10 Best Spa Resorts in Mississippi for 2026 | Expedia

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Top Cities in Mississippi

A beach with wooden chairs and colorful umbrellas, a pier extending into the water, and a lifeguard tower in the background.

Check availability on Mississippi Spa Hotels

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Our top choices for Mississippi hotels with a spa

A reception desk with a dark, textured surface and decorative leaf patterns. It features multiple shelves with various items and a central vase with flowers.

1. The Westin Jackson

Downtown Jackson

Immerse in a luxurious wellness retreat with 7 serene treatment rooms at Soul Spa, complemented by an indoor pool and exceptional dining.

CA $228 total

includes taxes & fees

Nov 8 - Nov 9

A well-furnished living room with a sofa, armchairs, a coffee table, and a large abstract painting on the wall.

2. Beau Rivage

Downtown Biloxi

Revitalize at this waterfront resort with 14 treatment rooms and couples massage suites where deep soaking tubs complement spa journeys.

CA $235 total

includes taxes & fees

Oct 29 - Oct 30

A modern hotel lobby with a reception desk, seating area, and unique lighting fixtures.

3. Tru By Hilton Tupelo

Tupelo

CA $149 total

includes taxes & fees

Nov 22 - Nov 23

An indoor swimming pool with clear water, marked depth lines, and a tiled floor.

4. Hilton Garden Inn Memphis/Southaven, MS

Southaven

CA $221 total

includes taxes & fees

Nov 23 - Nov 24

A spacious lobby with a reception desk, seating area, and large windows.

5. Hampton Inn Jackson/Flowood (Airport Area) MS

Flowood

CA $149 total

includes taxes & fees

Nov 20 - Nov 21

A hotel pool with sunbathing chairs, a water feature, and a view of the sunset.

6. Silver Slipper Casino & Hotel - Adults Only

Bay St Louis

CA $121 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor patio with seating, a fire pit, and string lights.

7. Home2 Suites by Hilton Jackson/Pearl, MS

Pearl

CA $159 total

includes taxes & fees

Nov 1 - Nov 2

A hotel named 'HOTEL DESOTO' with a modern facade, numbered address 8877, and a symmetrical window design.

8. Hotel DeSoto

Olive Branch

CA $150 total

includes taxes & fees

Nov 1 - Nov 2

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Top Mississippi Hotel Reviews

IP Casino Resort Spa - Biloxi

IP Casino Resort Spa - Biloxi

10/10 Excellent

"⭐️⭐️⭐️⭐️⭐️"

Baymont by Wyndham Jackson/Ridgeland

Baymont by Wyndham Jackson/Ridgeland

10/10 Excellent

"Very nice presentation when we came in, everything looks clean and spacious. Helpful staff got us to our room which was also nice and clean. We had the most comfortable bed of any hotel I ever slept in, and it was an excellent free breakfast with multiple hot options. Would definitely book again."

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