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Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22
In one month
Dec 4 - Dec 6
In two months
Jan 1 - Jan 3
No exact matches found, but these alternatives could be just right

Recommended hotels in O Brien

A covered porch with wooden railings, a table, and four chairs.

1. Suwannee Music Park about 30 mins away. Royal Springs across the street.

Suwannee Music Park about 30 mins away. Royal Springs across the street.
O'Brien
9.6 out of 10, Exceptional, (7 reviews)
"Had a great time there for the holiday weekend.."
United States
Karen L.
The price is CA $197
CA $485 total
includes taxes & fees
Nov 14 - Nov 15
Suwannee Music Park about 30 mins away. Royal Springs across the street.
A wooden deck overlooking a calm lake with two glasses of red wine.

2. MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
O'Brien
9.4 out of 10, Exceptional, (60 reviews)
"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"
United States
Heather H.
The price is CA $179
CA $464 total
includes taxes & fees
Nov 9 - Nov 10
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
A spacious living area with a grey sofa, a coffee table, and a TV stand.

3. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,131 reviews)
"Staff was helpful, room was clean and the breakfast was amazing."
United States
Melissa
The price is CA $113
CA $127 total
includes taxes & fees
Dec 1 - Dec 2
Best Western Plus Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

4. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"Overall great stay!"
United States
Jim
The price is CA $135
CA $152 total
includes taxes & fees
Dec 6 - Dec 7
Comfort Suites Lake City
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

5. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,004 reviews)
"Clean and well maintained hotel"
United States
Carlos
The price is CA $131
CA $148 total
includes taxes & fees
Dec 6 - Dec 7
Tru by Hilton Lake City
Lobby

6. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,003 reviews)
"I have stayed here several times. Staff is at least very friendly and accommodating properties very clean. We enjoyed our stay."
United States
Eileen
The price is CA $137
CA $154 total
includes taxes & fees
Dec 6 - Dec 7
Hampton Inn & Suites Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

7. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
"Stayed here on the way to Disney so wouldn't have to drive so far one way for the family. It was a nice place to stay."
United States
Anthony
The price is CA $131
CA $147 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

8. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,202 reviews)
"Very nice visit, very clean room, excellent staff, great breakfast, easy parking"
United States
Emory
The price is CA $132
CA $149 total
includes taxes & fees
Dec 2 - Dec 3
La Quinta Inn & Suite by Wyndham Lake City
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

9. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (765 reviews)
"Rooms where very clean and staff was so helpful and nice."
United States
Scott
The price is CA $86
CA $97 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Lake City
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

10. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,000 reviews)
"Very nice hotel!"
United States
Mary
The price is CA $97
CA $109 total
includes taxes & fees
Dec 7 - Dec 8
Quality Inn Lake City
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

11. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,007 reviews)
"This is a great hotel for the price. Clean, room was small. Close to restaurants and parking lot is well lite."
United States
Brenda
The price is CA $100
CA $113 total
includes taxes & fees
Nov 9 - Nov 10
Americas Best Value Inn Lake City
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

12. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (314 reviews)
"Nice overnight stay."
United States
Zanza
The price is CA $164
CA $185 total
includes taxes & fees
Nov 15 - Nov 16
Courtyard By Marriott Lake City
A bedroom with a bed, a desk, a chair, and a ceiling fan.

13. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (141 reviews)
"Clean room"
United States
Nazare
The price is CA $120
CA $130 total
includes taxes & fees
Dec 8 - Dec 9
Cindys Motel
A spacious lobby with multiple seating areas, a bar, and a large window with a view.

14. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
"Next time I am needing motel in Lake City, will plan to stay at this location."
United States
William
The price is CA $134
CA $151 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn & Suites Lake City by IHG
A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

15. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
"Easy parking room clean"
United States
Pennee
The price is CA $82
CA $92 total
includes taxes & fees
Nov 9 - Nov 10
Baymont by Wyndham Lake City I-75
A hotel room with two beds, a blue wall, and a window with curtains.

16. Gateway Inn

Gateway Inn
2.5 star property
Lake City
7.8 out of 10, Good, (212 reviews)
"Nice modern, clean hotel room"
United States
Karen
The price is CA $68
CA $77 total
includes taxes & fees
Nov 9 - Nov 10
Gateway Inn
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

17. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (833 reviews)
"Big, clean room and the staff was very friendly"
United States
Laurie
The price is CA $168
CA $189 total
includes taxes & fees
Nov 22 - Nov 23
Home2 Suites by Hilton Lake City
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.

18. Regal Inn

Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (620 reviews)
"This is the second time I’ve stayed at this hotel. Convenient to restaurants and gas stations. Look forward to staying again."
United States
Gerardo
The price is CA $88
CA $99 total
includes taxes & fees
Nov 9 - Nov 10
Regal Inn
A reception area with a counter, seating, and a fireplace.

19. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (899 reviews)
"Lee and all staff were so wonderful. Rooms clean-great stay"
United States
KRISTEN
The price is CA $140
CA $154 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express & Suites Live Oak by IHG
A hotel room with two beds, a desk, a chair, a lamp, and a view of the outdoors.

20. Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.0 out of 10, Good, (600 reviews)
"Everything good"
United States
Guillermo
The price is CA $118
CA $130 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn & Suites Live Oak I-10 Exit 283
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top reviews in O Brien

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
Comfort Suites Lake City

Comfort Suites Lake City

Comfort Suites Lake City
Lake City

10/10 Excellent

Excellent service and very friendly staff
Canada
Nina
Reviewed August 21, 2025
Comfort Suites Lake City

Frequently Asked Questions

What is the top aparthotel for my visit to O Brien?

Located 9.9 mi (15.9 km) from O Brien, Cozy hotel suite in peaceful Mayo with AC, WiFi, fitness room is a favorite aparthotel to consider.

How many aparthotels are there in O Brien?

On Expedia, you'll find 9 hotels and other lodging options in O Brien. Though you won't find many aparthotels, we can suggest places to stay that are similar such as a condo or apartment.

What should I see and do in O Brien?

Suwannee River and Ichetucknee River are a couple of lovely local spots to get outside and enjoy nature. In the larger area, you’ll find Ichetucknee Springs State Park and Lafayette Blue Springs State Park.

What is an aparthotel?

An aparthotel is a hybrid hotel and apartment, with the amenities of a traditional hotel, and more space and privacy found in an apartment. By booking an aparthotel, you can book a longer stay and absorb more of the local color in O Brien. Enjoy home cooking in the private kitchen and having extra space to spread out while you're in town.

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