Title: Hotels Near Florence Airport - Florence Regional Airport (FLO) | Expedia.ca [Florence Travel Guide](https://expedia.ca/Florence.dx1221)[Vacation Rentals in Florence](https://expedia.ca/Florence-Vacation-Rentals.d1221.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.ca/Cheap-Flights-To-Florence.d1221.Travel-Guide-Flights)[Florence Regional Car Rentals](https://expedia.ca/Car-Rentals-In-Florence-Regional.d6027805.Car-Rental-Guide)[Florence Vacation Packages](https://expedia.ca/Florence.d1221.Destination-Travel-Guides) ![Florence_McleodRegionalMedicalCenter_6162127_0006](https://images.trvl-media.com/place/6162127/fc91dc39-457a-4bce-865f-7d732cbd43f6.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Florence Hotels near Florence Regional Airport (FLO) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 23 - Dec 24](https://www.expedia.ca/Hotel-Search?regionId=6027805&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 24 - Dec 25](https://www.expedia.ca/Hotel-Search?regionId=6027805&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6027805&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6027805&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Top Florence Regional Hotel Reviews ![Best Western Inn](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf_y.jpg) ### Best Western Inn 10/10 Excellent "Clean room, good breakfast and front desk staff " [](https://expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg) ### Park Inn by Radisson Florence, SC 10/10 Excellent "Every thing perfect as always" [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Hyatt Place Florence Downtown](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321_y.jpg) ### Hyatt Place Florence Downtown 10/10 Excellent "Great experience in a nice hotel in downtown." [](https://expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Clean, safe room" [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695_y.jpg) ### La Quinta Inn & Suites by Wyndham Florence 10/10 Excellent "Clean room & breakfast was good. Checkin staff was great, friendly and professional. " [](https://expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ![Hotel Florence, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/7000000/6130000/6129000/6128999/af0558b8_y.jpg) ### Hotel Florence, Tapestry Collection by Hilton 10/10 Excellent "Room spotless. Staff courteous. 👍" [](https://expedia.ca/Florence-Hotels-Hotel-Florence.h6128999.Hotel-Information) ![Pineapple House: Historic. Southern Charm. Walk Downtown.](https://images.trvl-media.com/lodging/74000000/73070000/73061000/73060957/54a0fac3_y.jpg) ### Pineapple House: Historic. Southern Charm. Walk Downtown. 10/10 Excellent "This was a beautifully restored 1935 home. We had a wonderful time. The rental is the bottom floor of this house. There was no significant notice of upstairs renters who were there at the time. The home is very clean with no bugs. King bed is very comfortable. This is in an older section of town but very quiet and well kept. This appeared to be a safe area of town.This downstairs rental seem to have sole access to the front porch and the entire backyard with fire pit. We did not enjoy, but it was inviting.Easy access to everything. We had no issues and did not require assistance, but had good communication prior to arrival. We were very pleased with this home and will be staying again when we come back to visit family." [](https://expedia.ca/Florence-Hotels-Pineapple-House-Historic-Southern-Charm-Walk-Downtown.h73060957.Hotel-Information) ![Walking distance from one of South Carolina's top Medical centers.](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc_y.jpg) ### Walking distance from one of South Carolina's top Medical centers. 10/10 Excellent "Everything was great!" [](https://expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![3-bedroom mobile home in Florence, SC](https://images.trvl-media.com/lodging/118000000/117070000/117063100/117063033/ec031022_y.jpg) ### 3-bedroom mobile home in Florence, SC 10/10 Excellent "We were there for a friends wedding. We had a great time. Friday night family game (board game) night. Great place to stay to spend family time together. " [](https://expedia.ca/Florence-Hotels-3-Bedroom-Mobile-Home-In-Florence.h117063033.Hotel-Information) ## Frequently asked questions ### What's the area like near Florence, SC (FLO-Florence Regional)? ### What's the best place to stay close to Florence, SC (FLO-Florence Regional)? ### How many hotels will I find close to Florence, SC (FLO-Florence Regional)? ---