Guadalupe County Vacation Packages

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    Save up to CA $4,200 when you book a flight and hotel together*

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Your Guadalupe County Vacation

Our Guadalupe County vacation packages provide an easy, affordable and immersive way to enjoy all that this unique destination has to offer. If it's nature and culture you're looking for, this is the place to be. Be sure to include Santa Rosa and Vaughn on your list of cities to explore when planning your trip to Guadalupe County. Expedia has flights, hotels and everything else you need to help you organize your own customized Guadalupe County vacation today.

Top vacation destinations in Guadalupe County

A grassy field with a stormy sky.
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Vaughn

Vaughn

Guadalupe County Hotel Deals

Hotel Blue 66, BW Signature Collection

Hotel Blue 66, BW Signature Collection

2.5 out of 5
2533 Historic Route 66 Santa Rosa NM
Fully refundableReserve now, pay when you stay
The price is CA $159 per night from Jul 4 to Jul 5
CA $159
CA $180 total
Jul 4 - Jul 5
includes taxes & fees
8.4/10 Very good! (343 reviews)
"The property is under new ownership and they have renovated the rooms and exterior beautifully while still maintaining the 60s Route 66 ambiance perfectly! It’s a lovely blast from the past! Breakfast was nice also !"

Reviewed on Jul 3, 2026

Hotel Blue 66, BW Signature Collection
La Quinta Inn & Suites by Wyndham Santa Rosa

La Quinta Inn & Suites by Wyndham Santa Rosa

3 out of 5
2277 Historic Route 66 Santa Rosa NM
Fully refundableReserve now, pay when you stay
The price is CA $197 per night from Jul 12 to Jul 13
CA $197
CA $223 total
Jul 12 - Jul 13
includes taxes & fees
9.2/10 Wonderful! (1,517 reviews)
"Hotel was great, clean rooms and kind staff"

Reviewed on Jul 2, 2026

La Quinta Inn & Suites by Wyndham Santa Rosa
Comfort Inn Santa Rosa on Route 66

Comfort Inn Santa Rosa on Route 66

2.5 out of 5
2524 Historic Route 66 Santa Rosa NM
Fully refundable
The price is CA $144 per night from Aug 2 to Aug 3
CA $144
CA $163 total
Aug 2 - Aug 3
includes taxes & fees
8.4/10 Very good! (1,004 reviews)
"Very easy, clean good parking felt safe reasonably priced"

Reviewed on Jul 3, 2026

Comfort Inn Santa Rosa on Route 66
See all 26 properties in Guadalupe County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Beach Vacations
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Family Vacations

Frequently asked questions

How much does a Guadalupe County vacation package cost?
We make it easy for everyone to travel, with Guadalupe County packages starting from as low as . You'll have the flexibility to combine your favorite airlines, hotels and car rental. For the ultimate escape, why not add a couple of experiences and tours to your travel itinerary?
How do I get a cheap travel package to Guadalupe County?
Track down flights that fit in with your schedule, add a hotel to your booking and watch the savings grow with a Guadalupe County vacation package. It's as easy as that! From flights and hotels to activities and rental cars, Expedia is where your cheap vacation begins. And with over 550 partner airlines and 1,000,000 hotel options all over the world to choose from, you won't be short of choice.
What are the top hotels in Guadalupe County?
If you're headed to Santa Rosa, you can't beat La Quinta Inn & Suites by Wyndham Santa Rosa and Super 8 by Wyndham Santa Rosa. Both are excellent bases for discovering this unique Guadalupe County city.
How far in advance should I book my Guadalupe County vacation?
Reserving your flights early with Expedia means one less thing to have to worry about. Most carriers display prices up to 12 months in advance. This is typically the cheapest time to book. If circumstances have left you booking late, discount tickets to Guadalupe County sometimes become available in the weeks leading up to departure.
What does an Expedia Guadalupe County travel package include?
From hotels and airfares to car rentals, Expedia can help you shape a Guadalupe County package that's ideal for you. Vacationing for a week or longer? Check out a hotel, rental car and flight bundle. If you're taking a quick break, an airfare and hotel deal could suit you better. Experiences can also be added after you've booked. Our packages make it a breeze to save and plan.
What should I know before booking a Guadalupe County travel package?
So many places to wander around, so many things to do. With a package, you can cross more of them off your list. Bundle your flights, rental cars and hotels and score big savings.
Can I choose my airline with a Guadalupe County Expedia vacation package?
Yes, you're in charge. We have access to over 550 partner airlines across the globe, so you can tailor your Guadalupe County adventure according to your travel needs.
If I'm not able to travel, can I cancel my Guadalupe County vacation package?
We understand — life sometimes gets in the way of your plans. If you've locked in a Guadalupe County vacation package and need to change or cancel it, we're here to help. We suggest taking a look at our Customer Service Portal first for information. But generally, if you've taken out your package in the last 24 hours, you may be able to cancel or amend your itinerary at no cost. If it's been more than 24 hours, your airline, hotel or car rental company may impose a charge.

Stay near popular Guadalupe County attractions

An old, weathered building with a stone roof and a small window, surrounded by a cemetery with headstones and a metal fence.

St. Rose of Lima Catholic Church

7.8/10 (48 reviews)
After visiting St. Rose of Lima Catholic Church, make a plan to see the other sights and activities in Santa Rosa. While in this quaint area, you can savor the top-notch restaurants.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.