Top Guest Houses in Durham County in 2026

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Our top choices for Durham County guest houses

A modern two-story house with a wooden deck, a dark grey exterior, and a white upper section.

1. Tiny Home in the Bull City-Walk to Duke Hospital

Durham

karen e.

CA $411 total

includes taxes & fees

Nov 29 - Nov 30

A two-story building with a balcony, a patio with seating, and a gravel pathway.

2. Downtown Centric, Tucked Away, Fenced, PetsOK

Durham

CA $358 total

includes taxes & fees

Nov 16 - Nov 17

A modern building with a wooden deck and a metal fence.

3. Dog Friendly New Tiny Home Near Duke

Durham

"When we first saw this rental, I was hesitant not because it was a tiny house, but how immaculate it was from the pictures from the outside to the inside, Pictures sometime unfortunately tell a different story from reality. Not in this case!When we arrived, I went in and checked out the rental and was blown away at the cleanliness, the supplies to use, and the overall condition. This place was immaculate! everything looked as if the place was brand new and we were the first renters, that just...

jeffery w.

CA $363 total

includes taxes & fees

Nov 16 - Nov 17

A wooden deck leading to a modern house with large windows and a black metal gate.

4. Stylish and Modern Guesthouse in Downtown Durham

Durham

CA $440 total

includes taxes & fees

Nov 16 - Nov 17

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Top Durham County Hotel Reviews

The Lodge at Duke Medical Center

8/10 Good

"Clean, helpful staff, conveniently located. It is a great option. However, the walls are very thin, so you can hear conversations, TVs, and alarm clocks from other rooms. If noise bothers you, it is not the place for you."