Commerce Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Vacation Rentals in Commerce

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (136)
"The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area."
The price is CA $204
CA $332 total
includes taxes & fees
Jul 25 - Jul 26
Serenity South -- Gardens, River-Views, and Refreshing Space

Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.

8.6 out of 10, Excellent, (16)
"Very clean and spacious. Great location with River Walk and several good restaurants within walking distance. Check in was smooth and host was very responsive. "
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

9.8 out of 10, Exceptional, (35)
"Nice place to stay! Clean, able to walk to everything!"
The price is CA $111
CA $188 total
includes taxes & fees
Jul 30 - Jul 31
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Peaceful secluded cabin located near Horseshoe Lake

9.8 out of 10, Exceptional, (14)
"This stay was comfortable and quiet an amazing weekend stay!!"
The price is CA $190
CA $280 total
includes taxes & fees
Jul 28 - Jul 29
Peaceful secluded cabin located near Horseshoe Lake

Special Offer for Weekly & Monthly Stays in August & September at "Brickyard"

10.0 out of 10, Exceptional, (20)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
Special Offer for Weekly & Monthly Stays in August & September at "Brickyard"

Loft Apartment Across From Semo University Houch Field House. Walk To Events

10.0 out of 10, Exceptional, (88)
"Very nice place! I needed a place to stay for the month for clinical rotations for school, and the property owner worked with me with pricing. The loft is in the middle of everything in Cape! Highly recommend."
The price is CA $204
CA $250 total
includes taxes & fees
Jul 30 - Jul 31
Loft Apartment Across From Semo University Houch Field House. Walk To Events

Cozy cabins on beautiful Horseshoe Lake

9.8 out of 10, Exceptional, (32)
"Its a nice place to stay! "
The price is CA $141
CA $168 total
includes taxes & fees
Jul 30 - Jul 31
Cozy cabins on beautiful Horseshoe Lake

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
9.8 out of 10, Exceptional, (18)
"It was exactly what we were looking for and exceeded our expectations. We plan to be back! The hosts were wonderful! "
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

The Rested Duck Mallard Room

9.2 out of 10, Wonderful, (22)
"Great location and we are looking forward to a return trip. "
The price is CA $141
CA $178 total
includes taxes & fees
Jul 30 - Jul 31
The Rested Duck Mallard Room

Little Blue Cottage on Spanish

8.6 out of 10, Excellent, (42)
"Has everything you need. Comfy and in a great location. "
The price is CA $110
CA $137 total
includes taxes & fees
Jul 30 - Jul 31
Little Blue Cottage on Spanish

The Twisted Sassafras Treehouse

10.0 out of 10, Exceptional, (16)
"My wife and I thoroughly enjoyed our stay here! A beautiful place built on a beautiful property; we enjoyed the hot tub under the stars and the morning coffee on the porch (and another hot tub ). Great place for some R&R, and excellent communication with the owner in advance. Wouldn’t hesitate to book again."
The price is CA $280
CA $410 total
includes taxes & fees
Aug 4 - Aug 5
The Twisted Sassafras Treehouse

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (36)
"Great stay, great location! "
Quaint, Beautiful Home next to SEMO and Hospital

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (217)
"This is our second time staying at the Kage House. Didnt disappoint at all. Great location! "
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (4)
"The home was beautiful inside and very clean. The bed was comfortable, and the area was quiet. My father and I really enjoyed our stay. I would stay there again over anywhere else I have stayed in cape. "
River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi

River Town Retreat near SEMO

9.0 out of 10, Wonderful, (2)
"Very nice place only downsize albeit cute is the claw foot tub with make shift shower, The unit worked very well for what we were looking for near SEMO campus"
River Town Retreat near SEMO

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (32)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is CA $244
CA $368 total
includes taxes & fees
Jul 27 - Jul 28
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Charming Secluded Getaway Cabin within minutes of amenities

10.0 out of 10, Exceptional, (14)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
Charming Secluded Getaway Cabin within minutes of amenities

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (7)
"Lovely home with historic architectural features in tact. Fully stocked, great location, quite neighborhood. We thoroughly enjoyed our stay."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Gorgeous 1856 Log Cabin, Completely Renovated

10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
The price is CA $272
CA $423 total
includes taxes & fees
Jul 30 - Jul 31
Gorgeous 1856 Log Cabin, Completely Renovated

The Blue Door

10.0 out of 10, Exceptional, (1)
The price is CA $143
CA $170 total
includes taxes & fees
Aug 13 - Aug 14
The Blue Door
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Commerce Hotel Reviews

Frequently asked questions

Are there vacation rentals in Commerce?

Yes, you can find vacation rentals near top attractions in Commerce, or you can go with a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Commerce?

Serenity South -- Gardens, River-Views, and Refreshing Space: This vacation home rental outside of Commerce is located on a river and has a fireplace, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games.

What’s there to see and do in Commerce?

Explore the area and family-friendly sights such as Cape Splash Family Aquatic Center, or get out into nature at a spot like Mississippi River. In the larger area, you’ll find Isle Casino Cape Girardeau and Southeast Missouri State University.

What’s a vacation rental in Commerce like?

Vacation rentals are private properties you can stay in for several days or longer in Commerce. Vacation rentals feature extras like WiFi and washers and dryers so you'll feel just like you're at home. If you're concerned about a sanitized environment, vacation rentals can offer a sense of safety away from public hotel elevators and busy front desks while still allowing you to travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for family gatherings.