Title: 5 Stars Hotels in Texas Medical Center, Houston from CA $104 - Find Cheap Texas Medical Center Hotels With 5 Stars | Expedia.ca [Texas Medical Center Travel Guide](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Texas Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Texas-Medical-Center.d6143504.Car-Rental-Guide)[Texas Medical Center Vacations](https://expedia.ca/Texas-Medical-Center.d6143504.Destination-Travel-Guides) ![Houston_TexasChildrensHospital_553248635389801905_9](https://images.trvl-media.com/place/553248635389801905/db4dee74-4310-41e3-8220-625d7fc800e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635389801905/db4dee74-4310-41e3-8220-625d7fc800e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Texas Medical Center 5 Star Hotels Tonight [Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2026-01-29&endDate=2026-01-30&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 30 - Jan 31](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2026-01-30&endDate=2026-01-31&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2026-01-30&endDate=2026-02-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Texas Medical Center 5-star hotels ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/4f62da1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/5df7d594.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/6d993ec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/eb25cb32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Post Oak Hotel at Uptown Houston [](https://www.expedia.ca/Houston-Hotels-The-Post-Oak-Hotel-At-Uptown-Houston.h22340244.Hotel-Information) The Galleria 9.6/10 Exceptional (907 reviews) "The staff is excellent and the hotel is beautiful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stacy CA $688 CA $806 total includes taxes & fees Feb 12 - Feb 13 [](https://www.expedia.ca/Houston-Hotels-The-Post-Oak-Hotel-At-Uptown-Houston.h22340244.Hotel-Information) ![Lunch and dinner served, Chinese cuisine](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/cc0b23d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/a3c1fcc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite, 1 King Bed, Jetted Tub](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/c7aca6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/939d8a85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ACP Hotel Houston Westchase, MOD Collection by Sonesta [](https://www.expedia.ca/Houston-Hotels-ACP-Hotel-Westchase.h1155962.Hotel-Information) Sharpstown 8.0/10 Very good (1,001 reviews) "room clean and staffs very nice and the hotel close to restaurants and shopping . I will stay there when I visit Houston Texas ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) johnny CA $89 CA $104 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/Houston-Hotels-ACP-Hotel-Westchase.h1155962.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/b96bd2d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/28562123.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/bf3873ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/ebf75271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel Houston [](https://www.expedia.ca/Houston-Hotels-Four-Seasons-Hotel-Houston.h20193.Hotel-Information) Downtown Houston 9.2/10 Wonderful (1,003 reviews) "The hotel and staff were impeccable, as usual. We enjoyed exquisite food and drinks in both restaurants. The complimentary transportation for MD Anderson was great as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diana CA $785 CA $926 total includes taxes & fees Feb 14 - Feb 15 [](https://www.expedia.ca/Houston-Hotels-Four-Seasons-Hotel-Houston.h20193.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/cb931bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine ](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/08f93781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/75cdec53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/abba9635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### JW Marriott Houston Downtown [](https://www.expedia.ca/Houston-Hotels-JW-Marriott-Houston-Downtown.h7301257.Hotel-Information) Downtown Houston 9.0/10 Wonderful (1,004 reviews) "Friendly staff, good food and drink options on site, nice spacious room" ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Vaughan CA $313 CA $376 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Houston-Hotels-JW-Marriott-Houston-Downtown.h7301257.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/a5513bed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/66490e59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/e63fc77a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/9de7a228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Houston Grand Hotel - River Oaks [](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information) The Galleria 9.2/10 Wonderful (405 reviews) "Clean room and good service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JAIME A CHAPA CA $284 CA $336 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/faff2120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/2fc8cb04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves breakfast, lunch, and dinner](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/805d0af4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/6fdda361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Colombe d'Or Hotel [](https://www.expedia.ca/Houston-Hotels-La-Colombe-DOr-Hotel-Restaurant.h66954154.Hotel-Information) Montrose 9.4/10 Exceptional (154 reviews) "Everything was absolutely amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice CA $527 CA $617 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/Houston-Hotels-La-Colombe-DOr-Hotel-Restaurant.h66954154.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/587b4f3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment, 2 Bedrooms | Private kitchen](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/e7517105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Living area](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/ed4d8344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment, 2 Bedrooms | Terrace/patio](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/4a5f58a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 7550 Kirby Dr [](https://www.expedia.ca/Houston-Hotels-7550-Kirby-Dr.h96248257.Hotel-Information) Braeswood Place 8.2/10 Very good (43 reviews) "I enjoyed my stay it was worth it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yontee [](https://www.expedia.ca/Houston-Hotels-7550-Kirby-Dr.h96248257.Hotel-Information) ![Luxury Villa | Living area](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/w1280h849x4y3-4a474117.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa | Living area](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/8b3f42b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa | Private kitchen](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/69be8492.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa | Living area](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/f0d73905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TUSCAN VILLA [](https://www.expedia.ca/Houston-Hotels-TUSCAN-VILLA.h90879356.Hotel-Information) Greater Uptown 2.0/10 (3 reviews) "Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer the phone. We couldn’t stay at the property because we had no information on how to get in. We were charged full price and no refund given, I suggest you book somewhere else that has better... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James [](https://www.expedia.ca/Houston-Hotels-TUSCAN-VILLA.h90879356.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Texas-Medical-Center-Houston-Hotels.s50-n6143504-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Texas-Medical-Center-Houston-Hotels.s50-n6143504-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Texas Medical Center. ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 5353 Westheimer Rd Houston TX CA $183 CA $216 total Feb 6 - Feb 7 includes taxes & fees 8.2/10 Very Good! (3,321 reviews) [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![The Royal Sonesta Houston Galleria](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Royal Sonesta Houston Galleria 2222 West Loop South Houston TX CA $195 CA $228 total Jan 30 - Jan 31 includes taxes & fees 8.4/10 Very Good! (1,587 reviews) [](https://expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![The Westin Galleria Houston](https://images.trvl-media.com/lodging/1000000/20000/11200/11117/b45a8086_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Westin Galleria Houston 5060 W Alabama St Houston TX CA $303 CA $399 total Feb 6 - Feb 7 includes taxes & fees 9/10 Wonderful! (1,004 reviews) [](https://expedia.ca/Houston-Hotels-The-Westin-Galleria-Houston.h11117.Hotel-Information) Still don't see what you're looking for? [See all properties in Texas Medical Center.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=30%2F01%2F2026&endDate=31%2F01%2F2026®ionId=6143504&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=30%2F01%2F2026&endDate=31%2F01%2F2026®ionId=6143504&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=30%2F01%2F2026&endDate=31%2F01%2F2026®ionId=6143504&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=30%2F01%2F2026&endDate=31%2F01%2F2026®ionId=6143504&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=30%2F01%2F2026&endDate=31%2F01%2F2026®ionId=6143504&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=30%2F01%2F2026&endDate=31%2F01%2F2026®ionId=6143504&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Texas Medical Center Hotel Reviews ## Frequently asked questions ### What are the best 5-star hotels in Texas Medical Centre? ### How much does it cost to stay in a 5-star hotel in Texas Medical Centre? > - Search for the lowest price per night from CA $216 ### What makes a hotel 5 stars in Texas Medical Centre? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Greater Hobby Area ](https://www.expedia.ca/1Star-Greater-Hobby-Area-Houston-Hotels.s10-n553248635976387067-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Hockley ](https://www.expedia.ca/2Star-Hockley-Hotels.s20-0-d6355056.Travel-Guide-Filter-Hotels) - [2 Star Hotels in South Central Houston ](https://www.expedia.ca/2Star-South-Central-Houston-Houston-Hotels.s20-n553248635976476176-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Bridlewood Estates ](https://www.expedia.ca/3Star-Bridlewood-Estates-Richmond-Hotels.s30-n553248635976470240-0.Travel-Guide-Filter-Hotels) - 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