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Recommended hotels in Cairo

1. Quality Inn Cairo I-57
Quality Inn Cairo I-57Cairo
6.4 out of 10, (296 reviews)
The price is CA $97
CA $107 total
includes taxes & fees
Nov 15 - Nov 16

2. Eagle Inn Charleston
Eagle Inn CharlestonCharleston
6.6 out of 10, (107 reviews)
The price is CA $92
CA $103 total
includes taxes & fees
Nov 8 - Nov 9

3. Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MOCharleston
6.8 out of 10, (684 reviews)
The price is CA $82
CA $92 total
includes taxes & fees
Dec 1 - Dec 2

4. La Center Motel
La Center MotelLa Center
7.8 out of 10, Good, (24 reviews)
The price is CA $71
CA $83 total
includes taxes & fees
Dec 4 - Dec 5

5. The Riverstone Hotel Charleston-Sikeston
The Riverstone Hotel Charleston-SikestonCharleston
6.8 out of 10, (443 reviews)
The price is CA $93
CA $104 total
includes taxes & fees
Nov 8 - Nov 9

6. Peaceful secluded cabin located near Horseshoe Lake
Peaceful secluded cabin located near Horseshoe LakeMiller City
9.8 out of 10, Exceptional, (39 reviews)
The price is CA $196
CA $286 total
includes taxes & fees
Dec 6 - Dec 7

7. Cozy cabins on beautiful Horseshoe Lake
Cozy cabins on beautiful Horseshoe LakeOlive Branch
9.8 out of 10, Exceptional, (44 reviews)
The price is CA $158
CA $173 total
includes taxes & fees
Nov 7 - Nov 8

8. The Rested Duck Mallard Room
The Rested Duck Mallard RoomOlive Branch
9.4 out of 10, Exceptional, (32 reviews)
The price is CA $158
CA $173 total
includes taxes & fees
Nov 7 - Nov 8

9. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Peaceful 2-bedroom cabin with AC in welcoming Villa RidgeVilla Ridge
10.0 out of 10, Exceptional, (6 reviews)
The price is CA $252
CA $354 total
includes taxes & fees
Dec 5 - Dec 6

10. Quiet Country Stay: Modern Home Near Paducah
Quiet Country Stay: Modern Home Near PaducahCunningham
The price is CA $208
CA $406 total
includes taxes & fees
Dec 5 - Dec 6

11. Quiet Country Stay: Modern Home Near Paducah
Quiet Country Stay: Modern Home Near PaducahCunningham
10.0 out of 10, Exceptional, (4 reviews)
The price is CA $152
CA $396 total
includes taxes & fees
Nov 9 - Nov 10

12. Charming Home just minutes from Interstate and Mall
Charming Home just minutes from Interstate and MallKevil
10.0 out of 10, Exceptional, (26 reviews)
The price is CA $154
CA $277 total
includes taxes & fees
Nov 22 - Nov 23

13. Charming cottage overlooking Lake Acre
Charming cottage overlooking Lake AcreDongola
10.0 out of 10, Exceptional, (107 reviews)
The price is CA $210
CA $363 total
includes taxes & fees
Dec 1 - Dec 2

14. Perfect Couples Retreat - firepit
Perfect Couples Retreat - firepitCarlisle County
10.0 out of 10, Exceptional, (1 review)
The price is CA $171
CA $250 total
includes taxes & fees
Nov 9 - Nov 10

15. The Roost | Hot Tub, Ponds & Farm Views
The Roost | Hot Tub, Ponds & Farm ViewsCarlisle County
The price is CA $200
CA $283 total
includes taxes & fees
Nov 12 - Nov 13
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Cairo
At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.














































