Title: 5 Stars Hotels in Texas Medical Center, Houston from CA $125 - Find Cheap Texas Medical Center Hotels With 5 Stars | Expedia.ca [Texas Medical Center Travel Guide](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Texas Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Texas-Medical-Center.d6143504.Car-Rental-Guide)[Texas Medical Center Vacations](https://expedia.ca/Texas-Medical-Center.d6143504.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Texas Medical Center, Houston from CA $125 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Texas Medical Center 5 Star Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-14&endDate=2025-10-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-15&endDate=2025-10-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Texas Medical Center 5 Star Hotels ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/d55af368.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/8367604f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Residential Suite | Private kitchenette](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/4c645ca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/60c8a315.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Post Oak Hotel at Uptown Houston The Galleria 9.6/10 Exceptional (838) "The hotel property is beautiful. " CA $728 CA $852 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Houston-Hotels-The-Post-Oak-Hotel-At-Uptown-Houston.h22340244.Hotel-Information) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/bf3873ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/42b4edb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/9821c0bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/cd32fa2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel Houston Downtown Houston 9.2/10 Wonderful (1001) "Great stay" CA $695 CA $820 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Houston-Hotels-Four-Seasons-Hotel-Houston.h20193.Hotel-Information) ![Lunch and dinner served, Chinese cuisine](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/cc0b23d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/e7547f50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/2eba3fa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/939d8a85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ACP Hotel Houston Westchase, MOD Collection by Sonesta Sharpstown 8.0/10 Very good (1010) "It's close to everything and free parking ,we enjoyed staying there " CA $106 CA $125 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/Houston-Hotels-ACP-Hotel-Westchase.h1155962.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/75cdec53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Lounge](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/60772027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/fde99bcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/506faf1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### JW Marriott Houston Downtown Downtown Houston 9.0/10 Wonderful (1006) "Clean rooms, great staff" CA $325 CA $390 total includes taxes & fees Oct 18 - Oct 19 [](https://www.expedia.ca/Houston-Hotels-JW-Marriott-Houston-Downtown.h7301257.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/31bacfbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/d5969644.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/1ff77d59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/fb9d0fa3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis Houston The Galleria 9.2/10 Wonderful (398) "Beautiful property! " CA $668 CA $797 total includes taxes & fees Oct 24 - Oct 25 [](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/4d94e615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/2fc8cb04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Modern European cuisine](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/458c38c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/89bcd23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Colombe d'Or Hotel Montrose 9.2/10 Wonderful (135) "Staff were so friendly & accommodating. Thoroughly enjoyed our stay!" CA $600 CA $702 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Houston-Hotels-La-Colombe-DOr-Hotel-Restaurant.h66954154.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/587b4f3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Private kitchen](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/2b83a530.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Living area](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/ed4d8344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/ba2f1806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 7550 Kirby Dr Braeswood Place 8.2/10 Very good (45) "I enjoyed my stay it was worth it" [](https://www.expedia.ca/Houston-Hotels-7550-Kirby-Dr.h96248257.Hotel-Information) ![Luxury Villa | Living area](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/b59486b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/9a93f3d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa | Private kitchen](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/d83b1ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/6257d303.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TUSCAN VILLA Greater Uptown 2.0/10 (3) "Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer the phone. We couldn’t stay at the property because we had no information on how to get in. We were charged full price and no refund given, I suggest you book somewhere else that has better... [](https://www.expedia.ca/Houston-Hotels-TUSCAN-VILLA.h90879356.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Texas-Medical-Center-Houston-Hotels.s50-n6143504-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Texas-Medical-Center-Houston-Hotels.s50-n6143504-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Texas Medical Center. ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Club Quarters Hotel Downtown, Houston 1085 Rusk Street, Houston, TX CA $148 CA $173 total Oct 16 - Oct 17 includes taxes & fees 8.4/10 Very Good! (3,787 reviews) [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 5353 Westheimer Rd, Houston, TX CA $171 CA $202 total Oct 30 - Oct 31 includes taxes & fees 8.2/10 Very Good! (2,649 reviews) [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![C. Baldwin, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/30000/25000/24968/dbf192ed_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### C. Baldwin, Curio Collection by Hilton 400 Dallas St, Houston, TX CA $226 CA $301 total Oct 17 - Oct 18 includes taxes & fees 8.4/10 Very Good! (1,008 reviews) [](https://expedia.ca/Houston-Hotels-C-Baldwin.h24968.Hotel-Information) Still don't see what you're looking for? [See all properties in Texas Medical Center.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6143504&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6143504&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6143504&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6143504&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6143504&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6143504&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Texas Medical Center Hotel Reviews ## Frequently asked questions ### What are the best 5-star hotels in Texas Medical Centre? > Enjoy premium amenities and refined service at [La Colombe d'Or Hotel](https://www.expedia.ca/Houston-Hotels-La-Colombe-DOr-Hotel-Restaurant.h66954154.Hotel-Information). Located around the Southwest Houston neighbourhood of Texas Medical Centre, this 5-star hotel is the leading choice for many based on reviews by our guests. ### How much does it cost to stay in a 5-star hotel in Texas Medical Centre? > The amount you pay for a 5-star hotel in Texas Medical Centre can vary according to when you decide to travel and how long you plan to be away, among a number of factors. Use our price per night filter and other search tools to land the best deal on a luxurious getaway. > > > > - Search for the lowest price per night from CA $173 ### What makes a hotel 5 stars in Texas Medical Centre? > From gourmet dining venues and 24/7 fitness centres to pools and the finest bedding, the 5-star experience in Texas Medical Centre is all about relaxation and luxury. But it calls for more than just upscale amenities to earn a 5-star rating. 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