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CA $359 Cheap Flights from Mexico City (MEX) to Santiago (SCL)

View CA $359 flight on Thu, Dec 31, 2026Opens in a new window

Popular airlines from Benito Juarez International Airport (MEX) to Santiago Intl. Airport (SCL)

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Cheap flights from Mexico City (MEX) to Santiago (SCL)

Prices were available within the past 7 days and start at CA $359 for one-way flights and CA $727 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Thu, Dec 24 - Thu, Dec 31
MEX
Mexico City
SCL
Santiago
CA $727 Roundtrip, found 23 hours ago
CA $727
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Thu, Dec 24 from Mexico City to Santiago, returning Thu, Dec 31, priced at CA $727 found 23 hours ago
Aeromexico
Thu, Dec 24 - Thu, Dec 31
MEX
Mexico City
SCL
Santiago
CA $737 Roundtrip, found 23 hours ago
CA $737
Roundtrip
found 23 hours ago
Select Aeromexico flight, departing Thu, Dec 24 from Mexico City to Santiago, returning Thu, Dec 31, priced at CA $737 found 23 hours ago
LATAM Airlines Group
Thu, Dec 24 - Thu, Dec 31
MEX
Mexico City
SCL
Santiago
CA $795 Roundtrip, found 23 hours ago
CA $795
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Thu, Dec 24 from Mexico City to Santiago, returning Thu, Dec 31, priced at CA $795 found 23 hours ago
LATAM Airlines Group
Thu, Dec 24 - Thu, Dec 31
MEX
Mexico City
SCL
Santiago
CA $843 Roundtrip, found 23 hours ago
CA $843
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Thu, Dec 24 from Mexico City to Santiago, returning Thu, Dec 31, priced at CA $843 found 23 hours ago
Aeromexico
Fri, Jan 1 - Thu, Jan 21
MEX
Mexico City
SCL
Santiago
CA $854 Roundtrip, found 5 hours ago
CA $854
Roundtrip
found 5 hours ago
Select Aeromexico flight, departing Fri, Jan 1 from Mexico City to Santiago, returning Thu, Jan 21, priced at CA $854 found 5 hours ago
Aeromexico
Mon, Jan 18 - Mon, Feb 15
MEX
Mexico City
SCL
Santiago
CA $884 Roundtrip, found 23 hours ago
CA $884
Roundtrip
found 23 hours ago
Select Aeromexico flight, departing Mon, Jan 18 from Mexico City to Santiago, returning Mon, Feb 15, priced at CA $884 found 23 hours ago
LATAM Airlines Group
Thu, Jan 7 - Thu, Jan 28
MEX
Mexico City
SCL
Santiago
CA $897 Roundtrip, found 22 hours ago
CA $897
Roundtrip
found 22 hours ago
Select LATAM Airlines Group flight, departing Thu, Jan 7 from Mexico City to Santiago, returning Thu, Jan 28, priced at CA $897 found 22 hours ago
Copa
Fri, Jan 1 - Thu, Jan 21
MEX
Mexico City
SCL
Santiago
CA $910 Roundtrip, found 5 hours ago
CA $910
Roundtrip
found 5 hours ago
Select Copa flight, departing Fri, Jan 1 from Mexico City to Santiago, returning Thu, Jan 21, priced at CA $910 found 5 hours ago
avianca
Thu, Oct 29 - Wed, Nov 4
MEX
Mexico City
SCL
Santiago
CA $1,218 Roundtrip, found 15 hours ago
CA $1,218
Roundtrip
found 15 hours ago
Select avianca flight, departing Thu, Oct 29 from Mexico City to Santiago, returning Wed, Nov 4, priced at CA $1,218 found 15 hours ago
United
Mon, Jan 18 - Mon, Feb 15
MEX
Mexico City
SCL
Santiago
CA $1,885 Roundtrip, found 23 hours ago
CA $1,885
Roundtrip
found 23 hours ago
Select United flight, departing Mon, Jan 18 from Mexico City to Santiago, returning Mon, Feb 15, priced at CA $1,885 found 23 hours ago

Find the cheapest month to fly from Mexico City (MEX) to Santiago (SCL)

October is typically the cheapest month to fly

From CA $837 - CA $1,209 per traveller.

Frequently asked questions

How much does a flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) cost?
You can find cheap one-way flights from CA $359 and cheap return flights from CA $727 MEX to SCL with Expedia. One-way flights typically cost between CA$435 and CA$3,112, and return flights often range between CA$1,017 and CA$5,364. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when MEX to SCL ticket fares go up or down.
What is the cheapest month to fly from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The cheapest months to fly from MEX to SCL are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You have 2 airlines offering direct flights from Mexico City (MEX) to Santiago (SCL). Here are the carriers:
  • LATAM Airlines Group operates 7 direct flights from Mexico City (MEX) to Santiago (SCL) every week.
  • Aeromexico operates 7 direct flights from Mexico City (MEX) to Santiago (SCL) every week.
How do I find cheap flights from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
To find a cheap flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best airline to fly with from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) will differ from traveler to traveler. If you like to fly early, Aeromexico offers early morning flights. If price is the most important factor, LATAM Airlines Group typically offers the lowest fares. Aeromexico offers the most daily flights from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
There is 1 nonstop flight per day from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez). For even more choices, look at flights that include layovers, as there are around 69 connecting flights per day. Some common connection points include Jorge Chavez Intl. (LIM), Cancun Intl. (CUN), and George Bush Intercontinental (IAH).
What is the earliest flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The earliest flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) typically departs around 12:05 AM. This service is offered by Aeromexico and Aerolineas Argentinas. This is a seasonal service, active only in August. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You'll typically find the most flights from Mexico City International Airport (MEX) to Santiago (SCL) on a Friday, with around 35 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include Aeromexico, Copa, and Avianca. Flight options are notably more plentiful on Fridays compared to other days of the week, offering you more flexibility.
What are the most popular departure times for flights from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The most popular departure times for flights from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) are in the early morning, from 3am to 6am. Many major carriers, including Copa, Avianca and United, offer flights during this window. Many travellers prefer these times as they can arrive at their destination early in the day, giving them more time to settle in or start their activities.
How long does it take to fly from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
A nonstop flight from Mexico City (MEX) to Santiago (SCL) typically takes around 8 hours 48 minutes. This route covers a distance of approximately 6,600 kilometres. If you opt for a flight with one stop, the travel time is usually longer, averaging around 11 hours 48 minutes. Flights with two or more stops will take even longer, typically around 18 hours 30 minutes. Keep in mind that actual flight times can vary due to factors like wind patterns and air traffic, so it's always a good idea to allow for some extra time when planning your journey.
Can you fly business or first class from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Yes, you can fly business class between Mexico City (MEX) and Santiago (SCL). Airlines that offer business class service on this route include:
  • LATAM Airlines Group
  • Copa
  • Avianca
  • Aeromexico
  • United
  • Delta
  • American Airlines
How much is a business class flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
A direct, return business class ticket from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) typically costs between CA$3,594 - CA$6,215. Prices often fluctuate based on seasonality and how early you book. You may also be able to find a cheaper business class journey between Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) if you opt for a connecting flight.
How do I earn miles on a Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) flight with Expedia?
It's easy to earn miles on a Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Santiago (SCL) from Mexico City (MEX)?
If you're planning to travel to Santiago from Mexico City Intl. (MEX), you can fly directly into Arturo Merino Benitez (SCL). Some flights may connect through major hubs like George Bush Intercontinental (IAH), Jose Maria Cordova Intl. (MDE), or El Dorado Intl. (BOG) before reaching Santiago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) at the last minute?
Typically, booking a last minute flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package?
Securing a Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez)?
If you booked your Mexico City (MEX-Mexico City Intl.) to Santiago (SCL-Arturo Merino Benitez) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Mexico City Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Aerolineas Argentinas, Aeromexico, American Airlines, Copa, Delta, LATAM Airlines Group, United, avianca
Roundtrip price
CA $726
Distance
6558 km
Average flight time
8 hours 50 mins

Book with confidence

Mexico City to Santiago Flights

The easy way to book your flights from Mexico City to Santiago 

With Expedia, it’s simple to find and book flights to Santiago from Mexico City whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Arturo Merino Benitez, too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Mexico City to Santiago today, tomorrow, or this week.  

 

Save dollars with cheap flights from Mexico City Intl., MEX to Arturo Merino Benitez, SCL 

Sort your search results by price to find great deals on your flight from Mexico City to Santiago—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Santiago from Mexico City currently is just CA $727 rising to CA $1,885.  

Here are more money-saving tips: 

  • Fly in December when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Santiago  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Santiago from Mexico City 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Santiago with Expedia today.

Mexico City to Santiago Flights

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