A storefront with a sign reading "The Beach Club" and various clothing items displayed in the window.

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Oct 30 - Nov 1
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Our top choices for Main Street Hyannis hotels

A two-story hotel with a curved facade, a balcony, and a sign indicating the lobby.

1. Hyannis Harbor Hotel

Hyannis Harbor Hotel
3.5 star property
0.6 km from Main Street Hyannis
8.2 out of 10, Very good, (1,005 reviews)
"Great location, staff was extremely helpful"
United States
N.
The price is CA $175
CA $220 total
includes taxes & fees
Nov 1 - Nov 2
Hyannis Harbor Hotel
A multi-story hotel with balconies, a flat roof, and a clear sky.

2. Hyannis Travel Inn

Hyannis Travel Inn
2.5 star property
0.2 km from Main Street Hyannis
9.6 out of 10, Exceptional, (1,023 reviews)
"Great property, convenient location and helpful staff."
United States
Colleen
The price is CA $139
CA $159 total
includes taxes & fees
Oct 29 - Oct 30
Hyannis Travel Inn
A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.

3. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel
2.5 star property
0.3 km from Main Street Hyannis
9.0 out of 10, Wonderful, (193 reviews)
"Very nice place and great location to explore the town."
United States
Holly
The price is CA $178
CA $204 total
includes taxes & fees
Nov 19 - Nov 20
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
A long dining table with chairs, a kitchen area, and a large window.

4. Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
2.5 star property
0.3 km from Main Street Hyannis
8.2 out of 10, Very good, (1,000 reviews)
"Good breakfast. Indoor pool and spa were nice."
United States
darrell
The price is CA $142
CA $162 total
includes taxes & fees
Nov 23 - Nov 24
Comfort Inn Hyannis - Cape Cod
A hotel room with a large bed, a chair, a table, and a window with curtains.

5. SeaCoast Inn

SeaCoast Inn
2.0 star property
0.1 km from Main Street Hyannis
9.0 out of 10, Wonderful, (903 reviews)
"Nice place to stay."
United States
Sue
SeaCoast Inn
An indoor swimming pool with a brick wall, a white table with chairs, and a large window.

6. Courtyard Resort

Courtyard Resort
2.0 star property
0.3 km from Main Street Hyannis
8.6 out of 10, Excellent, (162 reviews)
"Had a great stay. Very clean and smells so nice. Staff was wonderful. Will stay again"
United States
chris
The price is CA $177
CA $202 total
includes taxes & fees
Nov 9 - Nov 10
Courtyard Resort
A covered outdoor seating area with wicker furniture and a glass-top table.

7. Cape Cod Harbor House Inn

Cape Cod Harbor House Inn
2.5 star property
0.4 km from Main Street Hyannis
9.2 out of 10, Wonderful, (349 reviews)
"Room was clean, staff particularly helpful, parking on site, convenient to restaurants , beach , and stores. Would definitely stay here again."
United States
Olivia
Cape Cod Harbor House Inn
A marina with boats docked, a wooden pier, and residential buildings in the background.

8. Cape Cod Inn

Cape Cod Inn
2.0 star property
0.2 km from Main Street Hyannis
8.6 out of 10, Excellent, (585 reviews)
"All around great experience! I highly recommend this location to someone who wants to go out and enjoy what the Cape has to offer."
United States
Ian
Cape Cod Inn
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.

9. Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
0.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (1,001 reviews)
"Very nice stay with everything we needed. Excellent attention to detail. Great breakfast."
United States
Anita
The price is CA $201
CA $270 total
includes taxes & fees
Oct 29 - Oct 30
Anchor In Distinctive Waterfront Lodging
An indoor swimming pool with a covered area, poolside chairs, and a table.

10. Americas Best Value Inn & Suites Hyannis Cape Cod

Americas Best Value Inn & Suites Hyannis Cape Cod
2.0 star property
0.5 km from Main Street Hyannis
8.0 out of 10, Very good, (1,005 reviews)
"America's Best Value Inn"
United States
Linda
Americas Best Value Inn & Suites Hyannis Cape Cod
A coastal scene with a lighthouse, a large house, and boats on the water.

11. Ocean Street Inn on Hyannis Harbor

Ocean Street Inn on Hyannis Harbor
2.0 star property
0.4 km from Main Street Hyannis
7.0 out of 10, Good, (892 reviews)
"Great room and got to use the pool at the main hotel. Great stay."
United States
Richard
Ocean Street Inn on Hyannis Harbor
An indoor water park with slides, a pirate-themed ship, and a sign reading "Pirate Bay".

12. Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod
4.0 star property
3.3 km from Main Street Hyannis
8.6 out of 10, Excellent, (802 reviews)
"Amazing place."
United States
Izaura
The price is CA $214
CA $325 total
includes taxes & fees
Nov 2 - Nov 3
Margaritaville Resort Cape Cod
An outdoor patio with round tables and chairs, a fire pit, and a covered seating area with string lights.

13. Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
0.9 km from Main Street Hyannis
8.4 out of 10, Very good, (953 reviews)
"Great stay"
Canada
Tammie
The price is CA $178
CA $204 total
includes taxes & fees
Nov 6 - Nov 7
Doubletree by Hilton Cape Cod - Hyannis
A spacious living area with a checkered floor, a wooden staircase, a sofa set, a television, and a potted plant.

14. Hyannis Plaza Hotel

Hyannis Plaza Hotel
2.5 star property
0.9 km from Main Street Hyannis
7.2 out of 10, Good, (1,000 reviews)
"The hotel was excellent and the area was amazing I loved it staff was friendly and help full I definitely will be going back"
United States
Teewonda
The price is CA $122
CA $154 total
includes taxes & fees
Nov 1 - Nov 2
Hyannis Plaza Hotel
An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.

15. Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,600 reviews)
"We had a great stay!"
United States
Lynn
The price is CA $125
CA $162 total
includes taxes & fees
Nov 8 - Nov 9
Bayside Resort Hotel
A restaurant with outdoor seating, string lights, and a decorative wall.

16. Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
4.0 star property
1.9 km from Main Street Hyannis
9.2 out of 10, Wonderful, (396 reviews)
"Wonderful stay in delightful hotel. Grounds were immaculate and staff was extremely helpful and welcoming."
United States
Melissa
The price is CA $146
CA $173 total
includes taxes & fees
Nov 13 - Nov 14
Uncommoner Hotel by Reverie Boutique Collection
A neatly arranged bedroom with a large bed, a bedside table, a chair, a TV mounted on the wall, and a window with blinds.

17. Sea Street Inn

Sea Street Inn
4.0 star property
1.5 km from Main Street Hyannis
9.8 out of 10, Exceptional, (47 reviews)
"Wonderful stay. Great communication. Outstanding breakfast."
United States
John
The price is CA $371
CA $424 total
includes taxes & fees
Nov 20 - Nov 21
Sea Street Inn
A hotel room with a sofa, a dining table with chairs, a desk with a chair, and large windows with curtains.

18. Relax Inn Cape Cod

Relax Inn Cape Cod
2.0 star property
1.4 km from Main Street Hyannis
6.4 out of 10, (822 reviews)
"This is your basic motel, nothing fancy. It's clean, quite and the staff is very friendly and helpful."
United States
Kevin
The price is CA $107
CA $122 total
includes taxes & fees
Nov 1 - Nov 2
Relax Inn Cape Cod
A hotel room with two beige sofas, a glass coffee table, and a flat-screen TV mounted on the wall.

19. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area
2.0 star property
1.5 km from Main Street Hyannis
7.0 out of 10, Good, (1,003 reviews)
"Good location and real clean All good"
United States
Eddy
The price is CA $104
CA $119 total
includes taxes & fees
Oct 29 - Oct 30
Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Main Street Hyannis

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A multi-story hotel with balconies, a flat roof, and a clear sky.
Hyannis Travel Inn
2.5 star property
9.6
Exceptional
1,023 reviews
View
A neatly arranged bedroom with a large bed, a bedside table, a chair, a TV mounted on the wall, and a window with blinds.
Sea Street Inn
4.0 star property
9.8
Exceptional
47 reviews
View
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.
Anchor In Distinctive Waterfront Lodging
3.0 star property
9.4
Exceptional
1,001 reviews
View
A restaurant with outdoor seating, string lights, and a decorative wall.
Uncommoner Hotel by Reverie Boutique Collection
4.0 star property
9.2
Wonderful
396 reviews
View
A pool area with lounge chairs and flags.
The Cove at Yarmouth by Westgate Resorts
3.0 star property
9.2
Wonderful
270 reviews
View

Top Main Street Hyannis Hotel Reviews

Sunbird Cape Cod Resort

Sunbird Cape Cod Resort

8/10 Good
"Room was OK. It was clean and comfortable. Missed breakfast one day due to a power outage, but that wasn’t their fault."
James 2-night trip
Posted less than an hour ago
Sunbird Cape Cod Resort

Other attractions near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)
Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.
See properties

Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, check out the 197 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Hyannis Travel Inn is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include Hyannis Harbor Hotel and Hyannis Plaza Hotel.
How many hotels can I expect to find close to Main Street Hyannis?
Expedia has 197 hotels and other accommodations within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view top deals close to Main Street Hyannis.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Centerville Historical Museum, and Edward Gorey House feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse, and West Parish Meetinghouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Veterans Memorial Park, and Dennis Pond Conservation Area are peaceful spots to stop and take in some fresh air.

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