Mayo Clinic Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Holiday Package Deals in Mayo Clinic
Price found within the past 48 hours. Click for updated prices.
Westgate Painted Mountain Golf Resort
Falcon Field Area
CA $723
per person
Oct 12 - Oct 17
found 7 hours ago
Roundtrip flight included
Calgary (YYC) to Phoenix (PHX)
8.4/10 Very good! (1,003 reviews)
The only real issue I had was the noise coming from the adjacent suite. The door between the rooms is just a standard room door. I could hear the neighbors up very early and prepping everything in their kitchen. Other than that, everything was great.
Reviewed on Aug 11, 2026
Mountain Shadows Resort Scottsdale
CA $2,134
per person
Oct 22 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEA) to Phoenix (PHX)
9.8/10 Exceptional! (1,143 reviews)
Great staff that were pleasant and accommodating. Lovely large pool. Very hot time of year and our air conditioning made it comfortable but room temp never made it to our setting (70).
Reviewed on Aug 9, 2026
Scottsdale Camelback Resort
CA $1,299
per person
Oct 22 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEA) to Phoenix (PHX)
9/10 Wonderful! (1,562 reviews)
Great stay in a large spacious two bedroom villa - thank you for the upgrade and accommodating my request to be located in a quieter area of the resort.
Quintessential and tranquil Arizona experience with great views of Camelback mountain.
Reviewed on Aug 11, 2026
Omni Scottsdale Resort & Spa at Montelucia
Paradise Hills
CA $2,304
per person
Oct 11 - Oct 16
found 11 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
9.4/10 Exceptional! (1,105 reviews)
The shower was very hot with no cold water. The fridge made a loud noise which kept me up most of the night. Totally overpriced for what we got
Reviewed on Aug 10, 2026
Where to stay in Mayo Clinic
Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix
3 out of top 10 points of interest in this area
A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.
Rio Verde Foothills
If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Golf Club Scottsdale and Tom's Thumb Trail.
Old Town
Old Town is known for its popular shops, and you can see some sights in the area like Scottsdale Waterfront and Western Spirit: Scottsdale's Museum of the West.
Camelback East
Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.
The Islands
While there might not be top attractions in The Islands, you can explore the larger area and discover places like Gilbert Civic Center and Gilbert Farmers Market.
Mayo Clinic Hotel Deals
Hilton Phoenix Tapatio Cliffs Resort
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
CA $147
CA $228 total
Sep 1 - Sep 2
includes taxes & fees
8.8/10 Excellent! (2,971 reviews)
"We spent 2 days poolside all the staff was wonderful!! Very clean room."
Reviewed on Aug 10, 2026
FOUNDRE Phoenix
1100 N Central Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
CA $119
CA $173 total
Aug 12 - Aug 13
includes taxes & fees
Talking Stick Resort
9800 E. Talking Stick Way Scottsdale AZ
CA $166
CA $229 total
Aug 20 - Aug 21
includes taxes & fees
9.4/10 Exceptional! (5,048 reviews)
"Beautiful stay"
Reviewed on Aug 11, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Mayo Clinic vacation package cost?
Starting from as low as CA $723, a package is your gateway to low-priced travel. Customize your Mayo Clinic trip by choosing from our extensive range of hotels, flights and rental cars.
How do I get a cheap travel package to Mayo Clinic?
Our Mayo Clinic vacation packages promise plenty of savings for the savvy globetrotter. For the best deals, simply combine your flights, hotels and activities into an affordable package. But low prices are just the beginning of your next unforgettable adventure. Book with Expedia and and you'll have over 550 airlines and 1,000,000 properties throughout the world to pick from. No matter your budget or style, there's a vacation package that's perfect for you.
Where should I stay in Mayo Clinic?
Cross Tournament Players Club of Scottsdale off your must-see list and then stay right near it. Soak up the exciting vibe around this terrific attraction and drop by whenever the mood strikes!
What are the top hotels in Mayo Clinic?
Whether you plan to stay for a night or a week in Mayo Clinic, you'll get a great night's rest at Sonesta Select Scottsdale at Mayo Clinic Campus. This option is popular with plenty of travelers.
How far in advance should I book my Mayo Clinic vacation?
Search Expedia to compare international flights as early as possible. In most cases, you can purchase a seat up to 12 months prior to departure. If it's too early for your preferred carrier, or you have to book last minute, don't despair. Cheap fares to Mayo Clinic sometimes occur within weeks of departure.
What does an Expedia Mayo Clinic travel package include?
It all depends on what sort of trip you have in the works. Mayo Clinic vacation deals can include car rentals, hotels and flights. You can mix and match to find the travel package that suits your style and budget. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Mayo Clinic travel package?
When you book your flights, hotels and car rentals together, you'll walk away with awesome discounts. Whether you're planning a beach break in a villa or want to stay in a fancy hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Mayo Clinic Expedia vacation package?
You can, and with over 550 airlines to choose from all over the world, you've got lots of choice. Take a look at the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mayo Clinic vacation package?
You sure can, and we'll help you every step of the way. You may be able to cancel and rebook your Mayo Clinic vacation package at no cost if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, have a look at our Customer Service Portal for further information.
Things to do
SEA LIFE Arizona Aquarium Tickets
CA $29
per adult
84% of travellers recommend
Arizona Diamondbacks Baseball Game Ticket at Chase Field
CA $42
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.