Large rocks and a sandy beach with sparse vegetation.

Isla Santa María Vacation Rentals

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Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for Isla Santa María vacation rentals

An outdoor patio with a wooden table and benches, surrounded by plants and a wooden fence.

1. Torre Mar Galapagos Boutique Suites

Torre Mar Galapagos Boutique Suites
3.0 star property
Puerto Ayora
9.4 out of 10, Exceptional, (28 reviews)
"The host was so nice, kind, and friendly."
United States
Maho
The price is CA $186
CA $186 total
Oct 3 - Oct 4
Torre Mar Galapagos Boutique Suites
A patio with a round table and chairs, a blue umbrella, and a potted plant.

2. Suites

Suites
3.0 star property
Puerto Ayora
9.4 out of 10, Exceptional, (24 reviews)
"Check was early and friendly staff Room was super clean and comfortable"
United States
Judy
The price is CA $89
CA $101 total
Oct 3 - Oct 4
Suites
A building with a white exterior, wooden vertical elements, and a cactus plant in the foreground.

3. Villa Galapagos

Villa Galapagos
2.5 star property
Puerto Ayora
6.0 out of 10, (1 review)
"着いて早々にダブルブッキングがわかった。これは施設というよりも、貴社のシステムの問題。前回も宿泊名簿に名前がなかったこともあり、強く改善をもとめる。"
Japan
アオアシカツオドリ
The price is CA $115
CA $137 total
Oct 3 - Oct 4
Villa Galapagos
A couple sitting on a wicker sofa outdoors, with a table between them holding breakfast items and a book titled "GALAPAGOS".

4. Modern apartment with 18 feet ceilings and private terrace with view to a park

Modern apartment with 18 feet ceilings and private terrace with view to a park
Puerto Ayora
10.0 out of 10, Exceptional, (24 reviews)
"I highly recommend you stay here. Its is beautiful and also away from the crowd noise."
United States
Richard
The price is CA $160
CA $217 total
Oct 4 - Oct 5
Modern apartment with 18 feet ceilings and private terrace with view to a park
A bedroom with a bed, a chair, and a view of the sea through large windows.

5. Suite with spectacular ocean view, you will wake up to the sound of the sea.

Suite with spectacular ocean view, you will wake up to the sound of the sea.
Puerto Ayora
8.0 out of 10, Very good, (1 review)
The price is CA $128
CA $218 total
Oct 12 - Oct 13
Suite with spectacular ocean view, you will wake up to the sound of the sea.
A modern living room with a large table, a sofa, and a TV mounted on the wall.

6. Chic City Gateway: Spacious modern apartment in the Heart of Puerto Ayora

Chic City Gateway: Spacious modern apartment in the Heart of Puerto Ayora
Puerto Ayora
10.0 out of 10, Exceptional, (2 reviews)
"The place is perfect in every way, clean , spacious, great kitchen, comfortable beds, also the laundry facility is so helpful for longer stay. The host communication is excellent, immediate responds, great recommendations for the activities and local eats, location is also good , 10-15 minutes to walk to town center. we enjoyed our stay very much. highly recommend this place."
United States
Lihua
The price is CA $218
CA $309 total
Oct 3 - Oct 4
Chic City Gateway: Spacious modern apartment in the Heart of Puerto Ayora
A rooftop terrace with a wooden bench, a potted plant, and a view of the cityscape and mountains.

7. 2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora

2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora
Puerto Ayora
The price is CA $97
CA $125 total
Oct 3 - Oct 4
2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora
A modern living room with a sofa, ottoman, and coffee table, large windows, and a wooden ceiling beam.

8. Galapagos Coliving Ecuador Casa Tuna

Galapagos Coliving Ecuador Casa Tuna
3.0 star property
Puerto Ayora
2.0 out of 10, (1 review)
"Beware of this scam, the owner did not receive our reservstion nor the money!"
United States
Maya
The price is CA $212
CA $240 total
Oct 31 - Nov 1
Galapagos Coliving Ecuador Casa Tuna
A seal on a sandy beach with clear blue water and a rocky outcrop in the background.

9. Comfortable and cozy Galarous Island Suite

Comfortable and cozy Galarous Island Suite
Puerto Ayora
The price is CA $122
CA $150 total
Oct 3 - Oct 4
Comfortable and cozy Galarous Island Suite
A modern kitchen with a dining table, chairs, pendant lights, a refrigerator, and a large window with curtains.

10. Colmena Apartment in downtown Puerto Ayora, Santa Cruz

Colmena Apartment in downtown Puerto Ayora, Santa Cruz
Puerto Ayora
10.0 out of 10, Exceptional, (1 review)
"We had an excellent experience at Five minutes from the malecon Santa Cruz - Puerto Ayora. The property is brand new, very secure, and perfectly located. What truly made our stay special was our host, Gaby. She was always available, attentive, and ready to help us with anything we needed. Had we known about this place earlier, we would have booked it for our entire stay in Santa Cruz. We highly recommend this accommodation to anyone visiting the island — it’s a gem!"
United States
jacques
The price is CA $160
CA $245 total
Oct 3 - Oct 4
Colmena Apartment in downtown Puerto Ayora, Santa Cruz
An outdoor patio with a wooden table and benches, surrounded by plants and a wooden fence.

11. Island Life Two-Bedroom Galapagos Casita

Island Life Two-Bedroom Galapagos Casita
Puerto Ayora
10.0 out of 10, Exceptional, (4 reviews)
"The host John was absolutely the BEST. He went above and beyond to make our stay wonderful. The house had everything one would need. "
United States
Trevor K.
The price is CA $250
CA $282 total
Oct 4 - Oct 5
Island Life Two-Bedroom Galapagos Casita
A bedroom with a bed, a wooden wardrobe, a blue laundry basket, and a window with curtains.

12. TWO Bedrooms Apartment ON THE First Floor Forest View

TWO Bedrooms Apartment ON THE First Floor Forest View
Puerto Ayora
The price is CA $98
CA $141 total
Oct 3 - Oct 4
TWO Bedrooms Apartment ON THE First Floor Forest View
An aerial view of a marina with numerous boats docked, a pier with umbrellas, and a small building with a red roof.

13. Galapagos Family Vacation 3 BR. Centrally located and Ocean View

Galapagos Family Vacation 3 BR. Centrally located and Ocean View
Puerto Ayora
10.0 out of 10, Exceptional, (28 reviews)
"Great communication with host, gave us information ahead of time for laundry services and taxi. Clean and wonderful property close to everything and great views."
United States
Amanda
The price is CA $365
CA $664 total
Oct 3 - Oct 4
Galapagos Family Vacation 3 BR. Centrally located and Ocean View
A glass-top table with a chair on a balcony with blue walls and potted plants.

14. Galarous island apartments

Galarous island apartments
Puerto Ayora
The price is CA $128
CA $156 total
Oct 3 - Oct 4
Galarous island apartments
A multi-story building with a curved facade, balconies with glass railings, and a staircase leading to the upper floors.

15. TWO Bedrooms Apartment ON THE Ground Floor IN Ariana`s Galapagos Hostal

TWO Bedrooms Apartment ON THE Ground Floor IN Ariana`s Galapagos Hostal
Puerto Ayora
10.0 out of 10, Exceptional, (1 review)
"We enjoyed our 6-night stay at Ariana's. The apartment was large and comfortable. Bedroom air conditioners were whisper quiet. We especially enjoyed the rooftop terrace with its soft breezes. It’s a 20 minute walk to the big tortoise statue and a few minutes more to the Mlecon, or a 2 taxi ride."
Canada
Dean P.
The price is CA $98
CA $141 total
Oct 3 - Oct 4
TWO Bedrooms Apartment ON THE Ground Floor IN Ariana`s Galapagos Hostal
A microwave on a glass table with a coffee maker beside it.

16. A centrally located suite in Santa Cruz within easy reach of everything

A centrally located suite in Santa Cruz within easy reach of everything
Puerto Ayora
The price is CA $64
CA $107 total
Oct 3 - Oct 4
A centrally located suite in Santa Cruz within easy reach of everything
A hotel room with a blue-themed decor, including a dolphin artwork on the wall, a bed with a white and blue bedspread, and tropical leaf-patterned pillows.

17. Galarous serve you with quality and warmth in your home

Galarous serve you with quality and warmth in your home
Puerto Ayora
The price is CA $98
CA $127 total
Oct 3 - Oct 4
Galarous serve you with quality and warmth in your home
A kitchen with wooden cabinets, a refrigerator, and a dining table with chairs.

18. Torre Mar Galapagos Villa

Torre Mar Galapagos Villa
Puerto Ayora, Santa Cruz Island
10.0 out of 10, Exceptional, (1 review)
"We had a very nice time staying at Torre Mar. It was very conveniently located. We were 5 families...me (the mom) and my 4 kids, their spouses and 6 grandkids. Everyone had their own "suite". The advertising is a little confusing. I thought we were renting a "home", and then realized it was an apartment/hotel....but as I said, it was very nice for each family to have private space. The owner John was very friendly, although we did have some miscommunication issues, which is interesting...
United States
Betty A.
The price is CA $2,229
CA $2,544 total
Oct 6 - Oct 7
Torre Mar Galapagos Villa
A rooftop terrace with a wooden bench, a potted plant, and a view of the cityscape and mountains.

19. Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi

Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi
Puerto Ayora
The price is CA $117
CA $145 total
Oct 11 - Oct 12
Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi
A hotel room with a bed, a sofa, a dresser, a mirror, and a view of an outdoor patio with a table and chairs.

20. Spacious 6-bedroom building in superb Puerto Ayora with AC and no AC

Spacious 6-bedroom building in superb Puerto Ayora with AC and no AC
Puerto Ayora
10.0 out of 10, Exceptional, (1 review)
"Stay was great and I really enjoy Daniel’s helpful service— can’t wait to come back and stay again!"
United States
Will L.
The price is CA $142
CA $192 total
Oct 4 - Oct 5
Spacious 6-bedroom building in superb Puerto Ayora with AC and no AC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Isla Santa María Hotel Reviews

Hotel Cucuve

Hotel Cucuve

10/10 Excellent
"Excellent service!! A great hotel! We had a very pleasant experience. The staff were very friendly, very courteous and very helpful. I would definitely stay there again."
Taneisha 3-night trip
Posted 1 hour ago
Hotel Cucuve

Find out more about Isla Santa María

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Isla Santa María. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find vacation rentals in Isla Santa María?

Yes, we have vacation rentals in Isla Santa María near Galápagos National Park, or you can go with a more secluded option if you're looking for extra privacy while you relax.

What are some of the best vacation rentals that Isla Santa María has to offer?

Villa Galapagos: You might want to consider this vacation home rental near Isla Santa María, which is located near the beach and offers a private yard, air-conditioning, and daily housekeeping to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave.

What’s there to see and do in Isla Santa María?

Family-friendly attractions include Galápagos National Park, whereas Post Office Bay is a spot to enjoy the outdoors. Other places in town to visit include Punta Suarez.

What’s a vacation rental in Isla Santa María like?

Vacation rentals are private accommodations you can stay in for several days or longer in Isla Santa María. Vacation rentals provide amenities such as WiFi and washers and dryers so you'll have all the comforts of home. If you're concerned about cleanliness, a vacation rental can provide a sense of safety away from public hotel elevators and busy reception areas while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for a family trip.