Mill Creek Vacation Rentals

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Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Mill Creek vacation rentals

A living room with a TV, a fireplace, a sofa, and wall art.

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $115
CA $143 total
includes taxes & fees
Nov 14 - Nov 15
Little Blue Cottage on Spanish
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

2. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
The price is CA $160
CA $188 total
includes taxes & fees
Nov 15 - Nov 16
Cozy cabins on beautiful Horseshoe Lake
A rustic wooden house with a porch and a fenced field in the background.

3. Shawnee Wine Trail Farm Stay

Shawnee Wine Trail Farm Stay
Makanda
10.0 out of 10, Exceptional, (26 reviews)
"It was a cute little place to stay. Very relaxing."
United States
Sherri R.
The price is CA $67
CA $153 total
includes taxes & fees
Nov 16 - Nov 17
Shawnee Wine Trail Farm Stay
A wooden deck with a table and chairs, surrounded by a wooden railing, overlooking a grassy area with trees.

4. Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (432 reviews)
"Beautiful quaint cabin! Had everything you could need. Would definitely recommend to anyone looking for a nice place to stay."
United States
Brandon
The price is CA $167
CA $296 total
includes taxes & fees
Nov 15 - Nov 16
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
A calm lake with a dock and a small boat.

5. Charming cabin overlooking Lake Acre

Charming cabin overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (107 reviews)
"The cottage was clean, spacious, had 2 bathrooms (which is uncommon for small cabins). It was very well stocked with kitchen items, and the bath towels were awesome, the bed was very nice. It was peaceful and beautiful. The hostess, Suzie was easy to contact and helpful when we had a question upon checking ìn. I would recommend this place and would stay again if we are in the area!"
United States
Teresa
The price is CA $214
CA $370 total
includes taxes & fees
Dec 1 - Dec 2
Charming cabin overlooking Lake Acre
A wooden cabinet with a microwave, coffee maker, and plates.

6. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (30 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is CA $146
CA $234 total
includes taxes & fees
Nov 24 - Nov 25
Cozy and Updated Farmhouse with King Suite
A wooden-paneled room with a framed picture of dogs, a Keurig coffee maker, a tray with cups and a tissue box.

7. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (32 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is CA $160
CA $188 total
includes taxes & fees
Nov 15 - Nov 16
The Rested Duck Mallard Room
A brick building with a sign reading "1898 Guesthouse".

8. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (15 reviews)
"The place was nice and clean and the hosts were great. Would definitely stay there again!"
United States
Katlynn R.
The price is CA $196
CA $391 total
includes taxes & fees
Nov 25 - Nov 26
Stunning 2 bedroom in town, close to Shawnee National Forest
A wooden deck with a potted plant and a table and chairs.

9. Maple Ridge Cabin at Panther's Rest

Maple Ridge Cabin at Panther's Rest
Makanda
9.6 out of 10, Exceptional, (35 reviews)
"We loved our stay and will definitely be back! "
United States
Ashley M.
The price is CA $103
CA $203 total
includes taxes & fees
Nov 18 - Nov 19
Maple Ridge Cabin at Panther's Rest
An outdoor seating area with two Adirondack chairs and a fire pit, surrounded by a gravel circle on a grassy field with a forest in the background.

10. Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
Anna
10.0 out of 10, Exceptional, (16 reviews)
"We enjoyed our stay here. The beds were very comfortable and it was close to all of the wineries along the wine trail."
United States
Kristi H.
The price is CA $174
CA $365 total
includes taxes & fees
Nov 17 - Nov 18
Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
A triangular wooden cabin with a staircase leading up to a door, surrounded by trees.

11. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (40 reviews)
"great getaway. tucked away in the woods. beautiful scenery"
United States
Crystal R.
The price is CA $200
CA $293 total
includes taxes & fees
Nov 16 - Nov 17
Peaceful secluded cabin located near Horseshoe Lake
A window with a view of a sunset over a landscape.

12. Crossview Cottage - Direct view of Bald Knob Cross

Crossview Cottage - Direct view of Bald Knob Cross
Alto Pass
10.0 out of 10, Exceptional, (7 reviews)
"Host was timely with communications, the place was perfect for us and our dog, all the amenities were on site, it was easy to access and come and go from Alto Pass."
United States
Shea
The price is CA $164
CA $200 total
includes taxes & fees
Nov 16 - Nov 17
Crossview Cottage - Direct view of Bald Knob Cross
A modern interior with a large glass door leading to an outdoor area, a marble floor, and a small round table with a vase.

13. Peach Tree Inn, downtown Cobden

Peach Tree Inn, downtown Cobden
Cobden
10.0 out of 10, Exceptional, (3 reviews)
"Amazing place to stay. Excellent location, beautiful rooms and accommodation and the host was so responsive. We will definitely be back!"
United States
Rebecca L.
The price is CA $265
CA $316 total
includes taxes & fees
Nov 16 - Nov 17
Peach Tree Inn, downtown Cobden
A white building with a grey roof, two garage doors, and exterior lighting fixtures.

14. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $178
CA $271 total
includes taxes & fees
Nov 19 - Nov 20
The Cottage, Rusted Route Farms
A modern kitchen with grey cabinets, a wooden countertop, a coffee machine, and a welcome sign on the wall.

15. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is CA $151
CA $261 total
includes taxes & fees
Dec 7 - Dec 8
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
A room with a pool table, a sofa, and a dining table with chairs.

16. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (6 reviews)
"The location is lovely and peaceful. The cabin is clean, comfortable and relaxing. We enjoyed the pool table and ping pong."
United States
Michelle U.
The price is CA $257
CA $344 total
includes taxes & fees
Nov 22 - Nov 23
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
A wooden deck with a chair and a sign that reads "COME SIT on the PORCH".

17. Secluded treehouse with indoor fireplace

Secluded treehouse with indoor fireplace
Makanda
10.0 out of 10, Exceptional, (31 reviews)
"Very nice place. We enjoyed it."
United States
Gregory M.
The price is CA $171
CA $264 total
includes taxes & fees
Nov 18 - Nov 19
Secluded treehouse with indoor fireplace
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

18. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is CA $221
CA $308 total
includes taxes & fees
Nov 14 - Nov 15
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
A two-story house with a large front yard, a swimming pool, and a fenced backyard.

19. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $255
CA $431 total
includes taxes & fees
Nov 15 - Nov 16
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

20. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"Very cute, especially because it's pet friendly! Currently building additional structures on site but appears almost complete and still a beautiful setting and property."
United States
Elizabeth K.
The price is CA $238
CA $330 total
includes taxes & fees
Nov 14 - Nov 15
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mill Creek Hotel Reviews

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau

10/10 Excellent

Friendly staff, clean room. Great food. Highly recommend this hotel.
Canada
Sareh
Reviewed August 9, 2026
Drury Plaza Hotel Cape Girardeau Conference Center

Find out more about Mill Creek

Everything you need to know about Mill Creek vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mill Creek vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mill Creek vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Mill Creek vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Mill Creek. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Mill Creek vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Mill Creek vacation rentals we have selected for you start as low as CA $67 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Mill Creek rentals

At Expedia, we put the best Mill Creek vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Mill Creek rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mill Creek vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mill Creek. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find a vacation rental in Mill Creek?

Yes, there are vacation rentals near the most popular local attractions in Mill Creek, or you can select a more remote option if you want a relaxing place to stay.

What's the top vacation rental that Mill Creek has to offer?

* On the Wine Trail * Hot Tub * Wi-Fi *: This vacation home rental near Mill Creek is located on a lake and has a patio, a hot tub, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave.

What can I see and do in Mill Creek?

While exploring the area, visit family-friendly sights like Henry N Barkhausen Cache River Wetlands Center, or get outside and enjoy nature at Lower Cache River Access Area. In the larger area, you’ll find Trail of Tears State Park and Century Casino & Hotel Cape Girardeau.

What are vacation rentals like in Mill Creek?

Vacation rentals are private accommodations you can stay in for a few days or a quick weekend in Mill Creek. Vacation rentals offer amenities such as kitchens and laundry facilities so you'll have everything you need. If you're concerned about cleanliness, a vacation rental can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for small groups.