Cheap flights from Rochester to South San Diego from CA $171

View CA $171 flight on Thu, Sep. 11, 2025Opens in a new window

Popular airlines from Rochester to South San Diego

  • American Airlines

    American Airlines

  • Alaska Airlines

    Alaska Airlines

  • JetBlue Airways

    JetBlue Airways

  • Delta

    Delta

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap flights from Rochester (ROC) to South San Diego (SAN)

Prices were available within the past 7 days and start at CA $171 for one-way flights and CA $377 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Nov. 3 - Thu, Nov. 6
ROC
Rochester
SAN
San Diego
CA $377 Roundtrip, found 7 hours ago
CA $377
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Nov. 3 from Rochester to San Diego, returning Thu, Nov. 6, priced at CA $377 found 7 hours ago
American Airlines
Mon, Nov. 3 - Thu, Nov. 6
ROC
Rochester
SAN
San Diego
CA $429 Roundtrip, found 7 hours ago
CA $429
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Nov. 3 from Rochester to San Diego, returning Thu, Nov. 6, priced at CA $429 found 7 hours ago
Alaska Airlines
Mon, Nov. 3 - Thu, Nov. 6
ROC
Rochester
SAN
San Diego
CA $437 Roundtrip, found 7 hours ago
CA $437
Roundtrip
found 7 hours ago
Select Alaska Airlines flight, departing Mon, Nov. 3 from Rochester to San Diego, returning Thu, Nov. 6, priced at CA $437 found 7 hours ago
Delta
Mon, Nov. 3 - Thu, Nov. 6
ROC
Rochester
SAN
San Diego
CA $444 Roundtrip, found 7 hours ago
CA $444
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Nov. 3 from Rochester to San Diego, returning Thu, Nov. 6, priced at CA $444 found 7 hours ago
Delta
Mon, Nov. 3 - Thu, Nov. 6
ROC
Rochester
SAN
San Diego
CA $446 Roundtrip, found 7 hours ago
CA $446
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Nov. 3 from Rochester to San Diego, returning Thu, Nov. 6, priced at CA $446 found 7 hours ago
JetBlue Airways
Mon, Nov. 3 - Thu, Nov. 6
ROC
Rochester
SAN
San Diego
CA $461 Roundtrip, found 7 hours ago
CA $461
Roundtrip
found 7 hours ago
Select JetBlue Airways flight, departing Mon, Nov. 3 from Rochester to San Diego, returning Thu, Nov. 6, priced at CA $461 found 7 hours ago
*Available to Expedia members.