Title: Visit O Brien: Best of O Brien Tourism | Expedia Travel Guide - Expedia.ca [Hotels in O Brien](https://expedia.ca/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.ca/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.ca/O-Brien.d3000431472.Destination-Travel-Guides) # O Brien ## Travel Guide ![Photo by Dr__Vlad](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Dr__Vlad](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg) ## Visit O Brien - O Brien Hotel Deals - Vacation Rentals in O Brien ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 16367 NW 167TH BLVD, Alachua, FL CA $138 CA $156 total Oct 13 - Oct 14 includes taxes & fees Stay at this 3.5-star business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.4/10 Exceptional! (1,006 reviews) "Property was easily accessable off I-75. Plenty of parking. Clean room that was large and comfortable." Reviewed on Oct 6, 2025 [](https://expedia.ca/Hotel-Search?startDate=13%2F10%2F2025&endDate=14%2F10%2F2025&selected=22858269&PinnedHotelID=22858269&HadPinnedHotel=true®ionId=3000431472) ![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Lake City 350 SW Florida Gateway Dr, Lake City, FL Fully refundableReserve now, pay when you stay CA $113 CA $127 total Oct 15 - Oct 16 includes taxes & fees Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9/10 Wonderful! (1,003 reviews) "Nice, clean propertry" Reviewed on Oct 3, 2025 [](https://expedia.ca/Hotel-Search?startDate=15%2F10%2F2025&endDate=16%2F10%2F2025&selected=901396&PinnedHotelID=901396&HadPinnedHotel=true®ionId=3000431472) ![Postcard Cabins Gilchrist Springs](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/83bdf0c4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Postcard Cabins Gilchrist Springs 1699 NE Co Rd 337, High Springs, FL Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ... 9.8/10 Exceptional! (121 reviews) "Great place" Reviewed on Oct 4, 2025 [Get rates](https://expedia.ca/Hotel-Search?startDate=23%2F10%2F2025&endDate=24%2F10%2F2025&selected=110494372&PinnedHotelID=110494372&HadPinnedHotel=true®ionId=3000431472) [](https://expedia.ca/Hotel-Search?startDate=23%2F10%2F2025&endDate=24%2F10%2F2025&selected=110494372&PinnedHotelID=110494372&HadPinnedHotel=true®ionId=3000431472) [See all 330 properties in O Brien](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=3000431472) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY](https://images.trvl-media.com/lodging/36000000/35540000/35530500/35530445/40faca7c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY O'Brien Stay at this vacation home in O Brien. Enjoy a garden, laundry facilities, and patios. Popular attractions Wes Skiles Peacock Springs State Park and Telford ... 9.4/10 Exceptional! (58 reviews) "A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!" Reviewed on Sep 1, 2025 [](https://expedia.ca/O-Brien-Hotels-Margaritaville-BY-THE-Suwannee-River-Royal-Springs-PET-Friendly.h35530445.Hotel-Information) ![Postcard Cabins Gilchrist Springs](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/83bdf0c4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Postcard Cabins Gilchrist Springs 1699 NE Co Rd 337, High Springs, FL Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ... 9.8/10 Exceptional! (121 reviews) "Great place" Reviewed on Oct 4, 2025 [](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Nature + Music + Town - Cozy Farmhouse Retreat](https://images.trvl-media.com/lodging/46000000/45650000/45647900/45647893/4cb41f94_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Nature + Music + Town - Cozy Farmhouse Retreat Live Oak Stay at this vacation home in Live Oak. Enjoy laundry facilities, patios, and an in-room coffeemaker. Popular attractions Suwannee County Historical Museum and ... 10/10 Exceptional! (19 reviews) "The home was equipped well. Everything was perfect. Thank you for the pleasant stay." Reviewed on Sep 29, 2025 [](https://expedia.ca/Live-Oak-Hotels-Nature-Music-Town-Cozy-Farmhouse-Retreat.h45647893.Hotel-Information) [See all properties in O Brien](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000431472&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check O Brien hotel availability [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-09&endDate=2025-10-10) [Tonight](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-09&endDate=2025-10-10) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-09&endDate=2025-10-10) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-09&endDate=2025-10-10)[Oct 9 - Oct 10](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-09&endDate=2025-10-10) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-10&endDate=2025-10-11) [Tomorrow night](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-10&endDate=2025-10-11) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-10&endDate=2025-10-11) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-10&endDate=2025-10-11)[Oct 10 - Oct 11](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=2025-10-10&endDate=2025-10-11) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=10%2F10%2F2025&endDate=12%2F10%2F2025) [This weekend](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=10%2F10%2F2025&endDate=12%2F10%2F2025) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=10%2F10%2F2025&endDate=12%2F10%2F2025) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=10%2F10%2F2025&endDate=12%2F10%2F2025)[Oct 10 - Oct 12](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=10%2F10%2F2025&endDate=12%2F10%2F2025) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=17%2F10%2F2025&endDate=19%2F10%2F2025) [Next weekend](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=17%2F10%2F2025&endDate=19%2F10%2F2025) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=17%2F10%2F2025&endDate=19%2F10%2F2025) [](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=17%2F10%2F2025&endDate=19%2F10%2F2025)[Oct 17 - Oct 19](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431472&startDate=17%2F10%2F2025&endDate=19%2F10%2F2025) ## Cities near O Brien ![Branford](https://mediaim.expedia.com/destination/9/4d9a2faf5131a38bd633fb715b20c5d3.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Branford [](https://expedia.ca/Branford.dx6188028) ![Photo by Dr__Vlad](https://mediaim.expedia.com/destination/2/7295ff71ceef7b23948ecc12e5c78e3b.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Fort White [](https://expedia.ca/Fort-White.dx6286968) - Cities near O Brien - Places of interest [Branford](https://expedia.ca/Branford.dx6188028)[Fort White](https://expedia.ca/Fort-White.dx6286968) - [Ruth B. Kirby Gilchrist Blue Springs State Park](https://expedia.ca/Ruth-B-Kirby-Gilchrist-Blue-Springs-State-Park-High-Springs.d553248621532654125.Vacation-Attraction) - [Suwannee River State Park](https://expedia.ca/Suwannee-River-State-Park-Florida.d6128386.Vacation-Attraction) - [Bob's River Place](https://expedia.ca/Bobs-River-Place-Old-Town.d553248633992473977.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)