Title: Visit O Brien: Best of O Brien Tourism | Expedia Travel Guide - Expedia.ca [Hotels in O Brien](https://expedia.ca/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.ca/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.ca/O-Brien.d3000431472.Destination-Travel-Guides) # O Brien ## Travel Guide ![Photo by Dr__Vlad](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Dr\_\_Vlad](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg) ## Visit O Brien - O Brien Hotel Deals - Vacation Rentals in O Brien ![Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!](https://images.trvl-media.com/lodging/92000000/91440000/91435900/91435872/c7d330d9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! obrien FL Book a stay at this beach vacation home in O Brien. Enjoy free WiFi, a beach locale, and a fitness center. Popular attractions Wes Skiles Peacock Springs State ... 9.8/10 Exceptional! (30 reviews) Awesome place in a location that is perfect for visiting the springs. Had a great time and would return. Reviewed on Nov 29, 2025 [Get rates](https://expedia.ca/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=91435872&PinnedHotelID=91435872&HadPinnedHotel=true®ionId=3000431472) [](https://expedia.ca/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=91435872&PinnedHotelID=91435872&HadPinnedHotel=true®ionId=3000431472) ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Quinta Inn & Suite by Wyndham Lake City 165NW CALI DRIVE Lake City FL CA $129 CA $145 total Dec 24 - Dec 25 includes taxes & fees Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 8.6/10 Excellent! (1,016 reviews) Nice hotel with friendly staff! Reviewed on Dec 22, 2025 [](https://expedia.ca/Hotel-Search?startDate=24%2F12%2F2025&endDate=25%2F12%2F2025&selected=48281488&PinnedHotelID=48281488&HadPinnedHotel=true®ionId=3000431472) ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 16367 NW 167TH BLVD Alachua FL CA $156 CA $175 total Dec 28 - Dec 29 includes taxes & fees Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ... 9.4/10 Exceptional! (1,001 reviews) Front desk lady was super friendly, efficient and professional. Breakfast was good. Room nice and clean. Very quiet. We really enjoyed our stay. Reviewed on Dec 17, 2025 [](https://expedia.ca/Hotel-Search?startDate=28%2F12%2F2025&endDate=29%2F12%2F2025&selected=22858269&PinnedHotelID=22858269&HadPinnedHotel=true®ionId=3000431472) [See all 347 properties in O Brien](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=3000431472) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!](https://images.trvl-media.com/lodging/92000000/91440000/91435900/91435872/c7d330d9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! obrien FL Book a stay at this beach vacation home in O Brien. Enjoy free WiFi, a beach locale, and a fitness center. Popular attractions Wes Skiles Peacock Springs State ... 9.8/10 Exceptional! (30 reviews) Awesome place in a location that is perfect for visiting the springs. Had a great time and would return. Reviewed on Nov 29, 2025 [](https://expedia.ca/O-Brien-Hotels-Royal-Springs-Riverfront-Retreat.h91435872.Hotel-Information) ![MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY](https://images.trvl-media.com/lodging/36000000/35540000/35530500/35530445/40faca7c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY O'Brien FL Stay at this vacation home in O Brien. Enjoy a garden, laundry facilities, and patios. Popular attractions Wes Skiles Peacock Springs State Park and Telford ... 9.4/10 Exceptional! (59 reviews) A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs! Reviewed on Sep 1, 2025 [](https://expedia.ca/O-Brien-Hotels-Margaritaville-BY-THE-Suwannee-River-Royal-Springs-PET-Friendly.h35530445.Hotel-Information) ![Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/fce767a1_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy 1699 NE Co Rd 337 High Springs FL Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ruth B. Kirby Gilchrist Blue Springs State Park and ... 9.8/10 Exceptional! (153 reviews) Very good, Nice Reviewed on Dec 18, 2025 [](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) [See all properties in O Brien](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000431472&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check O Brien hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-12-23&endDate=2025-12-24)[Dec 23 - Dec 24](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-12-23&endDate=2025-12-24) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-12-24&endDate=2025-12-25)[Dec 24 - Dec 25](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-12-24&endDate=2025-12-25) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=26%2F12%2F2025&endDate=28%2F12%2F2025)[Dec 26 - Dec 28](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=26%2F12%2F2025&endDate=28%2F12%2F2025) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=02%2F01%2F2026&endDate=04%2F01%2F2026)[Jan 2 - Jan 4](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=02%2F01%2F2026&endDate=04%2F01%2F2026) ## Cities near O Brien ![Branford](https://mediaim.expedia.com/destination/9/4d9a2faf5131a38bd633fb715b20c5d3.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Branford ![Photo by Dr__Vlad](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Fort White - Cities near O Brien - Places of interest [Branford](https://expedia.ca/Branford.dx6188028)[Fort White](https://expedia.ca/Fort-White.dx6286968) - [Ruth B. Kirby Gilchrist Blue Springs State Park ](https://expedia.ca/Ruth-B-Kirby-Gilchrist-Blue-Springs-State-Park-High-Springs.d553248621532654125.Vacation-Attraction) - [Suwannee River State Park ](https://expedia.ca/Suwannee-River-State-Park-Florida.d6128386.Vacation-Attraction) - [Bob's River Place ](https://expedia.ca/Bobs-River-Place-Old-Town.d553248633992473977.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app