10 Best Spa Resorts in Mississippi for 2026 | Expedia

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Top Cities in Mississippi

A beach with wooden chairs and colorful umbrellas, a pier extending into the water, and a lifeguard tower in the background.

Check availability on Mississippi Spa Hotels

Tonight

Oct 10 - Oct 11

Tomorrow

Oct 11 - Oct 12

Next weekend

Oct 16 - Oct 18

In two weeks

Oct 23 - Oct 25

Our top choices for Mississippi hotels with a spa

A reception desk with a dark, textured surface and decorative leaf patterns. It features multiple shelves with various items and a central vase with flowers.

1. The Westin Jackson

Downtown Jackson

Immerse in a luxurious wellness retreat with 7 serene treatment rooms at Soul Spa, complemented by an indoor pool and exceptional dining.

CA $246 total

includes taxes & fees

Oct 18 - Oct 19

A well-furnished living room with a sofa, armchairs, a coffee table, and a large abstract painting on the wall.

2. Beau Rivage

Downtown Biloxi

Revitalize at this waterfront resort with 14 treatment rooms and couples massage suites where deep soaking tubs complement spa journeys.

CA $240 total

includes taxes & fees

Oct 11 - Oct 12

A modern hotel lobby with a reception desk, seating area, and unique lighting fixtures.

3. Tru By Hilton Tupelo

Tupelo

CA $152 total

includes taxes & fees

Oct 25 - Oct 26

A gym with treadmills, elliptical machines, and weightlifting equipment.

4. Hilton Garden Inn Memphis/Southaven, MS

Southaven

CA $265 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a reception desk, seating area, and large windows.

5. Hampton Inn Jackson/Flowood (Airport Area) MS

Flowood

CA $168 total

includes taxes & fees

Nov 8 - Nov 9

A hotel pool with sunbathing chairs, a water feature, and a view of the sunset.

6. Silver Slipper Casino & Hotel - Adults Only

Bay St Louis

CA $122 total

includes taxes & fees

Oct 21 - Oct 22

An outdoor patio with seating, a fire pit, and string lights.

7. Home2 Suites by Hilton Jackson/Pearl, MS

Pearl

CA $162 total

includes taxes & fees

Nov 1 - Nov 2

A hotel named 'HOTEL DESOTO' with a modern facade, numbered address 8877, and a symmetrical window design.

8. Hotel DeSoto

Olive Branch

CA $115 total

includes taxes & fees

Oct 11 - Oct 12

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Top Mississippi Hotel Reviews

Margaritaville Resort Biloxi

Margaritaville Resort Biloxi

10/10 Excellent

"Everything was great"

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