Title: 5 Stars Hotels in Panacea, Florida  - Find Cheap Panacea Hotels With 5 Stars | Expedia.ca

[Panacea Travel Guide](https://expedia.ca/Panacea.dx3000431554)[Hotels in Panacea](https://expedia.ca/Panacea-Hotels.d3000431554.Travel-Guide-Hotels)[Vacation Rentals in Panacea](https://expedia.ca/Panacea-Vacation-Rentals.d3000431554.Travel-Guide-VacationRentals)[Flights to Panacea](https://expedia.ca/Cheap-Flights-To-Panacea.d3000431554.Travel-Guide-Flights)[Panacea Car Rentals](https://expedia.ca/Car-Rentals-In-Panacea.d3000431554.Car-Rental-Guide)[Panacea Vacation Packages](https://expedia.ca/Panacea.d3000431554.Destination-Travel-Guides)

![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# 5 Stars Hotels in Panacea, Florida 

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## Check availability on Panacea 5 Star Hotels

Tonight

[Dec 4 - Dec 5](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2025-12-04&endDate=2025-12-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 5 - Dec 6](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2025-12-05&endDate=2025-12-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2025-12-05&endDate=2025-12-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Panacea 5 Star Hotels

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## Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

[See all hotels in Panacea](https://www.expedia.ca/Hotel-Search?startDate=2025-12-18&endDate=2025-12-19&adults=2&regionId=3000431554)

![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=267&h=399&p=1&q=high)

## Top Panacea Hotel Reviews

## Find out more about Panacea

Luxury is the name of the game at the best 5 Stars hotels in Panacea. If you want to vacation like a true VIP, these are the places to go; from spacious resorts to boutique-inspired hot spots, the top Panacea 5 Stars hotels are dedicated to immersing you in the ultimate experience. Want to relax with a serene treatment at a designer spa? These properties offer them.

Interested in tasting delicious dishes from top chefs? The gourmet restaurants at the 5 Stars Panacea hotels have you covered. You’ll even find first-class hotels near the city’s must-see attractions and most upscale entertainment districts. Plus, when you book your trip with Expedia.ca, you’ll get access to fantastic rates and seasonal discounts, so you can take advantage of a cheap deal on 5 Stars hotels Panacea without giving up even an inch of quality. Everything your heart desires (and a few perks designed to make it skip a beat): That’s what’s on offer when you plan a trip to the hotels with 5 Stars in Panacea.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Panacea?

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### What makes a hotel 5 stars in Panacea?

### Are there any 5-star all-inclusive resorts in Panacea?

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