite by Wyndham Lake City 165NW CALI DRIVE Lake City FL CA $143 CA $161 total Apr 5 - Apr 6 includes taxes & fees 8.8/10 Excellent! (1,080 reviews) [](https://expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Lake City 350 SW Florida Gateway Dr Lake City FL CA $144 CA $162 total Apr 6 - Apr 7 includes taxes & fees 9/10 Wonderful! (1,038 reviews) [](https://expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tru by Hilton Lake City 284 NW Centurion Court Lake City FL CA $152 CA $171 total Apr 12 - Apr 13 includes taxes & fees 9.2/10 Wonderful! (1,001 reviews) [](https://expedia.ca/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Live Oak by IHG 6694 Us Highway 129 Live Oak FL CA $159 CA $175 total Apr 19 - Apr 20 includes taxes & fees 8.4/10 Very Good! (818 reviews) [](https://expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Comfort Suites Lake City](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/2b2698df_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites Lake City 3690 W Us Highway 90 Lake City FL CA $162 CA $183 total May 4 - May 5 includes taxes & fees 9.6/10 Exceptional! (1,001 reviews) [](https://expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ## Hotels in O Brien with star rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 20 properties [](https://expedia.ca/3Star-O-Brien-Hotels.s30-0-d3000431472.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 66 properties [](https://expedia.ca/2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in O Brien? > This area is the main draw for visitors to O'Brien, as it provides direct access to the natural beauty and recreational opportunities of the Suwannee River. You'll find a scattering of accommodations, from holiday rentals to small, independent motels, often with direct riverfront access or just a short drive away. This allows for convenient enjoyment of activities like fishing, kayaking, and boating. > > > Families will find this area particularly appealing due to the easy access to water-based activities. Many properties offer amenities like barbecue areas and space for children to play, making it simple to enjoy the outdoors together. The nearby Spirit of the Suwannee Music Park also hosts various events throughout the year, which can be a fun addition to a family holiday. > > > For couples looking for a relaxed escape, staying by the river offers a peaceful setting. You can enjoy quiet evenings by the water, explore the river's springs, or simply unwind away from city life. ### When is the best time to go to O Brien? > During these periods, the weather is generally mild and pleasant, with comfortable temperatures, making it ideal for enjoying outdoor activities like swimming, fishing, and exploring the natural springs without the intense heat and humidity of summer or the cooler temperatures of winter. The spring also brings blooming wildflowers, adding to the area's natural beauty. > > > For couples looking for a relaxing escape, these shoulder seasons offer a good balance of agreeable weather and fewer crowds compared to peak summer. You'll find it easier to enjoy the tranquility of the Ichetucknee Springs State Park or the Suwannee River without feeling overwhelmed by other visitors. > > > Families travelling with children might also find these times more comfortable for outdoor adventures. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a O Brien hotel booking with Expedia? ### How much is the nightly rate at a O Brien hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Alton Hotels ](https://www.expedia.ca/Alton-Hotels.d553248635975876473.Travel-Guide-Hotels) - [Resorts in Alton ](https://www.expedia.ca/Alton-Resort-Hotels.d553248635975876473-aaResortHotels.Travel-Guide-Accommodation) - [Aparthotels in Bell ](https://www.expedia.ca/Bell-Apart-Hotels.d3000430838-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Bell ](https://www.expedia.ca/Bell-Bed-And-Breakfast.d3000430838-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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