10 Best Spa Resorts in Mississippi for 2026 | Expedia

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A large hotel with a prominent billboard advertising a car giveaway.

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Nov 14 - Nov 15

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Nov 15 - Nov 16

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Nov 20 - Nov 22

In two weeks

Nov 27 - Nov 29

Map of Mississippi

Our top choices for Mississippi hotels with a spa

A reception desk with a dark, textured surface and decorative leaf patterns. It features multiple shelves with various items and a central vase with flowers.

1. The Westin Jackson

Downtown Jackson

Immerse in a luxurious wellness retreat with 7 serene treatment rooms at Soul Spa, complemented by an indoor pool and exceptional dining.

CA $259 total

includes taxes & fees

Nov 22 - Nov 23

A well-furnished living room with a sofa, armchairs, a coffee table, and a large abstract painting on the wall.

2. Beau Rivage

Downtown Biloxi

Revitalize at this waterfront resort with 14 treatment rooms and couples massage suites where deep soaking tubs complement spa journeys.

CA $209 total

includes taxes & fees

Nov 30 - Dec 1

A modern hotel lobby with a reception desk, seating area, and unique lighting fixtures.

3. Tru By Hilton Tupelo

Tupelo

CA $152 total

includes taxes & fees

Dec 6 - Dec 7

A hotel with a prominent entrance, a parking lot, and a clear sky.

4. Hilton Garden Inn Memphis/Southaven, MS

Southaven

CA $254 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a fireplace, seating area, and a large window.

5. Hampton Inn Jackson/Flowood (Airport Area) MS

Flowood

CA $149 total

includes taxes & fees

Nov 21 - Nov 22

A hotel with a swimming pool, outdoor seating, and palm trees.

6. Silver Slipper Casino & Hotel - Adults Only

Bay St Louis

CA $123 total

includes taxes & fees

Nov 17 - Nov 18

An outdoor patio with seating, a fire pit, and string lights.

7. Home2 Suites by Hilton Jackson/Pearl, MS

Pearl

CA $163 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a dark blue wall, a stone fireplace, two patterned chairs, a black sofa, and a wooden floor.

8. Hotel DeSoto

Olive Branch

CA $153 total

includes taxes & fees

Dec 6 - Dec 7

A modern hotel with a covered entrance, multiple floors, and a well-lit facade.

9. La Quinta Inn & Suites by Wyndham Oxford

Oxford

CA $139 total

includes taxes & fees

Dec 4 - Dec 5

A reception area with a wooden partition, two grey upholstered chairs, a desk with a lamp, and a mirror above the counter.

10. Holiday Inn Express and Suites Winona North by IHG

Winona

CA $166 total

includes taxes & fees

Dec 12 - Dec 13

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Top Mississippi Hotel Reviews

A well-furnished living room with a sofa, armchairs, a coffee table, and a large abstract painting on the wall.

Beau Rivage

Downtown Biloxi

10/10 Excellent

Canada

Carlo

A reception area with a white desk, two armchairs, a round coffee table, and a large painting on the wall.

The Peabody Memphis

Downtown Memphis

10/10 Excellent

Canada

laura

A living room with a chandelier, two sofas, a coffee table, and a fireplace.

The Inn at Cedar Grove

Vicksburg

10/10 Excellent

For first time visitors to Vicksburg who came with an interest in the city's history, there couldn't have been a better place to stay than the Inn at Cedar Grove. The mansion is an amazing specimen of Civil War era design and furnishing, and the post-breakfast tour of the home really put us in a state of mind to appreciate all that we saw at the many museums in the town, and on our visit to the Vicksburg Military Park. The no-menu included breakfast was a bit rough - if you have dietary issues...

Canada

STEVE

A spa area with a stone wall, a waterfall feature, and a tiled floor.

IP Casino Resort Spa - Biloxi

Biloxi

10/10 Excellent

Canada

Wayne

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