Title: Best Hotels Near Main Street Hyannis, Hyannis from CA $110 | Expedia.ca [Hyannis Travel Guide](https://expedia.ca/Hyannis.dx1544)[Vacation Rentals in Hyannis](https://expedia.ca/Hyannis-Vacation-Rentals.d1544.Travel-Guide-VacationRentals)[Flights to Hyannis](https://expedia.ca/Cheap-Flights-To-Hyannis.d1544.Travel-Guide-Flights)[Things to do in Hyannis](https://expedia.ca/Things-To-Do-In-Hyannis.d1544.Travel-Guide-Activities)[Main Street Hyannis Car Rentals](https://expedia.ca/Car-Rentals-In-Main-Street-Hyannis.d6287458.Car-Rental-Guide)[Main Street Hyannis Vacations](https://expedia.ca/Main-Street-Hyannis-Hyannis.d6287458.Vacation-Attraction) ![Main Street Hyannis featuring street scenes as well as a couple](https://images.trvl-media.com/place/6287458/f083813a-eac6-4b18-a763-a901fa1ed4e5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels near Main Street Hyannis, Hyannis from CA $110 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Top Hotels Close to Main Street Hyannis ![Exterior](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/fe11d49f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/8b9d0245.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, Multiple Beds](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/2c353cdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/3ac160a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Travel Inn 0.2 km from Main Street Hyannis 9.6/10 Exceptional (1005) "Wonderful stay. Looking forward to our next visit!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $139 CA $159 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Travel-Inn.h1379109.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/7438dff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/6d244f7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 2 Queen Beds, Harbour View | Living area](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/c85afb09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/82e4c2e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Anchor In Distinctive Waterfront Lodging 0.6 km from Main Street Hyannis 9.4/10 Exceptional (1015) "Beautiful quaint hotel, with a nice view of the water. The place has a pool, a fire pit and nice spacious rooms. Would stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alberto CA $208 CA $310 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/76dbfadf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/10f6fac9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![VISIONARY KING ELITE](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/82541975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gift shop](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/ff5be5db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Uncommoner Hotel by Reverie Boutique Collection 1.9 km from Main Street Hyannis 9.2/10 Wonderful (80) "Great staff, beautiful property" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margaret CA $184 CA $210 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/West-Yarmouth-Hotels-Tidewater-Inn.h480770.Hotel-Information) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/dc2c7156.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/f6ec329c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/b2eb67f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/f33d73c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Cape Cod-West Yarmouth 1.7 km from Main Street Hyannis 8.8/10 Excellent (1001) "Excellent stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $145 CA $166 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/West-Yarmouth-Hotels-Hampton-Inn-Suites-Cape-Cod-West-Yarmouth.h2558618.Hotel-Information) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/85f07916.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, pub, pub](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/37259fda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/a80381e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/557f1a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bayside Resort Hotel 2.3 km from Main Street Hyannis 8.8/10 Excellent (1516) "Perfect location, clean rooms, lots of nice amenities, great parking Highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) NANCY CA $138 CA $175 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/West-Yarmouth-Hotels-Bayside-Resort-Hotel.h896697.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/9f940314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/ce103da5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two Double Beds](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/85ee8ddf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/cddd593a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Doubletree by Hilton Cape Cod - Hyannis 1 km from Main Street Hyannis 8.4/10 Very good (867) "Great location, awesome area for amenities, delicious cookies, as usual!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $155 CA $177 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/f7a87ca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/d4c5b048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/0231de53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/a26c3d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Hyannis - Cape Cod 0.3 km from Main Street Hyannis 8.0/10 Very good (1001) "Clean rooms; free parking on site" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reu Siega CA $137 CA $157 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/a974137b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/df083265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/dd4b8ad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/9db04da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Cod Hyannis 2.3 km from Main Street Hyannis 8.8/10 Excellent (626) "Nice hotel good breakfast options the mqll is in the back yard and lots of close by food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lawrence CA $141 CA $162 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Hyannis-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Cod-Hyannis.h7660.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/741b5772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/35291799.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/3225f1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/0271fbcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Harbor Hotel 0.6 km from Main Street Hyannis 8.0/10 Very good (1026) "This property was perfect for our fall weekend visit. We're looking forward to staying during the summer when the Bluewater Grill is open!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $171 CA $253 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/aa954682.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/d3887aa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/efa49ff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/6cc9c6b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cape Sands Inn 1.9 km from Main Street Hyannis 8.2/10 Very good (1004) "I love this hotel clean good up keep " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jerome CA $109 CA $124 total includes taxes & fees Nov 14 - Nov 15 [](https://www.expedia.ca/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/e4d68938.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/9d421872.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/0a9fa15c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Resort 0.3 km from Main Street Hyannis 7.6/10 Good (31) "Excellent location. Nicely equipped kitchenette." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $151 CA $173 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ![Room, 1 King Bed](https://images.trvl-media.com/lodging/10000000/9720000/9717400/9717349/93894fd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9720000/9717400/9717349/b7b0921f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/10000000/9720000/9717400/9717349/56fb3cfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/10000000/9720000/9717400/9717349/fd5c5eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Host Inn 1.6 km from Main Street Hyannis 7.8/10 Good (455) "Was a very nice stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $148 CA $170 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Host-Inn.h9717349.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/6128ed99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/5c644d21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/c18bcef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/99f74591.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Hyannis by IHG 2.9 km from Main Street Hyannis 8.2/10 Very good (961) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lilian CA $122 CA $139 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Hyannis-Hotels-Holiday-Inn-Hyannis-By-IHG.h12477.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/9afdfb4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/ef69e045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/786ccd3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Plaza Hotel 0.9 km from Main Street Hyannis 7.0/10 Good (939) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mirza CA $95 CA $123 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/900000/895300/895210/ef8e0c34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/900000/895300/895210/c720208e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/895300/895210/103e9cdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/900000/895300/895210/929a854e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area 1.5 km from Main Street Hyannis 7.0/10 Good (1008) "lots of things nearby easy to get to where you wanted to be " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) june CA $97 CA $110 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/West-Yarmouth-Hotels-Days-Inn-By-Wyndham-West-YarmouthHyannis-Cape-Cod-Area.h895210.Hotel-Information) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8200/8135/53ed8649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/8200/8135/1b122287.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/8200/8135/ed873d9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 King Bed, Golf View | View from room](https://images.trvl-media.com/lodging/1000000/10000/8200/8135/1d638eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cape Cod Irish Village 1.4 km from Main Street Hyannis 6.4/10 (1007) "We go on a September Cape cod golf trip every year and always stay at the Irish village. Great prices, food, and entertainment. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $160 CA $184 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Hyannis-Hotels-Resort-Conference-Center-At-Hyannis.h8135.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/540000/533000/532969/9bb322af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/533000/532969/ac9508eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/540000/533000/532969/6a90b735.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/540000/533000/532969/3b60e727.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge by Choice - Cape Cod 1.5 km from Main Street Hyannis 6.2/10 (493) "Rooms were dated but very clean. We would definitely stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $105 CA $120 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/West-Yarmouth-Hotels-Econo-Lodge.h532969.Hotel-Information) ![House](https://images.trvl-media.com/lodging/116000000/115550000/115540200/115540151/44ad2736.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/116000000/115550000/115540200/115540151/19663ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/116000000/115550000/115540200/115540151/92dddeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/116000000/115550000/115540200/115540151/w3000h2101x0y149-a7097f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Water Access 5-bed 2-bath Retreat 0.6 km from Main Street Hyannis CA $490 CA $1,292 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Hyannis-Hotels-Water-Access-5-Bed-2-Bath-Retreat.h115540151.Hotel-Information) ![Family House, Private Bathroom, Pool View | Shared kitchen](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/1de4e978.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Terrace/patio](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/4ede3fc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Shared kitchen](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/4a3b4c38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Restaurant](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/6936f2b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sal's Place 2.5 km from Main Street Hyannis CA $560 CA $808 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Hyannis-Hotels-Sals-Place.h119373964.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/00d26354.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/1c660188.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/2b1f0d40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/6a955bb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Village Inn Cape Cod 6.1 km from Main Street Hyannis 10/10 Exceptional (221) "It was so charming, would definitely stay there again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyle CA $236 CA $271 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Yarmouth-Port-Hotels-The-Village-Inn-Cape-Cod.h12426891.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-08&endDate=2025-11-09®ionId=6287458&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Main Street Hyannis Hotel Reviews ![Comfort Inn Hyannis - Cape Cod](//images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/f7a87ca8_y.jpg) ### Comfort Inn Hyannis - Cape Cod 10/10 Excellent "Their continental breakfast had more options than other hotels I’ve booked! Loved the breakfast choices! We enjoyed the food and our stay. Cozy and clean beds and our room ac worked perfectly! " [](https://expedia.ca/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Cape Sands Inn](//images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/aa954682_y.jpg) ### Cape Sands Inn 10/10 Excellent "Clean room nice view" [](https://expedia.ca/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) ![SeaCoast Inn](//images.trvl-media.com/lodging/10000000/9410000/9400300/9400206/90-92aafafd_y.jpg) ### SeaCoast Inn 10/10 Excellent "It was a 2 day stay as we traveled New England for our 25th Anniversary. The hotel was ideally situated for the town of Hyannis! 1 1/2 blocks from the waterfront harbor and 1/2 block from Main Street and the the shops, restaurants, museums, etc. that are based there! Great location! The hotel itself was older but still clean, well kept, and we had nothing bad to say about it, it was just older but was still attractive!" [](https://expedia.ca/Hyannis-Hotels-SeaCoast-Inn.h9400206.Hotel-Information) ![Hyannis Travel Inn](//images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/fe11d49f_y.jpg) ### Hyannis Travel Inn 10/10 Excellent "The hotel staff was great! Friendly and helpful. Really near the dock to catch the ferry to Nantucket. " [](https://expedia.ca/Hyannis-Hotels-Hyannis-Travel-Inn.h1379109.Hotel-Information) ![Fairfield Inn & Suites by Marriott Cape Cod Hyannis](//images.trvl-media.com/lodging/1000000/10000/7700/7660/a974137b_y.jpg) ### Fairfield Inn & Suites by Marriott Cape Cod Hyannis 10/10 Excellent "We stayed 6 nights. The hotel is very clean,quiet and has a great breakfast! It saves so much time to be able to have breakfast before we leave for the day. Coffee was always ready any time of day. And parking was so easy. They’ve got plenty of parking. It’s a place I’ll stay again for sure " [](https://expedia.ca/Hyannis-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Cod-Hyannis.h7660.Hotel-Information) ![Margaritaville Resort Cape Cod](//images.trvl-media.com/lodging/1000000/20000/12900/12897/b57e0b1f_y.jpg) ### Margaritaville Resort Cape Cod 10/10 Excellent "Resort was everything we wanted." [](https://expedia.ca/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Hyannis Plaza Hotel](//images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07_y.jpg) ### Hyannis Plaza Hotel 10/10 Excellent "Thank you, was good experience. Will stay again and will advise your hotel to my friend and family. " [](https://expedia.ca/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Ocean Street Inn on Hyannis Harbor](//images.trvl-media.com/lodging/5000000/4170000/4165800/4165795/cbe333f0_y.jpg) ### Ocean Street Inn on Hyannis Harbor 10/10 Excellent "When we arrived the hotel looked deserted so I called and found out they seem to have a few properties connected on the street. Mid October is off season so we were moved to the harbor hotel a block away. I was very grateful for this since the other one was a ghost town. Out stay at the harbor hotel was fabulous. Very large rooms, very clean, and all staff were great. This is also located across from the ferry so the location was perfect. We also enjoyed all of the restaurants on the street with Spanky’s being fabulous for their lobster roll. " [](https://expedia.ca/Hyannis-Hotels-Ocean-Street-Inn-On-Hyannis-Harbor.h4165795.Hotel-Information) ![Hampton Inn & Suites Cape Cod-West Yarmouth](//images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/dc2c7156_y.jpg) ### Hampton Inn & Suites Cape Cod-West Yarmouth 10/10 Excellent "Excellent stay." [](https://expedia.ca/West-Yarmouth-Hotels-Hampton-Inn-Suites-Cape-Cod-West-Yarmouth.h2558618.Hotel-Information) ## Hotels near other Main Street Hyannis attractions [](https://www.expedia.ca/John-F-Kennedy-Hyannis-Museum-Hotels.0-l6070185-0.Travel-Guide-Filter-Hotels) ![John F. Kennedy Hyannis Museum which includes a statue or sculpture](https://images.trvl-media.com/place/6070185/7e9e6a58-eb55-48ff-bc35-a3283de6db0c.jpg) ### John F. Kennedy Hyannis Museum 4.4/5 (259 reviews) Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6070185) [](https://www.expedia.ca/Cape-Cod-Maritime-Museum-Hotels.0-l553248635146342095-0.Travel-Guide-Filter-Hotels) ![Hyannis](https://images.trvl-media.com/place/553248635146342095/f4f9f2be-5681-4d82-8f2a-a01d46fc93fc.jpg) ### Cape Cod Maritime Museum You can spend an afternoon exploring the galleries in Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the seaside in this family-friendly area, or check out its seafood restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635146342095) [](https://www.expedia.ca/St-Francis-Xavier-Church-Hotels.0-l6286986-0.Travel-Guide-Filter-Hotels) ![Hyannis](https://images.trvl-media.com/place/6286986/68f1113f-193c-4991-a964-5912a97a8e48.jpg) ### St. Francis Xavier Church 4.4/5 (45 reviews) After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander the beautiful beaches and waterfront in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6286986) [](https://www.expedia.ca/John-F-Kennedy-Memorial-Hotels.0-l6286978-0.Travel-Guide-Filter-Hotels) ![John F. Kennedy Memorial which includes flowers](https://images.trvl-media.com/place/6286978/9b85082f-75c6-4ae3-ac16-7a3f1c71a2a9.jpg) ### John F. Kennedy Memorial 4.5/5 (110 reviews) Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6286978) [](https://www.expedia.ca/Hyannis-Armory-Hotels.0-l950930054190297088-0.Travel-Guide-Filter-Hotels) ### Hyannis Armory Learn about the local history of Hyannis when you take a trip to Hyannis Armory. Wander the waterfront and beautiful beaches in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=950930054190297088) [](https://www.expedia.ca/Hyannis-Youth-Community-Center-Hotels.0-l553248635976357139-0.Travel-Guide-Filter-Hotels) ### Hyannis Youth & Community Center You can take time to visit Hyannis Youth & Community Center during your travels to Hyannis. Stroll along the beautiful beaches or visit the shops in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635976357139) [](https://www.expedia.ca/Zion-Union-Heritage-Museum-Hotels.0-l724958852913086464-0.Travel-Guide-Filter-Hotels) ### Zion Union Heritage Museum You can spend an afternoon exploring the galleries in Zion Union Heritage Museum during your travels in Hyannis. Make time to visit the area's shops, or simply enjoy its seafood restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=724958852913086464) [](https://www.expedia.ca/Commotion-Charters-Hotels.0-l553248621532666521-0.Travel-Guide-Filter-Hotels) ### Commotion Charters Enjoy an outing to Commotion Charters during your stay in Hyannis. Attend a sporting event or simply enjoy the seafood restaurants while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532666521) ## Frequently asked questions ### What's the area like around Main Street Hyannis? > Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, check out the 179 hotels and other accommodations you'll find within a mile. ### What's the best hotel to stay near Main Street Hyannis? > Adjacent to Main Street Hyannis, [Hyannis Travel Inn](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Travel-Inn.h1379109.Hotel-Information) is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include [Hyannis Harbor Hotel](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) and [Comfort Inn Hyannis - Cape Cod](https://www.expedia.ca/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information). ### How many hotels can I expect to find close to Main Street Hyannis? > Expedia has 179 hotels and other accommodations within a mile from Main Street Hyannis. ### If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund? > Yes, you'll find most hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view top deals close to Main Street Hyannis. ### What can I see and do near Main Street Hyannis? > John F. Kennedy Hyannis Museum, Cape Cod Maritime Museum, and Whydah Pirate Museum feature captivating exhibits. Hyannis Harbor, Edward Gorey House, and Sandy Neck Lighthouse are landmarks that you won't want to miss. You can enjoy live performances at Cape Cod Melody Tent and Barnstable Performing Arts Center. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [4 Star Hotels in Hyannis](https://www.expedia.ca/4Star-Hyannis-Hotels.s40-0-d1544.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Hyannis](https://www.expedia.ca/5Star-Hyannis-Hotels.s50-0-d1544.Travel-Guide-Filter-Hotels) - [B&B in Barnstable County](https://www.expedia.ca/Barnstable-County-Bed-And-Breakfast.d553248635976434260-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Barnstable Hotels](https://www.expedia.ca/Barnstable-Hotels.d9658.Travel-Guide-Hotels) - [Hotels near Barnstable Municipal](https://www.expedia.ca/Barnstable-Municipal-Airport-Hotels.0-aHYA-0.Travel-Guide-Filter-Hotels) - [Bass River Hotels](https://www.expedia.ca/Bass-River-South-Yarmouth-Hotels.0-n553248635976383994-0.Travel-Guide-Filter-Hotels) - [Cape Cod Hotels](https://www.expedia.ca/Cape-Cod-Hotels.d180061.Travel-Guide-Hotels) - 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