CA $351 Cheap Flights from Guayaquil (GYE) to Santiago (SCL)

View CA $351 flight on Wed, Sep. 10, 2025Opens in a new window

Popular airlines from Jose Joaquin de Olmedo Intl. Airport (GYE) to Santiago Intl. Airport (SCL)

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Cheap flights from Guayaquil (GYE) to Santiago (SCL)

Prices were available within the past 7 days and start at CA $351 for one-way flights and CA $676 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Wed, Jan. 21 - Tue, Feb. 3
GYE
Guayaquil
SCL
Santiago
CA $676 Roundtrip, found 6 days ago
CA $676
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Jan. 21 from Guayaquil to Santiago, returning Tue, Feb. 3, priced at CA $676 found 6 days ago
LATAM Airlines Group
Thu, Jan. 22 - Tue, Feb. 3
GYE
Guayaquil
SCL
Santiago
CA $684 Roundtrip, found 6 days ago
CA $684
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, Jan. 22 from Guayaquil to Santiago, returning Tue, Feb. 3, priced at CA $684 found 6 days ago
LATAM Airlines Group
Mon, Jan. 26 - Fri, Feb. 13
GYE
Guayaquil
SCL
Santiago
CA $692 Roundtrip, found 6 days ago
CA $692
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Mon, Jan. 26 from Guayaquil to Santiago, returning Fri, Feb. 13, priced at CA $692 found 6 days ago
Copa
Mon, Jan. 5 - Wed, Jan. 21
GYE
Guayaquil
SCL
Santiago
CA $696 Roundtrip, found 6 days ago
CA $696
Roundtrip
found 6 days ago
Select Copa flight, departing Mon, Jan. 5 from Guayaquil to Santiago, returning Wed, Jan. 21, priced at CA $696 found 6 days ago
LATAM Airlines Group
Sat, Jan. 17 - Thu, Jan. 29
GYE
Guayaquil
SCL
Santiago
CA $703 Roundtrip, found 6 days ago
CA $703
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, Jan. 17 from Guayaquil to Santiago, returning Thu, Jan. 29, priced at CA $703 found 6 days ago
LATAM Airlines Group
Wed, Jan. 14 - Thu, Jan. 29
GYE
Guayaquil
SCL
Santiago
CA $711 Roundtrip, found 6 days ago
CA $711
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Jan. 14 from Guayaquil to Santiago, returning Thu, Jan. 29, priced at CA $711 found 6 days ago
LATAM Airlines Group
Wed, Dec. 24 - Wed, Dec. 31
GYE
Guayaquil
SCL
Santiago
CA $719 Roundtrip, found 6 days ago
CA $719
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Dec. 24 from Guayaquil to Santiago, returning Wed, Dec. 31, priced at CA $719 found 6 days ago
LATAM Airlines Group
Wed, Dec. 24 - Tue, Dec. 30
GYE
Guayaquil
SCL
Santiago
CA $727 Roundtrip, found 6 days ago
CA $727
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Dec. 24 from Guayaquil to Santiago, returning Tue, Dec. 30, priced at CA $727 found 6 days ago
Copa
Thu, Dec. 25 - Wed, Dec. 31
GYE
Guayaquil
SCL
Santiago
CA $730 Roundtrip, found 6 days ago
CA $730
Roundtrip
found 6 days ago
Select Copa flight, departing Thu, Dec. 25 from Guayaquil to Santiago, returning Wed, Dec. 31, priced at CA $730 found 6 days ago
LATAM Airlines Group
Tue, Dec. 23 - Tue, Dec. 30
GYE
Guayaquil
SCL
Santiago
CA $735 Roundtrip, found 6 days ago
CA $735
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Tue, Dec. 23 from Guayaquil to Santiago, returning Tue, Dec. 30, priced at CA $735 found 6 days ago

Find the cheapest month to fly from Guayaquil (GYE) to Santiago (SCL)

March is typically the cheapest month to fly

From CA $445 - CA $769 per traveller.

Graph displaying average flight prices per month

Flight from Guayaquil to Santiago (GYE - SCL) route information
Origin airport
Jose Joaquin de Olmedo Intl.
Destination airport
Arturo Merino Benitez
Roundtrip price
CA $675
Distance
3580 km
Average flight time
3 hours 53 mins

Guayaquil to Santiago Flights

The easy way to book your flights from Guayaquil to Santiago 

With Expedia, it’s simple to find and book flights to Santiago from Guayaquil whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are LATAM Airlines nonstop flights to Arturo Merino Benitez, too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Guayaquil to Santiago today, tomorrow, or this week.  

 

Save dollars with cheap flights from Jose Joaquin de Olmedo Intl., GYE to Arturo Merino Benitez, SCL 

Sort your search results by price to find great deals on your flight from Guayaquil to Santiago—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Santiago from Guayaquil currently is just CA $676 rising to CA $735.  

Here are more money-saving tips: 

  • Fly in January when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Santiago  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Santiago from Guayaquil 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Santiago with Expedia today.

Frequently asked questions

How much is a flight from GYE to Santiago International Airport?
Round-trip flights between Jose Joaquin de Olmedo Intl. Airport (GYE) and Arturo Merino Benitez Airport (SCL) start from CA $676. This figure is based on fares available within the last 7 days on Expedia for flights departing within the next year — make your booking ASAP so you don't miss out. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Airport of Guayaquil to SCL?
Most flights can be cancelled online, but each air carrier has its own terms and conditions. If you do decide to cancel your flight, visit our Customer Service Portal and follow the instructions.
How do I find cheap flights from GYE to Arturo Merino Benitez Airport (SCL) that have flexible change policies?
Use our "No change fees" filter to find flexible travel options for your flight from GYE to SCL. This allows you to lock in a low rate ahead of time and still have the freedom to reschedule without any extra fees. If the new flight costs more, you'll just cover the difference.
How many hours is the flight from GYE to SCL?
Averaging 10 hours and 56 minutes, the flight from GYE to SCL is a long one. To make your journey more pleasant, remember to pack a neck pillow and some noise-cancelling headphones.
How far is the flight from GYE to Arturo Merino Benitez Airport (SCL)?
The flying distance between Jose Joaquin de Olmedo Intl. Airport (GYE) (GYE) and SCL (SCL) is 3,600 kilometres. Sneak in a nap or make a start on the latest bestseller and the trip will zip on by.
Which airlines fly direct from Jose Joaquin de Olmedo Intl. Airport (GYE) to Santiago International Airport?
If you're eager to fly straight from GYE to SCL, LATAM Airlines (LA) is a popular option. It operates 30 monthly flights between Guayas and Santiago.
Are Airport of Guayaquil to SCL flight tickets cheaper when they're purchased at the last minute?
Last-minute planners can occasionally score a bargain, with some of the cheapest fares from GYE to Santiago International Airport cropping up a few weeks before the departure date. If you'd rather plan ahead, Expedia compares and updates the best flight deals continuously — as early as a year in advance in some cases. It depends on the carrier though, as not all airlines publish prices that far in advance.

Explore a world of travel with Expedia

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